Anti-CD40 antibody and toll-like receptor 3 ligand restore dendritic cell-mediated anti-tumor immunity suppressed by morphine

scientific article published on 15 January 2016

Anti-CD40 antibody and toll-like receptor 3 ligand restore dendritic cell-mediated anti-tumor immunity suppressed by morphine is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID4859650
P698PubMed publication ID27186393

P50authorYing-Cheng ChiangQ56748561
P2093author name stringChi-An Chen
Wen-Fang Cheng
Yu-Li Chen
Ming-Cheng Chang
Wei-Zen Sun
Ya-Jung Cheng
Yu-Wei Jen
P2860cites workImmunosuppressive effects of morphine on immune responses in miceQ72600475
Tumor-infiltrating dendritic cells are defective in their antigen-presenting function and inducible B7 expression. A role in the immune tolerance to antigenic tumorsQ73672337
The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cellsQ74055104
CD40 engagement strongly induces CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward Th1Q82739590
The CD40 agonist antibody CP-870,893 enhances dendritic cell and B-cell activity and promotes anti-tumor efficacy in SCID-hu miceQ83822496
Altered subcellular signaling in murine peritoneal macrophages upon chronic morphine exposureQ83915735
Morphine reciprocally regulates IL-10 and IL-12 production by monocyte-derived human dendritic cells and enhances T cell activationQ24677648
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Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCsQ34332369
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Depletion of regulatory T lymphocytes reverses the imbalance between pro- and anti-tumor immunities via enhancing antigen-specific T cell immune responsesQ34451999
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LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTPQ36668282
In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cellsQ37369512
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Cord blood stem-cell-derived dendritic cells generate potent antigen-specific immune responses and anti-tumour effectsQ39408982
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Morphine-sparing effect by COX-1 inhibitor sustains analgesic function without compromising antigen-specific immunity and antitumor effect of naked DNA vaccineQ39717158
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Connective tissue growth factor linked to the E7 tumor antigen generates potent antitumor immune responses mediated by an antiapoptotic mechanism.Q39999888
Chimeric DNA vaccine reverses morphine-induced immunosuppression and tumorigenesis.Q40378112
Enhancement of Sindbis virus self-replicating RNA vaccine potency by linkage of Mycobacterium tuberculosis heat shock protein 70 gene to an antigen gene.Q40807324
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Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity studyQ41929905
Overexpression and immunosuppressive functions of transforming growth factor 1, vascular endothelial growth factor and interleukin-10 in epithelial ovarian cancerQ42984756
Effects of tramadol on T lymphocyte proliferation and natural killer cell activity in rats with sciatic constriction injuryQ43588875
Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophagesQ44470136
Cell-type specific activation of p38 and ERK mediates calcitonin gene-related peptide involvement in tolerance to morphine-induced analgesiaQ45158980
Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infectionQ45195944
The role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-OH kinase signal transduction pathways in CD40 ligand-induced dendritic cell activation and expansion of virus-specific CD8+ T cell mQ45643175
Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathwayQ46792408
Dendritic cells in peripheral blood of patients with breast and lung cancer--a pilot study.Q47875947
Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production.Q52547955
Morphine decreases early peritoneal innate immunity responses in Swiss–Webster and C57BL6/J mice through the inhibition of mast cell TNF-α releaseQ63433414
Morphine-induced immunomodulation is not related to serum morphine concentrationsQ68095897
Opiate receptor mediated regulation of the immune response in vivoQ69819445
P433issue2
P921main subjecttoll-like receptorQ408004
dendritic cellQ506253
P304page(s)157-172
P577publication date2016-01-15
P1433published inAmerican Journal of Cancer ResearchQ17511667
P1476titleAnti-CD40 antibody and toll-like receptor 3 ligand restore dendritic cell-mediated anti-tumor immunity suppressed by morphine
P478volume6