The biology of cancer stem cells

scientific article published on January 2007

The biology of cancer stem cells is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1146/ANNUREV.CELLBIO.22.010305.104154
P698PubMed publication ID17645413
P5875ResearchGate publication ID6194047

P50authorYohei ShimonoQ57712498
P2093author name stringMichael F Clarke
Dalong Qian
Neethan A Lobo
P2860cites workExtension of life-span by introduction of telomerase into normal human cellsQ24336088
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastomaQ28286168
P921main subjectneoplastic stem cellsQ1638475
P304page(s)675-699
P577publication date2007-01-01
P1433published inAnnual Review of Cell and Developmental BiologyQ4497277
P1476titleThe biology of cancer stem cells
P478volume23

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cites work (P2860)
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Q38316551In vitro evaluation of sialyl Lewis X relationship with head and neck cancer stem cells
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Q36299678Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases
Q38206476Influences of vascular niches on hematopoietic stem cell fate
Q34027988Inhibition of breast cancer resistance protein (ABCG2) in human myeloid dendritic cells induces potent tolerogenic functions during LPS stimulation
Q35709668Inhibition of hedgehog signaling reduces the side population in human malignant mesothelioma cell lines
Q64996870Interpretation of interlocking key issues of cancer stem cells in malignant solid tumors.
Q35572241Intratumoral heterogeneity in a Trp53-null mouse model of human breast cancer
Q37436121Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature
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Q28486138Krüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells
Q36452206Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells
Q38857274LGR5 promotes the proliferation of colorectal cancer cells via the Wnt/β-catenin signaling pathway
Q37904866Lessons from common markers of tumor-initiating cells in solid cancers
Q35405142Lgr5 is a potential prognostic marker in patients with cervical carcinoma
Q36995745Limitations of the cancer stem cell theory
Q47230976Liposomal co-delivery-based quantitative evaluation of chemosensitivity enhancement in breast cancer stem cells by knockdown of GRP78/CLU.
Q101476060LncRNA NEAT1 remodels chromatin to promote the 5-Fu resistance by maintaining colorectal cancer stemness
Q37536186Localization and Molecular Characterization of human Breast Cancer Initiating Cells from heterogeneous population of Breast Cancer Mesenchymal Stem cells by Immunofluorescence Microscopy
Q54959875Long Non-Coding RNAs Dysregulation and Function in Glioblastoma Stem Cells.
Q53219514Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1.
Q38707291Long-Lived Epidermal Cancer-Initiating Cells
Q33958108Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells
Q83367156Loss of heterozygosity of the tumor suppressor gene Tg737 in the side population cells of hepatocellular carcinomas is associated with poor prognosis
Q98623252Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation
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Q38035056Lung cancer stem cells: tumor biology and clinical implications
Q47224069Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway.
Q64226720Meeting the Challenge of Targeting Cancer Stem Cells
Q61800283Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
Q37125569Mesenchymal Cells of the Intestinal Lamina Propria
Q50001260Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells.
Q35884622Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells
Q24644251MicroRNA let-7: an emerging next-generation cancer therapeutic
Q38223219MicroRNAs in cancer stem cells: current status and future directions
Q43065072Minimizing the risk of cancer: tissue architecture and cellular replication limits
Q36908928Minireview: stem cell contribution to ovarian development, function, and disease
Q90177348Mitotic quiescence in hepatic cancer stem cells: An incognito mode
Q36486600Mitotic spindle (DIS)orientation and DISease: cause or consequence?
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Q28264900Modification of mammalian reoviruses for use as oncolytic agents
Q94547415Molecular Insights Into Therapeutic Potential of Autophagy Modulation by Natural Products for Cancer Stem Cells
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Q33917943Molecular imaging of metastatic potential
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Q39864877Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype
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Q88912678Novel triple‑positive markers identified in human non‑small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristics
Q54658264Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway
Q30380301Of drug administration, war and oïkos: mediating cancer with nanomedicines.
Q35597082Oncolytic virotherapy for ovarian cancer
Q52847842Organoid Culture of Human Cancer Stem Cells.
Q64040226Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases
Q37033992Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype
Q41771086Overcoming Multidrug Resistance in Cancer Stem Cells
Q35324465PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation
Q35048897PLK1 inhibition down-regulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster
Q55280786PanCD44 Immunohistochemical Evaluation in Prostatectomies from Patients with Adenocarcinoma.
Q33648865Pancreatic Cancer Cells Resistant to Chemoradiotherapy Rich in “Stem-Cell-Like” Tumor Cells
Q92705174Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma
Q51398885PlGF Knockdown Decreases Tumorigenicity and Stemness Properties of Spheroid Body Cells Derived from Gastric Cancer Cells.
Q27438119Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer
Q33838680Postgenomic technologies targeting the Wnt signaling network
Q38876097Profilin 2 promotes migration, invasion, and stemness of HT29 human colorectal cancer stem cells
Q61453118Prognostic Value of CD133 and SOX2 in Advanced Cancer
