Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus

scientific article published on 7 July 2008

Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M802381200
P932PMC publication ID2529015
P698PubMed publication ID18606815

P2093author name stringMiguel A Lanaspa
Tomas Berl
Ana Andres-Hernando
Christopher J Rivard
P2860cites workTonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicityQ22008847
The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88Q24322912
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expressionQ24622498
Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear exportQ28238313
The expression of the gamma subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and phosphatidylinositol 3-kinase-dependent mechanismsQ33949441
Transcriptional regulation by changes in tonicityQ34319746
Adaptation of kidney medulla to hypertonicity: role of the transcription factor TonEBP.Q34600072
TonEBP transcriptional activator in the cellular response to increased osmolalityQ34795046
members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation.Q35200220
The tight junction protein, MUPP1, is up-regulated by hypertonicity and is important in the osmotic stress response in kidney cellsQ35962975
Hypertonic stress responseQ35986608
How tonicity regulates genes: story of TonEBP transcriptional activatorQ36492526
Nup358/RanBP2 attaches to the nuclear pore complex via association with Nup88 and Nup214/CAN and plays a supporting role in CRM1-mediated nuclear protein exportQ36572321
Tonicity-dependent regulation of osmoprotective genes in mammalian cellsQ36634899
Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive responseQ36900945
Nup214 is required for CRM1-dependent nuclear protein export in vivoQ38411212
TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicityQ39675201
Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cellsQ40556250
Adaptation of murine inner medullary collecting duct (IMCD3) cell cultures to hypertonicityQ40645546
Hydration status affects nuclear distribution of transcription factor tonicity responsive enhancer binding protein in rat kidney.Q40772846
Long-term adaptation of renal cells to hypertonicity: role of MAP kinases and Na-K-ATPaseQ40814088
The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expressionQ40854151
Osmotic regulation of gene expressionQ40918657
Cis- and trans-acting factors regulating transcription of the BGT1 gene in response to hypertonicityQ41045170
Regulation of the myo-inositol and betaine cotransporters by tonicityQ41066668
Regulation of gene expression by hypertonicityQ41387971
An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouseQ41531588
The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear exportQ42917946
Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats.Q44489653
Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes.Q46858890
The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NFkappaB activation in DrosophilaQ47070021
Regulation of nucleocytoplasmic trafficking of transcription factor OREBP/TonEBP/NFAT5.Q50726607
Cell and molecular biology of organic osmolyte accumulation in hypertonic renal cellsQ73599291
Silencing of TonEBP/NFAT5 transcriptional activator by RNA interferenceQ78826955
Downregulation of renal sodium transporters and tonicity-responsive enhancer binding protein by long-term treatment with cyclosporin AQ79485410
P433issue36
P407language of work or nameEnglishQ1860
P304page(s)25082-25090
P577publication date2008-07-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleNucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus
P478volume283