An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s

scientific article published on 11 April 2016

An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/APS.2016.10
P932PMC publication ID4857547
P698PubMed publication ID27063220

P2093author name stringNing Li
Tao Chen
Zhong-Hua Chen
Ke-Zhi Zhang
Xue-Qin Lv
Na Long
Fei-Peng Zhang
Li-Shan Lin
Pei-Zhen Ye
Su-Xing Zhang
P2860cites workHigh-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction--tandem mass spectrometry method for CYP1A2 inhibition assessmentQ32079778
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-pointQ33347238
Drug-drug interactions of new active substances: mibefradil exampleQ33763217
Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivoQ35130543
Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratiosQ35860313
Leflunomide and warfarin interaction: case report and review of the literatureQ36484975
Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct.Q42028850
A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometryQ43513018
Cocktail-substrate approach-based high-throughput assay for evaluation of direct and time-dependent inhibition of multiple cytochrome P450 isoformsQ44188502
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomesQ44524934
Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipineQ44550572
Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?Q46125307
Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomesQ46686355
In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.Q46792862
The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of AmericaQ48024763
In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodiesQ58734935
Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequencesQ70591704
Cisapride and fatal arrhythmiaQ71133416
Tacrolimus/itraconazole interactions: a case report of ABO-incompatible living-related renal transplantationQ73011042
Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populationsQ73393390
An in vitro, high throughput, seven CYP cocktail inhibition assay for the evaluation of new chemical entities using LC-MS/MSQ83096106
Reliable high-throughput method for inhibition assay of 8 cytochrome P450 isoforms using cocktail of probe substrates and stable isotope-labeled internal standardsQ83877000
Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuseQ87543493
P433issue5
P304page(s)708-718
P577publication date2016-04-11
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleAn improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s
P478volume37

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cites work (P2860)
Q93194413Evaluation of Cytochrome P450 Selectivity for Hydralazine as an Aldehyde Oxidase Inhibitor for Reaction Phenotyping
Q88779209Evaluation of In Vitro Cytochrome P450 Inhibition and In Vitro Fate of Structurally Diverse N-Oxide Metabolites: Case Studies with Clozapine, Levofloxacin, Roflumilast, Voriconazole and Zopiclone
Q90645483Hepatic Enzymes Relevant to the Disposition of (-)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC

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