CaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity

scientific article published on April 2013

CaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.3861-12.2013
P932PMC publication ID3666179
P698PubMed publication ID23575848

P2093author name stringMichael T Marr
Amy E Ghiretti
Suzanne Paradis
Katelyn Kenny
P2860cites workPhosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activityQ24303682
Effects of phosphorylation on function of the Rad GTPaseQ24531157
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPasesQ24630460
Characterization of a calmodulin kinase II inhibitor protein in brainQ24653028
Mechanisms of CaMKII action in long-term potentiationQ26998387
Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIαQ27332408
RGK family G-domain:GTP analog complex structures and nucleotide-binding propertiesQ27673421
Structure of the GDP-bound G domain of the RGK protein Rem2Q27681075
The molecular basis of CaMKII function in synaptic and behavioural memoryQ28216850
Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase IIQ28235839
Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKIIQ28571729
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPasesQ28575334
Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK)Q28587761
Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulationsQ29615346
Dendritic organization in the neurons of the visual and motor cortices of the catQ29616515
Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatasesQ29617542
The function of activity-regulated genes in the nervous system.Q33686078
Autonomous CaMKII can promote either long-term potentiation or long-term depression, depending on the state of T305/T306 phosphorylationQ33991390
Mechanisms of specificity in neuronal activity-regulated gene transcriptionQ35100259
The Control of Dendrite DevelopmentQ35558409
Neuronal Polarity and TraffickingQ35558424
An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development.Q35945470
A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain.Q36082096
The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodelingQ36478004
Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expressionQ36665572
CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription couplingQ36993332
Phosphorylation meets nuclear import: a reviewQ37823682
Analysis of CaM-kinase signaling in cellsQ37870268
Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.Q38307319
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPaseQ38330207
The GTPase Rem2 regulates synapse development and dendritic morphologyQ38366331
Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport.Q40112762
RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain.Q40170542
CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channelsQ40274743
Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2.Q40429169
Calcium activation of ERK mediated by calmodulin kinase I.Q40554327
Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activityQ41430917
Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade.Q42949900
A CaMKII-NeuroD signaling pathway specifies dendritic morphogenesis.Q44740477
Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I.Q44844953
Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2.Q47602516
Inhibitors of calmodulin-dependent protein kinase are nonspecific blockers of voltage-dependent K+ channels in vascular myocytes.Q48131672
Stabilization of dendritic arbor structure in vivo by CaMKII.Q48553819
Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcriptionQ48567243
Signaling mechanisms underlying reversible, activity-dependent dendrite formationQ48567257
Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism.Q52046731
Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface densityQ81375760
P4510describes a project that usesImageJQ1659584
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)6504-6515
P577publication date2013-04-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleCaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity
P478volume33

Reverse relations

cites work (P2860)
Q38994543A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors
Q31134091A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity
Q39417855Localization of rem2 in the central nervous system of the adult rainbow trout (Oncorhynchus mykiss).
Q26851882Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins
Q38979545NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac
Q87836430Nerve injury induces a Gem-GTPase-dependent downregulation of P/Q-type Ca2+ channels contributing to neurite plasticity in dorsal root ganglion neurons
Q57780301Neural architecture: from cells to circuits
Q50877224Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice.
Q38534669Regulation of dendrite morphogenesis by extrinsic cues
Q37733140Rem2 in the bullfrog (Rana catesbeiana): Patterns of expression within the central nervous system and brain expression at different ontogenetic stages
Q37409984Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo.
Q50078213Rem2 signaling affects neuronal structure and function in part by regulation of gene expression.
Q55222868Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits.
Q36841074Rem2, a member of the RGK family of small GTPases, is enriched in nuclei of the basal ganglia.
Q47157167TDP-43 misexpression causes defects in dendritic growth
Q90721503The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity
Q83230266The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest
Q38153990The effects of early-life seizures on hippocampal dendrite development and later-life learning and memory

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