Bioimaging real-time PXR-dependent mdr1a gene regulation in mdr1a.fLUC reporter mice.

scientific article published on 26 March 2013

Bioimaging real-time PXR-dependent mdr1a gene regulation in mdr1a.fLUC reporter mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.113.203562
P932PMC publication ID3657110
P698PubMed publication ID23532932

P50authorTimothy SynoldQ78536675
P2093author name stringLong Gu
Jasmine Chen
Barry M Forman
Susan E Kane
P2860cites workSXR, a novel steroid and xenobiotic-sensing nuclear receptorQ22003995
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissuesQ24633406
The orphan nuclear receptor SXR coordinately regulates drug metabolism and effluxQ28186424
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligandsQ28375193
Biochemistry of multidrug resistance mediated by the multidrug transporterQ29616476
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificitiesQ33495468
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sitesQ33832954
Expression of a multidrug-resistance gene in human tumors and tissuesQ34586576
p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agentsQ36605767
Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cellsQ36715686
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissuesQ36768537
Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugsQ36795136
DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expressionQ36974192
A new model for studying tissue-specific mdr1a gene expression in vivo by live imagingQ37126122
Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.Q37233837
Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cellsQ38292631
A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expressionQ40399800
Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.Q40447949
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptorQ40768989
Modulation and prevention of multidrug resistance by inhibitors of P-glycoproteinQ41578162
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.Q41643433
Humanized xenobiotic response in mice expressing nuclear receptor SXR.Q41753938
Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.Q42930123
Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.Q54182645
The core promoter region of the P-glycoprotein gene is sufficient to confer differential responsiveness to wild-type and mutant p53.Q54238383
Species differences in responsiveness to 1,4-bis[2-(3,5-dichloropyridyloxy)]-benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activityQ70981860
Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell LinesQ72561176
Modulation of the multidrug resistance P-glycoprotein: detection with technetium-99m-sestamibi in vivoQ73164511
Detection of in vivo P-glycoprotein inhibition by PSC 833 using Tc-99m sestamibiQ77554192
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)438-445
P577publication date2013-03-26
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleBioimaging real-time PXR-dependent mdr1a gene regulation in mdr1a.fLUC reporter mice
P478volume345

Reverse relations

cites work (P2860)
Q26823286ABC transporters in fish species: a review
Q36251418Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models
Q38871905Imaging transporters: Transforming diagnostic and therapeutic development
Q36186153In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice.
Q37582128Inhibition of P-glycoprotein, multidrug resistance-associated protein 2 and cytochrome P450 3A4 improves the oral absorption of octreotide in rats with portal hypertension
Q35768413Molecular Imaging of Membrane Transporters' Activity in Cancer: a Picture is Worth a Thousand Tubes

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