Transcriptional mutagenesis: causes and involvement in tumour development

scientific article published on March 2011

Transcriptional mutagenesis: causes and involvement in tumour development is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1051279968
P356DOI10.1038/NRC3006
P932PMC publication ID3659810
P698PubMed publication ID21346784
P5875ResearchGate publication ID49967469

P2093author name stringPaul W Doetsch
Damien Brégeon
P2860cites workBlockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosisQ71408610
Incorrect base insertion and prematurely terminated transcripts during T7 RNA polymerase transcription elongation past benzo[a]pyrenediol epoxide-modified DNAQ71850770
U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycleQ72185052
Translesional synthesis on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)Q72850833
Transcription bypass or blockage at single-strand breaks on the DNA template strand: effect of different 3' and 5' flanking groups on the T7 RNA polymerase elongation complexQ72891362
In vivo technique for determining transcriptional mutagenesisQ73044780
The oxidative DNA lesion 8,5'-(S)-cyclo-2'-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cellsQ73763148
Highly mutagenic bypass synthesis by T7 RNA polymerase of site-specific benzo[a]pyrene diol epoxide-adducted template DNAQ74531765
Phenotypic change caused by transcriptional bypass of uracil in nondividing cellsQ74672155
Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndromeQ81576390
RetractionQ81861539
Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosinesQ24535948
RNA-Seq: a revolutionary tool for transcriptomicsQ24596169
Mechanism of transcriptional stalling at cisplatin-damaged DNAQ27648994
Molecular Basis of Transcriptional Mutagenesis at 8-OxoguanineQ27657438
Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patientsQ28258349
Endogenous DNA damage in humans: a review of quantitative dataQ28259993
Genomic instability--an evolving hallmark of cancerQ28274009
Mutagenesis by apurinic/apyrimidinic sitesQ28300337
The current evidence for defective repair of oxidatively damaged DNA in Cockayne syndromeQ28307972
Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase IIQ28360336
Transcriptional mutagenesis induced by 8-oxoguanine in mammalian cellsQ28475782
Transcription-coupled DNA repair: two decades of progress and surprisesQ29614662
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodGQ29616532
HSP90 at the hub of protein homeostasis: emerging mechanistic insightsQ29616824
DNA replication fidelityQ29616841
NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).dA(anti) alignment at lesion siteQ68189284
An RNA polymerase mutant with reduced accuracy of chain elongationQ70315148
Removal of oxygen free-radical-induced 5',8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cellsQ30856746
RPA and ATR link transcriptional stress to p53Q33290206
Abasic sites and strand breaks in DNA cause transcriptional mutagenesis in Escherichia coli.Q33734755
Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetaseQ33819287
Role of oxidatively induced DNA lesions in human pathogenesisQ34091785
Error-prone repair DNA polymerases in prokaryotes and eukaryotesQ34131455
Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymeraseQ34342518
Repair and genetic consequences of endogenous DNA base damage in mammalian cellsQ34371854
Escherichia coli RNA and DNA polymerase bypass of dihydrouracil: mutagenic potential via transcription and replicationQ34660557
DNA polymerases and human diseaseQ34795963
Translesion synthesis by RNA polymerases: occurrence and biological implications for transcriptional mutagenesisQ35013058
Cell-selfish modes of evolution and mutations directed after transcriptional bypassQ35013064
DNA repair in terminally differentiated cellsQ35037473
RNA repair: damage controlQ35157587
RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factorsQ35191105
Oxidized messenger RNA induces translation errorsQ35576065
Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?Q35592874
Transcriptional bypass of bulky DNA lesions causes new mutant RNA transcripts in human cellsQ35752678
Genetic effects of oxidative DNA damage: comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coliQ35935140
Oxidized, deaminated cytosines are a source of C --> T transitions in vivoQ36005669
Nature and nurture - lessons from chemical carcinogenesisQ36014330
Use of an in vivo reporter assay to test for transcriptional and translational fidelity in yeastQ36021423
T7 RNA polymerase bypass of large gaps on the template strand reveals a critical role of the nontemplate strand in elongationQ36034196
Thymine glycol lesions terminate chain elongation by DNA polymerase I in vitroQ36089095
Oxidative stress and reactive oxygen speciesQ36117924
Hypothetical role of RNA damage avoidance in preventing human disease.Q36139539
Evidence from in vitro replication that O6-methylguanine can adopt multiple conformationsQ36274826
Is base excision repair a tumor suppressor mechanism?Q36371079
RNA polymerase encounters with DNA damage: transcription-coupled repair or transcriptional mutagenesis?Q36389652
Effects of abasic sites and DNA single-strand breaks on prokaryotic RNA polymerasesQ36421100
