| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/S10571-007-9163-Z |
| P698 | PubMed publication ID | 17657601 |
| P2093 | author name string | Han Yan | |
| Hai Yan Zhang | |||
| Xi Can Tang | |||
| P2860 | cites work | Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors | Q24294213 |
| X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement | Q27639524 | ||
| Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A | Q27734318 | ||
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics | Q27860914 | ||
| Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease | Q28236160 | ||
| The cholinesterases: from genes to proteins | Q28245653 | ||
| Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein | Q28247386 | ||
| Bcl-2 and Bax function independently to regulate cell death | Q28591263 | ||
| p53: puzzle and paradigm | Q29618407 | ||
| The mitochondrion in apoptosis: how Pandora's box opens | Q34286386 | ||
| Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? | Q34464761 | ||
| A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease | Q35166007 | ||
| Progress in Clinical, Pharmacological, Chemical and Structural Biological Studies of Huperzine A: A Drug of Traditional Chinese Medicine Origin for the Treatment of Alzheimers Disease | Q35551727 | ||
| Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells | Q36152115 | ||
| Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine | Q36346512 | ||
| Mitochondria as the target of the pro-apoptotic protein Bax. | Q36534322 | ||
| Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide | Q36578141 | ||
| Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils. | Q36885421 | ||
| Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion | Q77499756 | ||
| Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease | Q81078647 | ||
| Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha | Q40147094 | ||
| Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production | Q40383390 | ||
| Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells | Q40567243 | ||
| Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide | Q40790952 | ||
| Amyloid beta-protein and the genetics of Alzheimer's disease | Q41074945 | ||
| Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells | Q41361359 | ||
| Amyloid, the presenilins and Alzheimer's disease | Q41433661 | ||
| Hydrogen peroxide mediates amyloid beta protein toxicity | Q41460857 | ||
| Cleavage of amyloid beta peptide during constitutive processing of its precursor | Q41852594 | ||
| Apoptosis driven by IP(3)-linked mitochondrial calcium signals | Q42265765 | ||
| Cholinesterase inhibitors increase secretion of APPs in rat brain cortex | Q42276951 | ||
| The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling | Q42462551 | ||
| The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex | Q42556618 | ||
| Mechanism of inhibition of cholinesterases by huperzine A | Q43712194 | ||
| Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation | Q43831278 | ||
| Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice | Q43832603 | ||
| Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis. | Q43918118 | ||
| Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons | Q43975851 | ||
| Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons | Q44149266 | ||
| Amyloid beta peptide induces cytochrome C release from isolated mitochondria | Q44190608 | ||
| Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine | Q44225211 | ||
| beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies | Q44277892 | ||
| Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons | Q44385487 | ||
| Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells | Q44574259 | ||
| Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats | Q44890629 | ||
| Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons | Q45025269 | ||
| Transgenic murine cortical neurons expressing human Bcl-2 exhibit increased resistance to amyloid beta-peptide neurotoxicity | Q45859533 | ||
| Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells | Q46509880 | ||
| Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism | Q46956852 | ||
| ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease | Q47754186 | ||
| Colocalization of cholinesterases with beta amyloid protein in aged and Alzheimer's brains | Q48352514 | ||
| Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death | Q48390802 | ||
| Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. | Q48488443 | ||
| Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons | Q48495143 | ||
| Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons | Q48519431 | ||
| Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice | Q48546778 | ||
| Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats | Q48956623 | ||
| Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity | Q48983820 | ||
| Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. | Q49047282 | ||
| Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain | Q49055563 | ||
| Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies | Q49177167 | ||
| Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. | Q51978320 | ||
| Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat. | Q52130696 | ||
| Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. | Q52167583 | ||
| Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo. | Q53204206 | ||
| Acetylcholinesterase is a senile plaque component that promotes assembly of amyloid beta-peptide into Alzheimer's filaments. | Q53217445 | ||
| Molecular interactions of acetylcholinesterase with senile plaques. | Q53224790 | ||
| Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor. | Q53276945 | ||
| Protective effects of huperzine A on β-amyloid25–35 induced oxidative injury in rat pheochromocytoma cells | Q59215332 | ||
| Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury | Q73198099 | ||
| Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury | Q74218368 | ||
| Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells | Q74425256 | ||
| A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation | Q74427763 | ||
| P433 | issue | 2 | |
| P304 | page(s) | 173-183 | |
| P577 | publication date | 2007-07-27 | |
| P1433 | published in | Cellular and Molecular Neurobiology | Q2333197 |
| P1476 | title | Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase | |
| P478 | volume | 28 |
| Q89683589 | Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention |
| Q35481827 | Comparison of the efficacy of four cholinesterase inhibitors in combination with memantine for the treatment of Alzheimer's disease |
| Q34797526 | Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model |
| Q37735037 | Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration in rats. |
| Q37902135 | Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies |
| Q44285130 | Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD). |
| Q92463343 | Investigating the potential protective effects of natural product quercetin against imidacloprid-induced biochemical toxicity and DNA damage in adults rats |
| Q35646336 | Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons |
| Q92376331 | Natural Antioxidant Anthocyanins-A Hidden Therapeutic Candidate in Metabolic Disorders with Major Focus in Neurodegeneration |
| Q30393882 | New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics. |
| Q37508249 | Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup |
| Q45917550 | Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells. |
| Q51007192 | Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation. |
| Q42845252 | Site-Activated Chelators Derived from Anti-Parkinson Drug Rasagiline as a Potential Safer and More Effective Approach to the Treatment of Alzheimer’s Disease |
| Q40216897 | TSG attenuates LPC-induced endothelial cells inflammatory damage through notch signaling inhibition. |
| Q52643231 | Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice. |
| Q39946663 | The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats |
| Q81527536 | Therapeutic strategies for Alzheimer's disease |
| Q49672905 | Therapeutics of Neurotransmitters in Alzheimer's Disease |
| Q53324082 | Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model. |
| Q33757597 | Xanthoceraside ameliorates mitochondrial dysfunction contributing to the improvement of learning and memory impairment in mice with intracerebroventricular injection of aβ1-42. |
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