Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity

scientific article published on January 2007

Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0079-6123(06)61003-0
P698PubMed publication ID17618968

P50authorDavid F MeaneyQ96951457
P2093author name stringSteven J Bernstein
Catherine R von Reyn
Jennifer M Spaethling
Pallab Singh
William J Miller
Donna M Geddes-Klein
Mahlet Mesfin
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High tolerance and delayed elastic response of cultured axons to dynamic stretch injury.Q40952238
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Intracellular Free Calcium Dynamics in Stretch‐Injured AstrocytesQ42455751
Alterations in calcium-mediated signal transduction after traumatic injury of cortical neuronsQ42483427
Traumatic injury of cortical neurons causes changes in intracellular calcium stores and capacitative calcium influxQ43508757
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Repeated mild injury causes cumulative damage to hippocampal cellsQ44214938
NMDA receptor activation contributes to a portion of the decreased mitochondrial membrane potential and elevated intracellular free calcium in strain-injured neuronsQ44287950
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Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors.Q44376599
Traumatic neuronal injury in vitro is attenuated by NMDA antagonistsQ44548235
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Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytesQ44786452
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Astrocytes generate isoprostanes in response to trauma or oxygen radicalsQ44872428
Traumatically induced axotomy adjacent to the soma does not result in acute neuronal death.Q44885921
Mechanical injury modulates AMPA receptor kinetics via an NMDA receptor-dependent pathwayQ44903589
S100B protein is released by in vitro trauma and reduces delayed neuronal injuryQ44906922
Myelinated and unmyelinated axons of the corpus callosum differ in vulnerability and functional recovery following traumatic brain injuryQ44913018
Mechanoporation induced by diffuse traumatic brain injury: an irreversible or reversible response to injury?Q44918318
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Traumatically induced altered membrane permeability: its relationship to traumatically induced reactive axonal changeQ45085305
A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanicsQ45091283
Stretch-induced injury of cultured neuronal, glial, and endothelial cells. Effect of polyethylene glycol-conjugated superoxide dismutaseQ45096499
Mechanical perturbation of cultured cortical neurons reveals a stretch-induced delayed depolarizationQ45098392
Reduction of voltage-dependent Mg2+ blockade of NMDA current in mechanically injured neuronsQ45101676
Inhibition of the electrogenic Na pump underlies delayed depolarization of cortical neurons after mechanical injury or glutamateQ45103307
Alterations in phosphatidylcholine metabolism of stretch-injured cultured rat astrocytes.Q45103987
Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injuryQ45141097
Spreading depression expands traumatic injury in neocortical brain slicesQ45270194
Tissue-level thresholds for axonal damage in an experimental model of central nervous system white matter injuryQ46350504
Neuroprotective effects of novel small peptides in vitro and after brain injuryQ46502239
Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.Q46852738
Neuroprotective effects of selective group II mGluR activation in brain trauma and traumatic neuronal injuryQ46965046
Mechanisms and consequences of neuronal stretch injury in vitro differ with the model of traumaQ46965055
Increased Jun Immunoreactivity in anIn VitroModel of Mammalian Spinal Neuron Physical InjuryQ47802578
Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.Q48109065
Physiologic, histopathologic, and cineradiographic characterization of a new fluid-percussion model of experimental brain injury in the rat.Q48143953
Controlled cortical impact: a new experimental brain injury modelQ48147747
P304page(s)27-39
P577publication date2007-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inProgress in Brain ResearchQ15800382
P1476titleLinking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity
P478volume161

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cites work (P2860)
Q37685775Addressing the needs of traumatic brain injury with clinical proteomics
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Q33979659Principal component analysis of dynamic relative displacement fields estimated from MR images.
Q27013700The mechanics of traumatic brain injury: a review of what we know and what we need to know for reducing its societal burden

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