Excitation Control: Balancing PSD-95 Function at the Synapse

scientific article published on 28 March 2008

Excitation Control: Balancing PSD-95 Function at the Synapse is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3389/NEURO.02.004.2008
P932PMC publication ID2526002
P698PubMed publication ID18946537
P5875ResearchGate publication ID23411661

P2093author name stringAlaa El-Husseini
Dove Keith
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Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophreniaQ24293245
Disorder-associated mutations lead to functional inactivation of neuroliginsQ24293552
The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processingQ24293639
Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptorsQ24298212
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autismQ24299042
The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axonsQ24299100
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autismQ24299133
Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanismsQ24303276
High frequency of neurexin 1beta signal peptide structural variants in patients with autismQ24306560
DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95Q24310200
A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brainQ24317295
Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteinsQ24322970
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroliginsQ24336796
Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disordersQ24337114
Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79Q24338492
Altered synaptic plasticity in a mouse model of fragile X mental retardationQ24530695
X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin familyQ24534259
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor numberQ24536358
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in miceQ24629938
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice.Q24648260
Neurexin-neuroligin signaling in synapse developmentQ24648824
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteinsQ24652235
Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activationQ24657890
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapsesQ24676816
GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering moleculesQ24681609
New players tip the scales in the balance between excitatory and inhibitory synapsesQ24796169
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2Q26269865
Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapsesQ26269981
Rapid redistribution of synaptic PSD-95 in the neocortex in vivoQ27335045
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this associationQ28115097
Evidence that fragile X mental retardation protein is a negative regulator of translationQ28117211
Mints as adaptors. Direct binding to neurexins and recruitment of munc18Q28141531
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanismsQ28141727
Targeting of PKA to glutamate receptors through a MAGUK-AKAP complexQ28143330
A developmental change in NMDA receptor-associated proteins at hippocampal synapsesQ28143367
Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neuronsQ28178909
Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1aQ28187839
The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor proteinQ28198177
Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102Q28208253
SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic densityQ28235849
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Molecular constituents of neuronal AMPA receptorsQ28593335
Model of autism: increased ratio of excitation/inhibition in key neural systemsQ29547530
Cortical inhibitory neurons and schizophreniaQ29547683
Neuroligin 1: a splice site-specific ligand for beta-neurexinsQ29614429
PSD-95 involvement in maturation of excitatory synapsesQ29616167
PDZ domain proteins of synapsesQ29616399
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome systemQ29617400
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responsesQ29618915
Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinasesQ30165018
Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95.Q30175431
Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifsQ30175793
Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatmentQ30428213
Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinasesQ31007885
On the cellular and network bases of epileptic seizures.Q31963797
Toward a developmental neurobiology of autism.Q33211115
Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity.Q33212164
The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95Q33717210
Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex.Q48469456
Distribution of glutamate receptors GluR 2/3 and NR1 in the developing rat cerebellum.Q48626919
Brain-derived neurotrophic factor mediates the activity-dependent regulation of inhibition in neocortical cultures.Q48683647
GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor.Q49082940
Activity-dependent plasticity of inhibitory and excitatory amino acid transmitter systems in cultured rat cerebral cortex.Q51620766
Development in the absence of spontaneous bioelectric activity results in increased stereotyped burst firing in cultures of dissociated cerebral cortex.Q51741720
Reduced synaptic clustering of GABA and glycine receptors in the retina of the gephyrin null mutant mouse.Q52541406
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticityQ59065408