RNA polymerase bypass at sites of dihydrouracil: implications for transcriptional mutagenesisQ36556230
The mechanics of base excision repair, and its relationship to aging and diseaseQ36656724
Base excision repair, aging and health span.Q36853499
Base excision repair modulation as a risk factor for human cancersQ36880317
Transcription of DNA containing the 5-guanidino-4-nitroimidazole lesion by human RNA polymerase II and bacteriophage T7 RNA polymeraseQ36948658
Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymeraseQ36972108
8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cellsQ36999922
Base excision repair of oxidative DNA damage and association with cancer and agingQ37090426
Splice-site pairing is an intrinsically high fidelity process.Q37100836
Potential role of phenotypic mutations in the evolution of protein expression and stabilityQ37159074
DNA repair in mammalian cells: Transcription-coupled DNA repair: directing your effort where it's most neededQ37372523
The evolutionary consequences of erroneous protein synthesis.Q37393307
Highly error-free role of DNA polymerase eta in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cellsQ37416480
Replication of acetylaminofluorene-adducted plasmids in human cells: spectrum of base substitutions and evidence of excision repairQ37621481
Translational control in cancer.Q37717999
Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanineQ37732850
Transcription through 8-oxoguanine in DNA repair-proficient and Csb(-)/Ogg1(-) DNA repair-deficient mouse embryonic fibroblasts is dependent upon promoter strength and sequence contextQ40107274
The control of accuracy during protein synthesis in Escherichia coli and perturbations of this control by streptomycin, neomycin, or ribosomal mutationsQ40110360
In vitro replication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide adductsQ40393765
Mutation in resting cells: the role of endogenous DNA damage.Q41284321
Starvation-associated mutation in Escherichia coli: a spontaneous lesion hypothesis for "directed" mutationQ41661611
Transient reversal of RNA polymerase II active site closing controls fidelity of transcription elongationQ42658374
Global effects of mistranslation from an editing defect in mammalian cellsQ42834340
Editorial expression of concernQ42960154
DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structuresQ43084236
Site-directed mutagenesis for quantitation of base-base interactions at defined sitesQ43567455
Peroxynitrite-induced reactions of synthetic oligo 2'-deoxynucleotides and DNA containing guanine: formation and stability of a 5-guanidino-4-nitroimidazole lesionQ44014132
Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II. Implications for transcription-coupled DNA repair and transcriptional mutagenesis.Q44238573
Effects of DNA lesions on transcription elongation by T7 RNA polymeraseQ44342277
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutionsQ44480509
Transcriptional mutagenesis induced by uracil and 8-oxoguanine in Escherichia coli.Q44633186
Mapping adducts of DNA structural probes using transcription and primer extension approachesQ44829852
Transcription activities at 8-oxoG lesions in DNA.Q45067806
Site-specific mutagenesis using a gapped duplex vector: a study of translesion synthesis past 8-oxodeoxyguanosine in E. coliQ45199588
Host cell reactivation of plasmids containing oxidative DNA lesions is defective in Cockayne syndrome but normal in UV-sensitive syndrome fibroblastsQ46675864
Cancerous hyper-mutagenesis in p53 genes is possibly associated with transcriptional bypass of DNA lesionsQ47566790
Effects of nonbulky DNA base damages on Escherichia coli RNA polymerase-mediated elongation and promoter clearanceQ47724007
Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF.Q48292696
Reliable method for generating double-stranded DNA vectors containing site-specific base modifications.Q51577382
Mutagenesis by single site-specific arylamine-DNA adducts. Induction of mutations at multiple sites.Q53512360
Oxygen free radical damage to DNA. Translesion synthesis by human DNA polymerase eta and resistance to exonuclease action at cyclopurine deoxynucleoside residues.Q53990151
Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta.Q54055057
DNA polymerase V allows bypass of toxic guanine oxidation products in vivo.Q54446139
Assays for transcriptional mutagenesis in active genes.Q54462706
Counteraction by MutT protein of transcriptional errors caused by oxidative damage.Q54558346
Translesional synthesis on DNA templates containing a single abasic site. A mechanistic study of the "A rule".Q54565641
Template strand gap bypass is a general property of prokaryotic RNA polymerases: implications for elongation mechanisms.Q54576634
Efficient Bypass and Base Misinsertions at Abasic Sites by Prokaryotic RNA PolymerasesaQ54630140
Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.Q54710915
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filamentsQ64866811
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)218-227
P577publication date2011-03-01
P1433published inNature Reviews CancerQ641657
P1476titleTranscriptional mutagenesis: causes and involvement in tumour development
P478volume11

