Structural basis of cohesin cleavage by separase

scientific article published on 30 March 2016

Structural basis of cohesin cleavage by separase is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1042435064
P356DOI10.1038/NATURE17402
P932PMC publication ID4847710
P698PubMed publication ID27027290
P5875ResearchGate publication ID299498630

P2093author name stringHongtao Yu
Xuelian Luo
Zhonghui Lin
P2860cites workDissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.Q21146371
Structural basis of caspase-7 inhibition by XIAPQ24290942
Cohesin cleavage by separase required for anaphase and cytokinesis in human cellsQ24291574
Regulation of human separase by securin binding and autocleavageQ24305210
Shugoshin collaborates with protein phosphatase 2A to protect cohesinQ24307927
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregationQ24312909
MolProbity: all-atom structure validation for macromolecular crystallographyQ24649111
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent mannerQ24655049
Dimer formation drives the activation of the cell death protease caspase 9Q27636617
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutesQ27860502
Coot: model-building tools for molecular graphicsQ27860505
Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycinQ27860688
Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeastQ27934390
Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19Q27936335
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.Q27937127
An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeastQ27938525
Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesisQ28140028
Closing the cohesin ring: structure and function of its Smc3-kleisin interfaceQ28251894
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerizationQ28275527
Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeastQ33948005
JLigand: a graphical tool for the CCP4 template-restraint libraryQ34233185
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosisQ34317805
Caspase activation: revisiting the induced proximity modelQ34328287
Mutual inhibition of separase and Cdk1 by two-step complex formationQ34430229
Overexpression of Separase induces aneuploidy and mammary tumorigenesisQ36861774
Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosisQ41375954
Characterization of a DNA exit gate in the human cohesin ring.Q42694247
Dual inhibition of sister chromatid separation at metaphaseQ48873086
The dual mechanism of separase regulation by securinQ52161908
Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.Q52947646
Kendrin is a novel substrate for separase involved in the licensing of centriole duplication.Q53171887
Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase.Q53636254
Domain structure of separase and its binding to securin as determined by EM.Q55040860
Studies on Substrate Recognition by the Budding Yeast SeparaseQ60338806
Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separaseQ84039111
P433issue7597
P407language of work or nameEnglishQ1860
P304page(s)131-134
P577publication date2016-03-30
P1433published inNatureQ180445
P1476titleStructural basis of cohesin cleavage by separase
P478volume532

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cites work (P2860)
Q50060450A primer on caspase mechanisms
Q39126022Biology and insights into the role of cohesin protease separase in human malignancies
Q52757935Centromeric Cohesin: Molecular Glue and Much More.
Q91291816Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
Q52716163Conservation of the separase regulatory domain.
Q41598780Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.
Q39163590Cutting in the middleman: hidden substrates at the interface between proteases and plant development
Q43029071Interaction network of the ribosome assembly machinery from a eukaryotic thermophile.
Q48155911Molecular Genetic Analysis of Human Endometrial Mesenchymal Stem Cells That Survived Sublethal Heat Shock.
Q42322424Molecular mechanism for the regulation of yeast separase by securin
Q92034270Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase
Q33810216Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
Q48217215Protease dead separase inhibits chromosome segregation and RAB-11 vesicle trafficking
Q39145080Releasing the cohesin ring: A rigid scaffold model for opening the DNA exit gate by Pds5 and Wapl
Q93163992Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2
Q48311597Separase-securin complex: a cunning way to control chromosome segregation
Q93163984Separase-triggered apoptosis enforces minimal length of mitosis
Q39038164Separase: Function Beyond Cohesion Cleavage and an Emerging Oncogene
Q52372499Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis.
Q49918054Structural biology of the separase-securin complex with crucial roles in chromosome segregation.
Q55315131Suppressor mutation analysis combined with 3D modeling explains cohesin's capacity to hold and release DNA.
Q55015741The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes.

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