Q41332330Prognostic impact of CD133 expression in Endometrial Cancer Patients
Q36661089Prognostic significance of stem cell marker CD133 determined by promoter methylation but not by immunohistochemical expression in malignant gliomas
Q34467221Prognostic value of CD133 expression in stage I lung adenocarcinomas
Q36503093Prognostic value of cancer stem cell marker CD133 expression in esophageal carcinoma: A meta-analysis
Q35055205Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis
Q34552547Progress in understanding melanoma propagation
Q39424549Prostate Cancer Stem Cell Markers Drive Progression, Therapeutic Resistance, and Bone Metastasis
Q54291180Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice.
Q38027219Proteomics in studying cancer stem cell biology
Q34712278Pulmonary Adenocarcinoma in Malignant Pleural Effusion Enriches Cancer Stem Cell Properties during Metastatic Cascade
Q36335412Putative cancer-initiating stem cells in cell culture models for molecular subtypes of clinical breast cancer
Q90480120Quantification of the Underlying Mechanisms and Relationships Among Cancer, Metastasis, and Differentiation and Development
Q47097935RKIP reduction enhances radioresistance by activating the Shh signaling pathway in non-small-cell lung cancer
Q91666331RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer
Q53543624Radiation responses of stem cells: targeted and non-targeted effects.
Q30540998Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells
Q38075424Redox regulation in stem-like cancer cells by CD44 variant isoforms.
Q36960756Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities
Q37458003Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling
Q36700030Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151.
Q35642076Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila
Q37707515Regulation of stem cell function by protein ubiquitylation
Q28072716Regulatory mechanisms of microRNAs in lung cancer stem cells
Q35643960Relation of stem cell markers ALDH1 and CD44 with clinicopathological factors in urothelial carcinomas of urinary bladder.
Q34154365Remodeling of endogenous mammary epithelium by breast cancer stem cells
Q39458600Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT-SSX2.
Q28539523Response of breast cancer cells and cancer stem cells to metformin and hyperthermia alone or combined
Q91705763Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer
Q28541242Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/β-catenin signaling pathway
Q37463413Revisiting the seed and soil in cancer metastasis
Q41613353Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway.
Q52666361Role of Akt Isoforms Controlling Cancer Stem Cell Survival, Phenotype and Self-Renewal.
Q47104789Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
Q37328360Role of oxidative stress in stem, cancer, and cancer stem cells.
Q36076413SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer
Q53224289SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans.
Q90400267STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model
Q64884695SUN2: A potential therapeutic target in cancer.
Q28279753Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers
Q64243717Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
Q38768259Secreted Frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines.
Q38110297Seed, soil, and beyond: The basic biology of brain metastasis
Q57282976Serially transplantable mammary epithelial cells express the Thy-1 antigen
Q36057892Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10
Q35233174Side population rather than CD133(+) cells distinguishes enriched tumorigenicity in hTERT-immortalized primary prostate cancer cells
Q92971685Signaling pathways involved in chronic myeloid leukemia pathogenesis: The importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells
Q27023399Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis
Q38980557Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals
Q42733062Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness.
Q34030957Slug and Sox9 cooperatively determine the mammary stem cell state
Q28481728Small molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer
Q38088823Smoothened antagonists: a promising new class of antitumor agents
Q34022318Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics
Q38904884Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer
Q59792939Sox2 is associated with cancer stem-like properties in colorectal cancer
Q47726425Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells Under BMP4 and Noggin Influence.
Q28742459Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment
Q37399843Squelching glioblastoma stem cells by targeting REST for proteasomal degradation
Q41008891Stem Cells in Translational Cancer Research
Q35823330Stem cell protein Piwil1 endowed endometrial cancer cells with stem-like properties via inducing epithelial-mesenchymal transition
Q37769649Stem cells and cancer of the stomach and intestine
Q33989211Stem cells in gastroenterology and hepatology
Q37193824Stemming cancer: functional genomics of cancer stem cells in solid tumors
Q81234707Stochastic model of the formation of cancer metastases via cancer stem cells
Q37612047Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression.
Q38785852Suppressing H19 Modulates Tumorigenicity and Stemness in U251 and U87MG Glioma Cells
Q28076462Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment
Q38114000Targeted therapy aimed at cancer stem cells: Wilms' tumor as an example
Q35269551Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8⁺ T cells.
Q41463557Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer.
Q39321673Targeting Lung Cancer Stem Cells: Research and Clinical Impacts
Q89667670Targeting cancer stem cell pathways for cancer therapy
Q48179398Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene.
Q89897161Targeting cancer stem cells from a metabolic perspective
Q35334436Targeting cell cycle regulators in hematologic malignancies.
Q42317503Targeting epithelial-mesenchymal transition and cancer stem cells for chemoresistant ovarian cancer
Q26775961Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy
