Plexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met

scientific article published on 18 February 2010

Plexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1017192297
P356DOI10.1038/JID.2010.13
P932PMC publication ID3657133
P698PubMed publication ID20164843
P5875ResearchGate publication ID41466382

P2093author name stringGlynis Scott
Alex Fricke
Ihsin Kuo
Laurel Stevens
Lindy McClelland
Magali Williamson
P2860cites workInterplay between scatter factor receptors and B plexins controls invasive growthQ24295561
Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathwayQ24311648
Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapseQ24550822
Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responsesQ28189775
Functional regulation of semaphorin receptors by proprotein convertasesQ28203827
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEFQ28218379
The semaphorin 4D receptor controls invasive growth by coupling with MetQ28219215
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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesisQ28295920
Sema4D induces angiogenesis through Met recruitment by Plexin B1Q28301113
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Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals?Q33819069
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Plexins: axon guidance and signal transduction.Q34409838
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Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cellsQ35615400
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Plexin B1 is downregulated in renal cell carcinomas and modulates cell growth.Q40012559
ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.Q40048529
c-Met is a potentially new therapeutic target for treatment of human melanomaQ40150516
Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signalingQ40541604
Tyrosine kinase signal specificity: lessons from the HGF receptorQ40626260
Control of invasive growth by the HGF receptor familyQ41640439
Molecular profiling of the "plexinome" in melanoma and pancreatic cancerQ41692560
Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progressionQ42389733
Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1.Q43890944
Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 casesQ44185238
The prognostic significance of ulceration of cutaneous melanomaQ44362550
Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.Q45003993
The Sema domain of Met is necessary for receptor dimerization and activationQ46131945
Phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor growth and prognosis in patients with bladder cancer: correlation with matrix metalloproteinase-2 and -7 and E-cadherinQ46176116
Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.Q52183100
Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression.Q54790387
c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotypeQ77583076
Poor outcome in estrogen receptor-positive breast cancers predicted by loss of plexin B1Q79819362
Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cellsQ80595236
R-Ras fills another GAP in semaphorin signallingQ81368938
The use of sequential serial sectioning of thin melanomas in determining maximum Breslow depthQ81444186
Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectivelyQ81475161
Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysisQ82828740
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1636-1645
P577publication date2010-02-18
P1433published inJournal of Investigative DermatologyQ3186921
P1476titlePlexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met
P478volume130