Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC.

scientific article published on March 1992

Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1992PNAS...89.1616P
P356DOI10.1073/PNAS.89.5.1616
P932PMC publication ID48503
P698PubMed publication ID1542652
P5875ResearchGate publication ID21612378

P2093author name stringFusco A
Santoro M
Bongarzone I
Grieco M
Pierotti MA
Jenkins RB
Herrmann MA
Sozzi G
Miozzo M
Monzini N
P2860cites workDevelopmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming geneQ24298289
Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicingQ24339506
cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell lineQ28117244
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequencesQ28282360
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell deathQ29620000
Analysis by pulsed field gel electrophoresis reveals complex rearrangements in two MET alleles in a chemically-treated human cell line, MNNG-HOS.Q34234846
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomasQ34372878
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocationQ34559025
Differential expression of the normal and of the translocated human c-myc oncogenes in B cellsQ37344941
Suppressors of the malignant phenotypeQ37833593
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastasesQ42807477
Molecular cloning of a new transforming gene from a chemically transformed human cell line.Q45345810
Megabase inversions in the human genome as physiological eventsQ48254994
The oncogene associated with human papillary thyroid carcinoma (PTC) is assigned to chromosome 10 q11-q12 in the same region as multiple endocrine neoplasia type 2A (MEN2A).Q52246921
Fused transcript of abl and bcr genes in chronic myelogenous leukaemiaQ59064021
Oncogenicity of the ret transforming gene in MMTV/ret transgenic miceQ67656982
Frequent occurrence of cytogenetic abnormalities in sporadic nonmedullary thyroid carcinomaQ68920794
High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinomaQ69398273
Human ret proto-oncogene mapped to chromosome 10q11.2.Q69558463
Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTCQ70111753
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1616-1620
P577publication date1992-03-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleCharacterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC.
P478volume89

