Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors.

scientific article published on 4 April 2016

Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/APS.2016.11
P932PMC publication ID4857548
P698PubMed publication ID27041462

P50authorMingyue ZhengQ43370955
P2093author name stringDong-Mei Zhao
Mao-Sheng Cheng
Bing Xiong
Jing Ai
Xia Peng
Jing-Kang Shen
Mei-Yu Geng
Dan-Qi Chen
Yin-Chun Ji
Yu-Chi Ma
Tong-Chao Liu
P2860cites workIdentification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene ProductQ24310794
The protein kinase complement of the human genomeQ24324497
Discovery of 4-azaindoles as novel inhibitors of c-Met kinaseQ27654792
Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)Q27671432
Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.Q27853074
Met, metastasis, motility and moreQ28235183
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracyQ28251042
Invasive growth: a MET-driven genetic programme for cancer and stem cellsQ28253680
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyQ28285975
Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculationsQ33551889
alpha2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cellsQ33552709
Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapyQ33652455
Yhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cellsQ33823715
Invasive growth: from development to metastasisQ34584035
Drug development of MET inhibitors: targeting oncogene addiction and expedienceQ34782774
Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesisQ37065772
Lentivirus-mediated RNA silencing of c-Met markedly suppresses peritoneal dissemination of gastric cancer in vitro and in vivoQ37729958
MET signalling: principles and functions in development, organ regeneration and cancerQ37811895
Targeting receptor tyrosine kinase MET in cancer: small molecule inhibitors and clinical progressQ38169807
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity.Q39702478
c-Met is essential for wound healing in the skinQ39735911
Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domainsQ40178199
Scatter factor is a fibroblast-derived modulator of epithelial cell mobilityQ42807925
Molecular cloning of a new transforming gene from a chemically transformed human cell line.Q45345810
Design and optimization of a series of 1-sulfonylpyrazolo[4,3-b]pyridines as selective c-Met inhibitors.Q53621099
Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene AddictionQ58164795
Series Introduction: Invasive growth: from development to metastasisQ58165151
c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotypeQ77583076
Clinical significance of c-met oncogene alterations in human colorectal cancerQ77796048
P433issue5
P304page(s)698-707
P577publication date2016-04-04
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleDiscovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors
P478volume37

Reverse relations

cites work (P2860)
Q57471713Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling
Q41344857Clinicopathological and prognostic significance of c-Met overexpression in breast cancer
Q58129391[Design and synthesis of imidazo-fused heterocycles derivatives and their anti-tumor activity against breast cancer in mice]

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