| scholarly article | Q13442814 |
| P2093 | author name string | Xianxin Hua | |
| Lewis A Chodosh | |||
| Zijie Feng | |||
| Dhruv K Pant | |||
| Austin T Thiel | |||
| P2860 | cites work | Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression | Q24297027 |
| CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis | Q24297763 | ||
| Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus | Q24313196 | ||
| The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression | Q24536084 | ||
| Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization | Q24603527 | ||
| Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia | Q24627314 | ||
| DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells | Q24655388 | ||
| Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein | Q27670797 | ||
| The same pocket in menin binds both MLL and JUND but has opposite effects on transcription | Q27677227 | ||
| Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin | Q27851546 | ||
| Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes | Q27851571 | ||
| hDOT1L links histone methylation to leukemogenesis | Q27935809 | ||
| Misguided transcriptional elongation causes mixed lineage leukemia | Q28471927 | ||
| MLL targets SET domain methyltransferase activity to Hox gene promoters | Q28609771 | ||
| EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas | Q28741454 | ||
| Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders | Q29614510 | ||
| MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. | Q33694927 | ||
| Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b | Q33889059 | ||
| The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. | Q33915185 | ||
| Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis | Q33987248 | ||
| Trithorax group proteins: switching genes on and keeping them active | Q34235226 | ||
| Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis | Q34319461 | ||
| Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas | Q34397318 | ||
| MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome | Q35083272 | ||
| DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis | Q35083276 | ||
| C/EBPalpha mutations in acute myeloid leukaemias | Q35762456 | ||
| Polycomb repressive complex 2 is required for MLL-AF9 leukemia | Q35882496 | ||
| MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. | Q35898171 | ||
| Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells | Q36726183 | ||
| Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development | Q36745250 | ||
| Dysregulation of the C/EBPalpha differentiation pathway in human cancer | Q37104787 | ||
| HOXA9 is required for survival in human MLL-rearranged acute leukemias | Q37129652 | ||
| Molecular mechanisms underlying deregulation of C/EBPalpha in acute myeloid leukemia | Q37737625 | ||
| Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins | Q37791830 | ||
| Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation | Q39614645 | ||
| C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene | Q39942216 | ||
| Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. | Q39953712 | ||
| Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. | Q40219637 | ||
| Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. | Q40252270 | ||
| The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. | Q42723875 | ||
| Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment | Q45007602 | ||
| Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. | Q45345900 | ||
| Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. | Q50594569 | ||
| Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. | Q50803016 | ||
| RUNX1/EVI1, which blocks myeloid differentiation, inhibits CCAAT-enhancer binding protein alpha function. | Q52582395 | ||
| Leukaemia stem cells and the evolution of cancer-stem-cell research. | Q53302987 | ||
| MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation. | Q53396186 | ||
| Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells. | Q54341375 | ||
| Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells | Q57615422 | ||
| Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny | Q77583284 | ||
| Interaction of MLL amino terminal sequences with menin is required for transformation | Q80726251 | ||
| Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells | Q83058254 | ||
| Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells | Q84225771 | ||
| P433 | issue | 6 | |
| P304 | page(s) | 918-927 | |
| P577 | publication date | 2013-01-24 | |
| P1433 | published in | Haematologica | Q5638209 |
| P1476 | title | The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia | |
| P478 | volume | 98 |
| Q30401808 | A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology |
| Q38194444 | Chromatin modifiers and the promise of epigenetic therapy in acute leukemia |
| Q38867022 | Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity |
| Q28539096 | DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy |
| Q93188540 | Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway |
| Q34375614 | EZH2 in normal and malignant hematopoiesis |
| Q38220397 | Epigenetic mechanisms of tumorigenicity manifesting in stem cells. |
| Q37683407 | Menin is required for optimal processing of the microRNA let-7a |
| Q38121288 | Menin: a scaffold protein that controls gene expression and cell signaling |
| Q38698037 | Semi-Quantitative Mass Spectrometry in AML Cells Identifies New Non-Genomic Targets of the EZH2 Methyltransferase. |
| Q57464007 | TRIB2 regulates the differentiation of MLL-TET1 transduced myeloid progenitor cells |
| Q36445523 | Targeting EZH2 and PRC2 dependence as novel anticancer therapy |
| Q43144356 | Trithorax and polycomb cooperation in MLL fusion acute leukemia |
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