The spliceosome: a ribozyme at heart?

scientific article published on July 2007

The spliceosome: a ribozyme at heart? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1515/BC.2007.080
P698PubMed publication ID17570821

P2093author name stringSaba Valadkhan
P2860cites workMore than one way to splice an RNA: branching without a bulge and splicing without branching in group II introns.Q43206306
Splicing-related catalysis by protein-free snRNAsQ43770734
Ribozyme catalysis from the major groove of group II intron domain 5.Q47858571
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junctionQ57080150
Metal ion catalysis during splicing of premessenger RNAQ58324056
Prp8 protein: at the heart of the spliceosomeQ24537373
Metal binding and base ionization in the U6 RNA intramolecular stem-loop structureQ27638935
Group II introns: structure and catalytic versatility of large natural ribozymesQ28188097
Towards understanding the catalytic core structure of the spliceosomeQ28252801
A single active-site region for a group II intronQ28258438
Allosteric cascade of spliceosome activationQ29615086
Roles of protein subunits in RNA-protein complexes: lessons from ribonuclease P.Q33339521
A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeastQ34362402
Characterization of the catalytic activity of U2 and U6 snRNAsQ34365232
Ribozyme speed limitsQ35180337
snRNAs as the catalysts of pre-mRNA splicingQ36293890
Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosomeQ36723537
Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysisQ38296517
A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicingQ41354468
Multiple functions for the invariant AGC triad of U6 snRNA.Q41815683
Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomesQ42410354
Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.Q42679830
A role for U2/U6 helix Ib in 5' splice site selectionQ43206273
P433issue7
P921main subjectribozymeQ205858
spliceosomeQ915868
P304page(s)693-697
P577publication date2007-07-01
P1433published inBiological ChemistryQ4914948
P1476titleThe spliceosome: a ribozyme at heart?
P478volume388

Reverse relations

cites work (P2860)
Q53778542A PORR domain protein required for rpl2 and ccmF(C) intron splicing and for the biogenesis of c-type cytochromes in Arabidopsis mitochondria.
Q39029178A role for H/ACA and C/D small nucleolar RNAs in viral replication
Q37097405Analysis of RNA folding and ribonucleoprotein assembly by single-molecule fluorescence spectroscopy.
Q38335658Entropy and Mg2+ control ligand affinity and specificity in the malachite green binding RNA aptamer
Q33533635Evolution of spliceosomal introns following endosymbiotic gene transfer
Q27654589Identification of an Imino Group Indispensable for Cleavage by a Small Ribozyme
Q34372484Isolation and characterization of functional tripartite group II introns using a Tn5-based genetic screen
Q39783741Limited complementarity between U1 snRNA and a retroviral 5' splice site permits its attenuation via RNA secondary structure
Q41834871Metal binding and substrate positioning by evolutionarily invariant U6 sequences in catalytically active protein-free snRNAs
Q37455511Model systems: how chemical biologists study RNA.
Q28754532Primitive templated catalysis of a peptide ligation by self-folding RNAs
Q34018172Protein-free small nuclear RNAs catalyze a two-step splicing reaction
Q36955546RNA processing control in avian retroviruses
Q38119542Role of small nuclear RNAs in eukaryotic gene expression
Q37324172Single-Molecule Fluorescence Studies of RNA: A Decade's Progress
Q37372096Single-molecule fluorescence methods for the analysis of RNA folding and ribonucleoprotein assembly
Q29994423Sm/Lsm genes provide a glimpse into the early evolution of the spliceosome
Q37187968Spliceosomal immunophilins
Q39174878Splicing of an intervening sequence by protein-free human snRNAs
Q37460883Splicing of mRNA precursors: the role of RNAs and proteins in catalysis
Q35567471Structure and stability of RNA/RNA kissing complex: with application to HIV dimerization initiation signal
Q37809832The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine
Q43214653The use of simple model systems to study spliceosomal catalysis
Q42210927Trans-splicing versatility of the Ll.LtrB group II intron
Q38115287U6 RNA biogenesis and disease association
Q54361107Understanding catalysis of phosphate-transfer reactions by the large ribozymes.
Q27650449X-ray Structures of U2 snRNA−Branchpoint Duplexes Containing Conserved Pseudouridines † ‡

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