Delayed response deficits produced by local injection of bicuculline into the dorsolateral prefrontal cortex in Japanese macaque monkeysQ69650035
Formation of mixed glycine and GABAergic synapses in cultured spinal cord neuronsQ73167497
Mismatched appositions of presynaptic and postsynaptic components in isolated hippocampal neuronsQ73168278
Rescue of gamma2 subunit-deficient mice by transgenic overexpression of the GABAA receptor gamma2S or gamma2L subunit isoformsQ74187521
Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4.Q77732966
Silencing of neuroligin function by postsynaptic neurexinsQ33731891
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampusQ33902823
Schizophrenia as a disorder of neurodevelopmentQ34132313
Diffusion dynamics of glycine receptors revealed by single-quantum dot trackingQ34270675
Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons.Q34289045
Increased numbers of coassembled PSD-95 to NMDA-receptor subunits NR2B and NR1 in human epileptic cortical dysplasiaQ34306912
Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95.Q34428734
Molecular genetics and animal models in autistic disorderQ34517515
Fragile X mental retardation protein in plasticity and diseaseQ34993137
The organization of cerebellar cortical circuitry revisited: implications for functionQ35064655
Role of astrocytes in the maintenance and modulation of glutamatergic and GABAergic neurotransmissionQ35074287
Synapse-specific regulation of AMPA receptor function by PSD-95.Q35540062
PSD-95 and PKC converge in regulating NMDA receptor trafficking and gatingQ35544322
GABA and Schizophrenia: A Review of Basic Science and Clinical StudiesQ35587241
Bringing order to the glutamate chaos in schizophreniaQ35601575
PSD-95 is required for activity-driven synapse stabilizationQ35676844
Neuropsychiatric symptoms of fragile X syndrome: pathophysiology and pharmacotherapyQ35871840
Seizures and epilepsy among children with language regression and autistic spectrum disordersQ35939602
Hippocampal gamma-frequency oscillations: from interneurones to pyramidal cells, and back.Q35946400
EEG in convulsive and nonconvulsive status epilepticusQ35980758
Synaptic integration in dendritic trees.Q36122101
Neuronal homeostasis through translational controlQ36281832
Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clusteringQ36301632
How to build a central synapse: clues from cell cultureQ36336004
Epilepsy: a review of selected clinical syndromes and advances in basic scienceQ36377765
Cell adhesion molecules at the synapseQ36486612
The postsynaptic densityQ36545830
Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo.Q36560553
Cell adhesion molecules: signalling functions at the synapseQ36589204
Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterationsQ36618870
A unified model of the presynaptic and postsynaptic changes during LTP at CA1 synapsesQ36619940
Autistic spectrum disorder: evaluating a possible contributing or causal role of epilepsyQ36653800
Inhibition of the dopamine D1 receptor signaling by PSD-95.Q37112269
A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroliginQ37535578
Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors induces calpain-mediated PSD-95/Dlg/ZO-1 protein degradation and AMPA receptor down-regulation in cultured hippocampal slicesQ28241303
Binding of neuroligins to PSD-95Q28247782
The neuroligin and neurexin families: from structure to function at the synapseQ28248001
Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometryQ28250422
Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion moleculesQ28250866
Activity-dependent scaling of quantal amplitude in neocortical neuronsQ28264163
Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmissionQ28264840
SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein familyQ28270354
Structures, alternative splicing, and neurexin binding of multiple neuroliginsQ28274307
Building excitatory and inhibitory synapses: balancing neuroligin partnershipsQ28278442
NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec populationQ28284048
Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive functionQ28285717
CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexinsQ28288628
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95Q28290055
An architectural framework that may lie at the core of the postsynaptic densityQ28293971
Effects of the GABA(A) receptor antagonists bicuculline and gabazine on stimulus-induced sharp wave-ripple complexes in adult rat hippocampus in vitroQ28297282
Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patientsQ28300296
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptorsQ28305869
Neuroligins determine synapse maturation and functionQ28505855
Identification of PSD-95 palmitoylating enzymesQ28508922
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expressionQ28566984
Control of excitatory and inhibitory synapse formation by neuroliginsQ28568459
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroliginQ28572335
A novel family of adhesion-like molecules that interacts with the NMDA receptorQ28572398
Neuroligin 2 is exclusively localized to inhibitory synapsesQ28576687
The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesisQ28578820
The interaction between Stargazin and PSD-95 regulates AMPA receptor surface traffickingQ28581802
cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold proteinQ28584074
Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alphaQ28585100
NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formationQ28586738
The fragile X mental retardation protein inhibits translation via interacting with mRNAQ28588486
Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activityQ28590039
Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticityQ28593050
Glutamate hyperexcitability and seizure-like activity throughout the brain and spinal cord upon relief from chronic glutamate receptor blockade in cultureQ39433893
Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum.Q39751809
Synaptic scaffolding molecule (S-SCAM) membrane-associated guanylate kinase with inverted organization (MAGI)-2 is associated with cell adhesion molecules at inhibitory synapses in rat hippocampal neuronsQ39752022
Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons.Q39757798
Vertebrate-specific sequences in the gephyrin E-domain regulate cytosolic aggregation and postsynaptic clusteringQ40156375
Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsyQ40279082
Postsynaptic density protein-95 regulates NMDA channel gating and surface expression.Q40493453
Identification of protein kinase C phosphorylation sites within the AMPA receptor GluR2 subunit.Q40773812
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiationQ41103770
Spontaneous firing as an epigenetic factor in brain development--physiological consequences of chronic tetrodotoxin and picrotoxin exposure on cultured rat neocortex neuronsQ41114271
Absence of expression of the FMR-1 gene in fragile X syndromeQ41669091
Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs.Q41732029
Interneuron and pyramidal cell interplay during in vitro seizure-like eventsQ41790633
Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression.Q42170154
Homeostatic plasticity during alcohol exposure promotes enlargement of dendritic spinesQ42506908
Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses.Q42670226
Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor functionQ43506207
Fragile X mice develop sensory hyperreactivity to auditory stimuliQ43574481
Molecular determinants of NMDA receptor internalizationQ43690729
Postsynaptic depolarization scales quantal amplitude in cortical pyramidal neurons.Q43744896
Theta stimulation polymerizes actin in dendritic spines of hippocampus.Q43766066
Synaptic strength regulated by palmitate cycling on PSD-95.Q43960568
Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice.Q43968745
Synaptic localization of GABA(A) receptor subunits in the substantia nigra of the rat: effects of quinolinic acid lesions of the striatumQ44051623
Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors.Q44066978
Lipid- and protein-mediated multimerization of PSD-95: implications for receptor clustering and assembly of synaptic protein networksQ44493540
Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptorsQ44550639
Developmental decrease in NMDA receptor desensitization associated with shift to synapse and interaction with postsynaptic density-95.Q44681131
Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons.Q44746561
Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity.Q44746570
N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4.Q44753883
Age- and region-specific imbalances of basal amino acids and monoamine metabolism in limbic regions of female Fmr1 knock-out miceQ44843160
Preferential accumulation of GABAA receptor gamma 2L, not gamma 2S, cytoplasmic loops at rat spinal cord inhibitory synapses.Q44964675
Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactionsQ45123828
Synaptic scaffolding molecule is involved in the synaptic clustering of neuroliginQ45157615
Delayed response deficit in monkeys by locally disturbed prefrontal neuronal activity by bicucullineQ45235333
SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapsesQ45345787
Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses.Q45976114
Horizontal spread of synchronized activity in neocortex and its control by GABA-mediated inhibitionQ46227789
Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.Q46305019
Intracellular recording reveals temporal integration in inferior colliculus neurons of awake batsQ46315797
PDZ proteins organize synaptic signaling pathwaysQ46332824
Stargazin modulates AMPA receptor gating and trafficking by distinct domainsQ46461380
Synapse-specific control of synaptic efficacy at the terminals of a single neuronQ46853657
A preformed complex of postsynaptic proteins is involved in excitatory synapse developmentQ46942984
Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene.Q47069992
The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses.Q48165507
Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrinQ48240102
Enhanced synaptic excitation-inhibition ratio in hippocampal interneurons of rats with temporal lobe epilepsyQ48281453
Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depressionQ48327079
Synaptic integration by V1 neurons depends on location within the orientation map.Q48432124
Potentiation of cortical inhibition by visual deprivation.Q48438986
Interaction between glutamate and GABA systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamus.Q48459076
P407language of work or nameEnglishQ1860
P304page(s)4
P577publication date2008-03-28
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titleExcitation Control: Balancing PSD-95 Function at the Synapse
P478volume1

Reverse relations

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