Reverse relations

cites work (P2860)
Q35746558'Chromosomal Rainbows' Detect Oncogenic Rearrangements of Signaling Molecules in Thyroid Tumors
Q3694978020 years of RET/PTC in thyroid cancer: clinico-pathological correlations
Q62397584A PDGFRB-positive acute myeloid malignancy with a new t(5;12)(q33;p13.3) involving the ERC1 gene
Q34013654A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells
Q37686882A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival
Q42800418A t(10;17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma
Q40849447Accumulation of allelic losses on chromosome 10 in human gliomas at recurrence
Q72684603Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident
Q33813441Advances in cancer cytogenetics
Q45829274Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC.
Q47833329Assessment of molecular testing in fine-needle aspiration biopsy samples: an experience in a Chinese population
Q34550400BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer
Q33950311Balanced translocation (3;7)(p25;q34): another mechanism of tumorigenesis in follicular thyroid carcinoma?
Q39700806CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1.
Q47634740CCDC6: the identity of a protein known to be partner in fusion.
Q42497065Case report: a p.C618S RET proto-oncogene germline mutation in a large Chinese pedigree with familial medullary thyroid carcinoma
Q34085418Case-Control Genome-Wide Association Study of Attention-Deficit/Hyperactivity Disorder
Q34711521Chromosomal rearrangements in post-Chernobyl papillary thyroid carcinomas: evaluation by spectral karyotyping and automated interphase FISH
Q34214053Chromosomal rearrangements in thyroid carcinomas: a recombination or death dilemma
Q52512616Chromosomal translocations in human cancer.
Q37800593Cytogenetic and molecular events in adenoma and well-differentiated thyroid follicular-cell neoplasia
Q58813561Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas
Q72046520Cytogenetic findings in 31 papillary thyroid carcinomas
Q37212268DNA probe pooling for rapid delineation of chromosomal breakpoints
Q42281387Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridisation
Q35833808Detection of RET proto-oncogene point mutations in paraffin-embedded pheochromocytoma specimens by nonradioactive single-strand conformation polymorphism analysis and direct sequencing
Q40819992Diagnostic and prognostic markers in differentiated thyroid cancer
Q34721796Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues
Q34359802Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis
Q43572298Expression of the RET proto-oncogene in papillary thyroid carcinoma and its correlation with clinical outcome
Q57382361FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations
Q43599672Gene rearrangements in radiation-induced thyroid carcinogenesis
Q34288667H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization.
Q43752781High prevalence of RET tyrosine kinase activation in Mexican patients with papillary thyroid carcinomas
Q34194261How familial cancer genes and environmentally induced oncogenes have changed the endocrine landscape
Q34474368Identification of sumoylation sites in CCDC6, the first identified RET partner gene in papillary thyroid carcinoma, uncovers a mode of regulating CCDC6 function on CREB1 transcriptional activity
Q33691784Influence of RET/PTC1 and RET/PTC3 oncoproteins in radiation-induced papillary thyroid carcinomas on amounts of cytoskeletal protein species
Q35977327Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma
Q34617571Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage.
Q35976585Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours
Q67482944Keeping track of the translocations
Q34550445Kinase expression and chromosomal rearrangements in papillary thyroid cancer tissues: investigations at the molecular and microscopic levels
Q42828135Loss of function effect of RET mutations causing Hirschsprung disease.
Q54781483Loss of heterozygosity mutations of tumor suppressor genes in cytologically atypical areas in chronic lymphocytic thyroiditis.
Q34662980Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma.
Q24611227Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A
Q38466453Molecular cytogenetic characterization of chromosome 9-derived material in a human thyroid cancer cell line
Q37924088Molecular genetics and diagnosis of thyroid cancer
Q35208510Molecular pathogenesis of thyroid cancer
Q42798821New breakpoints in both the H4 and RET genes create a variant of PTC-1 in a post-Chernobyl papillary thyroid carcinoma
Q36361115New treatment in advanced thyroid cancer
Q40698212Oncogenes and anti-oncogenes in human epithelial thyroid tumors
Q27824825Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
Q36135918RET activation in adult and childhood papillary thyroid carcinoma using a reverse transcriptase-n-polymerase chain reaction approach on archival-nested material
Q74235643RET rearrangements in familial papillary thyroid carcinomas
Q54250039RET/PTC activation in human thyroid carcinomas
Q33599429RET/PTC and CK19 expression in papillary thyroid carcinoma and its clinicopathologic correlation
Q28214459RET/PTC rearrangement in thyroid tumors
Q70588382Regional assignment of the gene coding for a human Graves' disease autoantigen to 10q21.3-q22.1.
Q41019851Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.
Q41878891Rethinking the role of oncogenes in papillary thyroid cancer initiation
Q24533621Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.
Q28776010Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B
Q55023816Somatic mutations in RET exons 12 and 15 in sporadic medullary thyroid carcinomas: different spectrum of mutations in sporadic type from hereditary type.
Q45130742TIMP1 and SERPIN-A overexpression and TFF3 and CRABP1 underexpression as biomarkers for papillary thyroid carcinoma.
Q79894991TPM3/PDGFRB fusion transcript and its reciprocal in chronic eosinophilic leukemia
Q24311495The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain
Q34735847The Pathology of Medullary Carcinoma of the Thyroid: Review of the Literature and Personal Experience on 62 Cases
Q41350370The RET proto-oncogene: a challenge to our understanding of disease pathogenesis
Q38496502The emerging complexity of gene fusions in cancer
Q36760027The impact of translocations and gene fusions on cancer causation
Q58453418The management of thyroid nodules and cancer in the molecular era
Q47920723The molecular genetics of endocrine tumours
Q38004366The pituitary tumor transforming gene in thyroid cancer
Q36455074The role of immunohistochemical markers in the diagnosis of follicular-patterned lesions of the thyroid
Q40931125The role of the immune system in anti-tumour responses. Potential for drug therapy
Q34293074The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2.
Q38135137Translational research in endocrine surgery
Q37363960Translocations in epithelial cancers
Q38020834Vandetanib for the treatment of metastatic medullary thyroid cancer
Q46211426XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway.

Search more.