Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling

scientific article published on May 2016

Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2016.04.003
P932PMC publication ID4860254
P698PubMed publication ID27153536

P2093author name stringWei Wang
Benjamin A Garcia
Akriti Kharbanda
Xing-Jun Cao
Eric S Witze
Ewa Stypulkowski
Kristin B Runkle
P2860cites workDHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-RasQ24306928
2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitroQ24657239
Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell BehaviorQ27313355
Receptor downregulation and multivesicular-body sortingQ28131720
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencingQ28275103
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substratesQ28624927
Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomicsQ29615818
Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapyQ33943421
Targeting the EGFR signaling pathway in cancer therapyQ34246558
Palmitoylation and depalmitoylation dynamics at a glanceQ34329570
ErbB/HER protein-tyrosine kinases: Structures and small molecule inhibitorsQ34424780
Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapiesQ35623965
Palmitoylation controls recycling in lysosomal sorting and traffickingQ36407241
Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation.Q36544282
Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tailsQ37002174
Endosomes: a legitimate platform for the signaling trainQ37394435
DHHC palmitoyl transferases: substrate interactions and (patho)physiologyQ37851213
Protein palmitoylation and subcellular traffickingQ37912382
The EGFR family: not so prototypical receptor tyrosine kinasesQ38201344
Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanismQ73163038
P433issue3
P304page(s)385-396
P577publication date2016-05-01
P1433published inMolecular CellQ3319468
P1476titleInhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling
P478volume62

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cites work (P2860)
Q92644556Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression
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Q92487810CD317 Activates EGFR by Regulating Its Association with Lipid Rafts
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Q33809433FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and G
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