Molecular chaperones regulate p53 and suppress senescence programs.

scientific article published on 25 May 2007

Molecular chaperones regulate p53 and suppress senescence programs. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.FEBSLET.2007.05.036
P932PMC publication ID3433766
P698PubMed publication ID17555746
P5875ResearchGate publication ID6280643

P50authorVladimir L. GabaiQ54877934
P2093author name stringJulia Yaglom
Michael Y Sherman
Cornelia O'Callaghan
P2860cites workSpecific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell lineQ70074091
Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugsQ73002431
Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblastsQ73349019
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agentsQ78125095
High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathwaysQ79856384
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisQ24681977
c-MYC: more than just a matter of life and deathQ28205057
Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 proteinQ28207814
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationQ29617915
Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75.Q31048734
Mechanisms of apoptosis by c-MycQ33667315
Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo.Q33736465
Action of Myc in vivo - proliferation and apoptosisQ33840451
Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agentQ33897870
Replicative senescence as a barrier to human cancerQ33921353
AnoikisQ33978500
Role of the heat shock response and molecular chaperones in oncogenesis and cell deathQ34052682
Four deaths and a funeral: from caspases to alternative mechanisms.Q34325335
Heat shock proteins in cancer: chaperones of tumorigenesisQ34495261
Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblastsQ34552889
Invited review: Interplay between molecular chaperones and signaling pathways in survival of heat shockQ34564831
Tumor cell senescence in cancer treatmentQ35143435
Senescence of human fibroblasts induced by oncogenic Raf.Q35210205
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseasesQ35680797
The normal response to RAS: senescence or transformation?Q35778503
"The stress of dying": the role of heat shock proteins in the regulation of apoptosisQ35787941
A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinomaQ35809875
Intrinsic tumour suppressionQ35953133
Ink4a/Arf links senescence and agingQ35974880
The signals and pathways activating cellular senescenceQ36060167
Endothelial agingQ36093530
Telomere and telomerase dynamics in human cellsQ36172564
Mesenchymal stem cell agingQ36242270
p16INK4a as a second effector of the telomere damage pathwayQ36264069
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathwaysQ36274956
Senescence of hematopoietic stem cells and bone marrow failureQ36278284
Proliferative senescence in hematopoietic stem cells during ex-vivo expansionQ36355574
Premature senescence of endothelial cells: Methusaleh's dilemmaQ36444277
Stop and go: anti-proliferative and mitogenic functions of the transcription factor C/EBPbetaQ36474712
Telomeres: cancer to human agingQ36528826
p53-Dependent and -independent functions of the Arf tumor suppressorQ36547718
DeltaNp63alpha up-regulates the Hsp70 gene in human cancerQ38330737
Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sitesQ38350716
Apoptosis mediated by p53 in rat neural AF5 cells following treatment with hydrogen peroxide and staurosporineQ40245002
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.Q40370477
Differential oncogenic Ras signaling and senescence in tumor cellsQ40502532
Activation of ATM and phosphorylation of p53 by heat shockQ40750164
The role of bcl-2 expression in breast carcinomas (Review).Q40849081
Genetic differences between the pancytosolic and perinuclear forms of murine mortalin.Q41179798
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanismsQ41197754
NIH 3T3 cells malignantly transformed by mot-2 show inactivation and cytoplasmic sequestration of the p53 proteinQ42806765
Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.Q42825164
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.Q42832610
RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysisQ44681202
Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversionQ46230264
Molecular chaperones and the stress of oncogenesisQ47785215
Demonstration of selective protein complexes of p53 with 73 kDa heat shock cognate protein, but not with 72 kDa heat shock protein in human tumor cells.Q53478145
Molecular signature of oncogenic ras-induced senescence.Q53632631
Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth.Q53851410
Escape from premature senescence is not sufficient for oncogenic transformation by Ras.Q54021692
Executing Cell SenescenceQ57580197
Executing cell senescenceQ57580253
Hsp70-2 is required for tumor cell growth and survivalQ59487815
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectmolecular chaperonesQ422496
P304page(s)3711-3715
P577publication date2007-05-25
P1433published inFEBS LettersQ1388051
P1476titleMolecular chaperones regulate p53 and suppress senescence programs
P478volume581

Reverse relations

cites work (P2860)
Q42552152Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents
Q39227263Biological features of core networks that result from a high-fat diet in hepatic and pulmonary tissues in mammary tumour-bearing, obesity-resistant mice
Q43061452Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability
Q33972062Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostaining
Q42494627E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts
Q33956906Heat shock protein 70 (hsp70) as an emerging drug target.
Q37033622Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells.
Q35070272Heat shock proteins in breast cancer progression--a suitable case for treatment?
Q37329764Hsps and aging
Q49012326Ischaemia-induced protein ubiquitinylation is differentially accompanied with heat-shock protein 70 expression after naïve and preconditioned ischaemia
Q33700800Prognostic implication of HSPA (HSP70) in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy.
Q34632255The complexities of p97 function in health and disease

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