Reverse relations

cites work (P2860)
Q55416915A Genome-Wide Assay Specifies Only GreA as a Transcription Fidelity Factor in Escherichia coli.
Q33558016A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine
Q36431367A quantitative assay for assessing the effects of DNA lesions on transcription
Q40086673Accurate RNA consensus sequencing for high-fidelity detection of transcriptional mutagenesis-induced epimutations.
Q36724941BRCA1-Ku80 protein interaction enhances end-joining fidelity of chromosomal double-strand breaks in the G1 phase of the cell cycle
Q45961755Chemical Analysis of DNA Damage.
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q34727858DNA repair mechanisms in dividing and non-dividing cells
Q42149827Dissecting chemical interactions governing RNA polymerase II transcriptional fidelity
Q36436001Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human cells
Q54478463Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase: implications for bypass RNA synthesis on oxidative DNA lesions.
Q34507760Effects of Tet-mediated oxidation products of 5-methylcytosine on DNA transcription in vitro and in mammalian cells
Q36064927Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells
Q35754741Evidence for Retromutagenesis as a Mechanism for Adaptive Mutation in Escherichia coli
Q95300387Hypermutation in single-stranded DNA
Q89311743Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity
Q47363972In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities.
Q26824755Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?
Q37304675Mass Spectrometry-Based Quantitative Strategies for Assessing the Biological Consequences and Repair of DNA Adducts
Q46444604Mechanism of DNA alkylation-induced transcriptional stalling, lesion bypass, and mutagenesis
Q35062546Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions
Q39384000Mechanistic insights into transcription coupled DNA repair
Q38207228Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis
Q33606811Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis
Q90601695Next-Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk
Q34069546Nucleotide excision repair in Trypanosoma brucei: specialization of transcription-coupled repair due to multigenic transcription
Q52718714O6-methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function.
Q37194752Oxidative damage and mutagenesis in Saccharomyces cerevisiae: genetic studies of pathways affecting replication fidelity of 8-oxoguanine
Q41628843Position-dependent effects of regioisomeric methylated adenine and guanine ribonucleosides on translation
Q36440706Quantitative measurement of transcriptional inhibition and mutagenesis induced by site-specifically incorporated DNA lesions in vitro and in vivo
Q37174539RNA polymerase II acts as a selective sensor for DNA lesions and endogenous DNA modifications
Q38590733RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications
Q38117538RNA polymerase between lesion bypass and DNA repair
Q37287385Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions
Q42365650Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ.
Q87900920Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II
Q90318020The DNA damage response to transcription stress
Q38780730The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro
Q34711951Transcriptional bypass of regioisomeric ethylated thymidine lesions by T7 RNA polymerase and human RNA polymerase II.
Q35098098Transcriptional inhibition and mutagenesis induced by N-nitroso compound-derived carboxymethylated thymidine adducts in DNA.
Q27015664Transcriptional mutagenesis and its potential roles in the etiology of cancer and bacterial antibiotic resistance
Q26796502Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease
Q98386063Transcriptional mutagenesis dramatically alters genome-wide p53 transactivation landscape
Q40951385Transcriptional mutagenesis reduces splicing fidelity in mammalian cells.

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