The Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability.

scientific article published on 18 February 2016

The Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M115.699108
P932PMC publication ID4861479
P698PubMed publication ID26893378

P50authorYilun MaQ87323085
P2093author name stringRichard A Cerione
Marc A Antonyak
Jingwen Zhang
Garima Singh
P2860cites workTransglutaminase 2 undergoes a large conformational change upon activationQ21092747
Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealingQ24537302
Global rigid body modeling of macromolecular complexes against small-angle scattering dataQ24538734
Transglutaminase is a tumor cell and cancer stem cell survival factorQ26799862
Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activityQ27638096
The molecular basis for the regulation of the cap-binding complex by the importinsQ27656958
Intron-exon swapping of transglutaminase mRNA and neuronal Tau aggregation in Alzheimer's diseaseQ28118540
Differential expression of multiple transglutaminases in human brain. Increased expression and cross-linking by transglutaminases 1 and 2 in Alzheimer's diseaseQ28145899
Gh: a GTP-binding protein with transglutaminase activity and receptor signaling functionQ28578829
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptorQ29618661
CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic CoordinatesQ29642130
The v-Src SH3 Domain Binds Phosphatidylinositol 3'-KinaseQ30194840
Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cellsQ30499127
EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activationQ33667547
Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic interventionQ34927039
Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cellsQ35065126
Two isoforms of tissue transglutaminase mediate opposing cellular fatesQ35157424
Transglutaminase 2: a molecular Swiss army knifeQ35693361
The importance of Src signaling in sarcomaQ35802929
Tissue transglutaminase in normal and abnormal wound healing: review articleQ35854245
Transglutaminase 2 inhibitors and their therapeutic role in disease statesQ35989247
Expression of tissue transglutaminase in skeletal tissues correlates with events of terminal differentiation of chondrocytesQ36233145
Tissue transglutaminase (TG2)--a wound response enzyme.Q36251098
Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nucleiQ36395820
Calcium and cell death: the mitochondrial connection.Q37056461
A mechanism for the upregulation of EGF receptor levels in glioblastomasQ37091283
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasionQ37258496
Transglutaminase activation in neurodegenerative diseases.Q37352964
Potential of transglutaminase 2 as a therapeutic target.Q37776508
TGM2 and implications for human disease: role of alternative splicingQ38070504
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathwayQ38170894
Tissue array-based expression of transglutaminase-2 in human breast and ovarian cancerQ38311664
A novel mechanism by which tissue transglutaminase activates signaling events that promote cell survivalQ38608634
GTP-binding-defective forms of tissue transglutaminase trigger cell deathQ40041960
TransglutaminasesQ40082696
Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-kappaB inactivationQ40208016
Importance of Ca(2+)-dependent transamidation activity in the protection afforded by tissue transglutaminase against doxorubicin-induced apoptosisQ40214283
Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibit doxorubicin-induced apoptosis in human breast cancer cellsQ40532129
Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitroQ41634983
Transglutaminase 2 facilitates or ameliorates HIF signaling and ischemic cell death depending on its conformation and localizationQ42403952
Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegenerationQ43819036
Injury-induced "switch" from GTP-regulated to novel GTP-independent isoform of tissue transglutaminase in the rat spinal cordQ44028734
Tissue transglutaminase is increased in Huntington's disease brainQ45299289
Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy.Q48372615
Importance of syndecan-4 and syndecan -2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase-fibronectin complex.Q54636907
Site-directed mutagenesis of human tissue transglutaminase: Cys-277 is essential for transglutaminase activity but not for GTPase activity.Q54651465
Automated matching of high- and low-resolution structural modelsQ56444545
Expression of tissue transglutaminase in cultured monocytic leukemia (THP-1) cells during differentiationQ69875572
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptorQ78069495
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)9119-9132
P577publication date2016-02-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability
P478volume291