A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea

scholarly article

A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2008PNAS..10511346C
P356DOI10.1073/PNAS.0803622105
P932PMC publication ID2516264
P698PubMed publication ID18685110
P5875ResearchGate publication ID23154053

P2093author name stringAmy M Lum
Camilla M Kao
Jonathan A Vroom
Chinping Chng
P2860cites workA rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
The BldD protein from Streptomyces coelicolor is a DNA-binding proteinQ29347205
A connection between stress and development in the multicellular prokaryote Streptomyces coelicolor A3(2).Q29347209
BldD is a direct regulator of key developmental genes in Streptomyces coelicolor A3(2).Q29347210
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)Q29547307
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosminQ30764407
Induction of ppGpp synthesis in Streptomyces coelicolor A3(2) grown under conditions of nutritional sufficiency elicits actII-ORF4 transcription and actinorhodin biosynthesis.Q31727492
The bldD gene of Streptomyces coelicolor A3(2): a regulatory gene involved in morphogenesis and antibiotic production.Q32084472
Identification of the DNA bases of a DNase I footprint by the use of dye primer sequencing on an automated capillary DNA analysis instrumentQ36537407
Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin productionQ37294579
The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of StreptomycesQ38333791
Transcriptional organization of the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea.Q39498033
Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2).Q39943613
A Morphological and Genetic Mapping Study of Bald Colony Mutants of Streptomyces coelicolorQ40027725
Production of the potent antibacterial polyketide erythromycin C in Escherichia coliQ40425373
In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis.Q40584907
Engineering antibiotic producers to overcome the limitations of classical strain improvement programsQ41300727
Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.Q42044034
A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony developmentQ42649518
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreumQ44981597
Precursor-directed production of erythromycin analogs by Saccharopolyspora erythraeaQ46192855
Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolorQ46704762
A binding site for activation by the Bacillus subtilis AhrC protein, a repressor/activator of arginine metabolismQ48071335
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.Q48080782
Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays.Q51646348
Crystal structure of the DNA-binding domain of BldD, a central regulator of aerial mycelium formation in Streptomyces coelicolor A3(2).Q52570784
The mRNA for the 23S rRNA methylase encoded by the ermE gene of Saccharopolyspora erythraea is translated in the absence of a conventional ribosome-binding site.Q54192770
BldD from Streptomyces coelicolor is a non-essential global regulator that binds its own promoter as a dimerQ73755489
P4510describes a project that usesImageQuantQ112270642
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectantibioticQ12187
Saccharopolyspora erythraeaQ7396613
erythromycinQ213511
P1104number of pages6
P304page(s)11346-11351
P577publication date2008-08-06
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea
P478volume105

Reverse relations

cites work (P2860)
Q40315120A MarR Family Transcriptional Regulator, DptR3, Activates Daptomycin Biosynthesis and Morphological Differentiation in Streptomyces roseosporus
Q45162574Actinoplanes Swims into the Molecular Age.
Q38152725Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements
Q36970549Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes
Q26784492Antibacterial Discovery and Development: From Gene to Product and Back
Q37256192Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes
Q42225525CRP represses the CRISPR/Cas system in Escherichia coli: evidence that endogenous CRISPR spacers impede phage P1 replication.
Q50610314Capturing the target genes of BldD in Saccharopolyspora erythraea using improved genomic SELEX method.
Q37776153Carbon source regulation of antibiotic production
Q90260164Characterization and engineering of the Lrp/AsnC family regulator SACE_5717 for erythromycin overproduction in Saccharopolyspora erythraea
Q35984452Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain
Q26799100Cyclic Dinucleotide-Controlled Regulatory Pathways in Streptomyces Species
Q51809980DasR is a pleiotropic regulator required for antibiotic production, pigment biosynthesis, and morphological development in Saccharopolyspora erythraea.
Q34629213Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences
Q37606863Differential proteomic profiling reveals regulatory proteins and novel links between primary metabolism and spinosad production in Saccharopolyspora spinosa
Q34643562Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea
Q64984704Dissolution of the Disparate: Co-ordinate Regulation in Antibiotic Biosynthesis.
Q38585753Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes
Q83638594Heterologous production of polyketides in bacteria
Q51865691Identification of SACE_7040, a member of TetR family related to the morphological differentiation of Saccharopolyspora erythraea.
Q33658608Identifying modules of coexpressed transcript units and their organization of Saccharopolyspora erythraea from time series gene expression profiles
Q43213050Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea.
Q35272446Negative effect of glucose on ompA mRNA stability: a potential role of cyclic AMP in the repression of hfq in Escherichia coli
Q47993512Novel and tightly regulated resorcinol and cumate-inducible expression systems for Streptomyces and other actinobacteria
Q37154618Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production
Q84242823Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators
Q40329481Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor
Q91790596Regulation of Bottromycin Biosynthesis Involves an Internal Transcriptional Start Site and a Cluster-Situated Modulator
Q44391826Regulation of Sporangium Formation by BldD in the Rare Actinomycete Actinoplanes missouriensis
Q49851792Regulation of specialised metabolites in Actinobacteria - Expanding the paradigms.
Q34192714Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in Streptomyces ambofaciens
Q37300780SACE_0012, a TetR-family transcriptional regulator, affects the morphogenesis of Saccharopolyspora erythraea
Q53560236SACE_3986, a TetR family transcriptional regulator, negatively controls erythromycin biosynthesis in Saccharopolyspora erythraea.
Q37426455SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.
Q92761494Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes
Q58758125Signaling specificity in the c-di-GMP-dependent network regulating antibiotic synthesis in Lysobacter
Q27015037Signals and regulators that govern Streptomyces development
Q44110767Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess
Q34883444Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains
Q47861123TetR Family Transcriptional Regulator PccD Negatively Controls Propionyl Coenzyme A Assimilation in Saccharopolyspora erythraea.
Q34121159Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Q38616129c-di-GMP signalling and the regulation of developmental transitions in streptomycetes.

Search more.