The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network

scientific article published on 28 April 2016

The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1040977830
P356DOI10.1038/SREP25108
P932PMC publication ID4848494
P698PubMed publication ID27121375

P50authorJordan A BeardQ59691696
Justin HillsQ57902125
P2093author name stringTaosheng Chen
Yong-Dong Wang
Milu T Cherian
Alexa Tenga
Jessica D Hoyer
P2860cites workHuman MicroRNA targetsQ21563637
p53 mediates the negative regulation of MDM2 by orphan receptor TR3Q24321873
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activationQ24530187
The NR4A subgroup: immediate early response genes with pleiotropic physiological rolesQ24540372
PUMA mediates the apoptotic response to p53 in colorectal cancer cellsQ24550772
MicroRNAs: target recognition and regulatory functionsQ24609584
miR-34a repression of SIRT1 regulates apoptosisQ24652720
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53Q24657532
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
DNA hypermethylation of microRNA-34b/c has prognostic value for stage Ⅰ non-small cell lung cancerQ83557235
MicroRNA-34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1Q85240544
Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells.Q39584006
Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancerQ39592978
Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cellsQ39633529
Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancerQ39775794
NGFI-B nuclear orphan receptor Nurr1 interacts with p53 and suppresses its transcriptional activity.Q39813907
A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor geneQ39978280
Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancerQ40350277
Intact p53-dependent responses in miR-34-deficient mice.Q42251432
Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosisQ46727309
Reduced levels of miR-34a in neuroblastoma are not caused by mutations in the TP53 binding site.Q47992879
Nuclear orphan receptor NR4A2 confers chemoresistance and predicts unfavorable prognosis of colorectal carcinoma patients who received postoperative chemotherapy.Q50870764
miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer.Q53306726
Combinatorial microRNA target predictionsQ27860510
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
The miR-34 family in cancer and apoptosisQ28245865
p21 is necessary for the p53-mediated G1 arrest in human cancer cellsQ28291118
Principles for modulation of the nuclear receptor superfamilyQ28291197
Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancerQ28291502
A microRNA component of the p53 tumour suppressor networkQ28305330
In-depth analysis shows synergy between erlotinib and miR-34aQ28539851
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
Transcriptional activation of miR-34a contributes to p53-mediated apoptosisQ29619556
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cellsQ33386807
Frequent downregulation of miR-34 family in human ovarian cancersQ33658229
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiationQ33825730
Identification of microRNA-regulated gene networks by expression analysis of target genesQ34255426
Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancerQ34630752
miR-34 - a microRNA replacement therapy is headed to the clinicQ34640230
The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancerQ34771536
Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elementsQ34865226
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repairQ35393272
MiR-34b is associated with clinical outcome in triple-negative breast cancer patientsQ35950656
MicroRNA-132 promotes estradiol synthesis in ovarian granulosa cells via translational repression of Nurr1.Q35964665
The predictive effect of overexpressed miR-34a on good survival of cancer patients: a systematic review and meta-analysisQ36111707
NuMA is required for the selective induction of p53 target genesQ36978256
1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growthQ37104035
Nuclear receptor drug discoveryQ37229006
miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cellsQ37581142
A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.Q37631219
Targeting of mRNAs by multiple miRNAs: the next stepQ37700158
Therapeutic targeting of microRNAs: current status and future challengesQ38228101
Mir-34: a new weapon against cancer?Q38253374
Expression of orphan nuclear receptor NR4A2 in gastric cancer cells confers chemoresistance and predicts an unfavorable postoperative survival of gastric cancer patients with chemotherapy.Q39131387
miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expressionQ39397509
miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancyQ39465507
PGE₂ targets squamous cell carcinoma cell with the activated epidermal growth factor receptor family for survival against 5-fluorouracil through NR4A2 inductionQ39542863
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
P304page(s)25108
P577publication date2016-04-28
P1433published inScientific ReportsQ2261792
P1476titleThe orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network
P478volume6

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cites work (P2860)
Q41774349Activated Notch signaling augments cell growth in hepatocellular carcinoma via up-regulating the nuclear receptor NR4A2.
Q89859882Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer's Disease
Q92189114Joint Transcriptomic Analysis of Lung Cancer and Other Lung Diseases
Q46150904Long 3'UTR of Nurr1 mRNAs is targeted by miRNAs in mesencephalic dopamine neurons
Q47329715MicroRNA-137 promotes endothelial progenitor cell proliferation and angiogenesis in cerebral ischemic stroke mice by targeting NR4A2 through the Notch pathway.
Q61800287MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer
Q93222983Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis
Q39015118Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis
Q64259767Roles of MicroRNA-34a in Epithelial to Mesenchymal Transition, Competing Endogenous RNA Sponging and Its Therapeutic Potential
Q47148529miR-145-5p/Nurr1/TNF-α Signaling-Induced Microglia Activation Regulates Neuron Injury of Acute Cerebral Ischemic/Reperfusion in Rats
Q47660322miR-34a Regulates Expression of the Stathmin-1 Oncoprotein and Prostate Cancer Progression

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