Q34555251Targeting stem cells-clinical implications for cancer therapy
Q28078716Targeting the VEGF-C/VEGFR3 axis suppresses Slug-mediated cancer metastasis and stemness via inhibition of KRAS/YAP1 signaling
Q36394964Targeting the perpetrator: breast cancer stem cell therapeutics
Q34069482Telomerase-immortalized human mammary stem/progenitor cells with ability to self-renew and differentiate
Q47612537Telomeres and Telomerase in Hematopoietic Dysfunction: Prognostic Implications and Pharmacological Interventions.
Q39071403The Cellular Origin and Evolution of Breast Cancer
Q36736056The Effect of X-Ray and Heavy Ions Radiations on Chemotherapy Refractory Tumor Cells.
Q37134198The Emerging Picture of Human Breast Cancer as a Stem Cell-based Disease.
Q57584305The Role of Biomaterials on Cancer Stem Cell Enrichment and Behavior
Q35684577The Role of Cancer Stem Cells in the Organ Tropism of Breast Cancer Metastasis: A Mechanistic Balance between the "Seed" and the "Soil"?
Q38893314The Role of Stem Cell DNA Methylation in Colorectal Carcinogenesis
Q27005618The Role of microRNAs in Stemness of Cancer Stem Cells
Q38365386The Secret Role of microRNAs in Cancer Stem Cell Development and Potential Therapy: A Notch-Pathway Approach
Q37787403The Tumor Microenvironment and DNA Repair
Q26770007The Warburg effect and drug resistance
Q38092648The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics
Q53219888The attenuation of epithelial to mesenchymal transition and induction of anoikis by gigantol in human lung cancer H460 cells.
Q34681351The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
Q90746446The biological implications of Yin Yang 1 in the hallmarks of cancer
Q38613304The biology and clinical implications of prostate cancer dormancy and metastasis
Q28244178The cancer stem cell niche--there goes the neighborhood?
Q36854372The cancer stem cell paradigm: a new understanding of tumor development and treatment
Q55463049The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling.
Q35566484The crossroads between cancer stem cells and aging.
Q37649670The development of a malignant tumor is due to a desperate asexual self-cloning process in which cancer stem cells develop the ability to mimic the genetic program of germline cells
Q36912649The differentiation of pancreatic tumor-initiating cells by vitronectin can be blocked by cilengitide
Q34310378The epigenetics of epithelial-mesenchymal plasticity in cancer
Q36730830The harmonies played by TGF-β in stem cell biology
Q39201926The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma
Q36538487The implications of cancer stem cells for cancer therapy
Q36778291The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype
Q33685563The meaning of PIWI proteins in cancer development.
Q38018809The metastatic niche and stromal progression
Q36970312The molecular genetics of adrenocortical carcinoma
Q37636662The prognostic value of CSCs biomarker CD133 in NSCLC: a meta-analysis.
Q92528413The response of human mesenchymal stem cells to internal exposure to tritium β-rays
Q36629170The role of biodegradable engineered random polycaprolactone nanofiber scaffolds seeded with nestin-positive hair follicle stem cells for tissue engineering
Q35960211The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.
Q36196598The role of upregulated miRNAs and the identification of novel mRNA targets in prostatospheres
Q34785119The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells
Q28119042The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis
Q37615918Therapeutic implications of cellular and molecular biology of cancer stem cells in melanoma
Q38783106Toll-like receptors in hepatocellular carcinoma: potential novel targets for pharmacological intervention
Q38013989Tracing epithelial stem cells during development, homeostasis, and repair
Q39623731Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.
Q54360289Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype.
Q90040642Triple-Negative Breast Cancer: Current Understanding and Future Therapeutic Breakthrough Targeting Cancer Stemness
Q93102744Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment
Q38584340Tumor Microenvironment Versus Cancer Stem Cells in Cholangiocarcinoma: Synergistic Effects?
Q27318628Tumor cells positive and negative for the common cancer stem cell markers are capable of initiating tumor growth and generating both progenies
Q37950602Tumor promotion via injury- and death-induced inflammation
Q37774865Tumor-initiating and -propagating cells: cells that we would like to identify and control
Q33668830Tumorigenic WAP-T Mouse Mammary Carcinoma Cells: A Model for a Self-Reproducing Homeostatic Cancer Cell System
Q24629299Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling
Q39629096Use of multiple biomarkers for the localization and characterization of colon cancer stem cells by indirect immunocytochemistry
Q38784131Use of retinoic acid/aldehyde dehydrogenase pathway as potential targeted therapy against cancer stem cells
Q39627480Using ABCG2-molecule-expressing side population cells to identify cancer stem-like cells in a human ovarian cell line
Q26786070Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery
Q43093172What makes cancer stem cell markers different?
Q89573138When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance
Q29619273Wnt signalling and its impact on development and cancer
Q26745972Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication
Q38719437Zinc suppresses stem cell properties of lung cancer cells through protein kinase C-mediated β-catenin degradation
Q89748382miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells
Q47124421miR205 inhibits stem cell renewal in SUM159PT breast cancer cells
Q34038397microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts
Q37419204p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo.
Q33733341p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
Q36848635β -Elemene-Attenuated Tumor Angiogenesis by Targeting Notch-1 in Gastric Cancer Stem-Like Cells
Q30426105γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer

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