Redox imbalance in Parkinson's disease

scientific article published on 4 March 2008

Redox imbalance in Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.BBAGEN.2008.02.005
P932PMC publication ID2547405
P698PubMed publication ID18358848
P5875ResearchGate publication ID222241527

P2093author name stringJulie K Andersen
Shankar J Chinta
P2860cites workFree radicals and antioxidants in normal physiological functions and human diseaseQ21710698
Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometryQ24307861
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
Alpha-synuclein in Lewy bodiesQ27860680
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
Perspectives on MAO-B in aging and neurological disease: where do we go from here?Q28271492
Oxidative stress in neurodegeneration: cause or consequence?Q28275946
Complex III releases superoxide to both sides of the inner mitochondrial membraneQ28509539
Mice lacking alpha-synuclein are resistant to mitochondrial toxinsQ28511475
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's diseaseQ29547175
Oxidative stress in Parkinson's diseaseQ29618017
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adductQ31029246
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's diseaseQ32035138
Redox imbalanceQ33206786
Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's diseaseQ33220863
Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.Q33941736
Bioenergetic approaches for neuroprotection in Parkinson's diseaseQ33965184
Oxidation of LDL by myeloperoxidase and reactive nitrogen species: reaction pathways and antioxidant protectionQ33968464
Glutathione, oxidative stress and neurodegenerationQ33994473
Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative diseaseQ34015557
Pathoanatomy of Parkinson's diseaseQ34035667
Oxidative stress and protein aggregation during biological agingQ34348818
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.Q34394747
Oxidative stress and nitration in neurodegeneration: cause, effect, or association?Q35047296
Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's diseaseQ35728704
Does cellular iron dysregulation play a causative role in Parkinson's disease?Q35824954
Genetic clues to the pathogenesis of Parkinson's diseaseQ35844782
Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatmentQ35891905
Abnormalities of the electron transport chain in idiopathic Parkinson's diseaseQ69361952
Mitochondrial complex I deficiency in Parkinson's diseaseQ69370277
Factors determining the selectivity of protein tyrosine nitrationQ73141785
Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's diseaseQ79194214
???Q64767196
Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseasesQ35994672
Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxiaQ36129202
Molecular pathophysiology of Parkinson's diseaseQ36196507
Mitochondria take center stage in aging and neurodegenerationQ36264218
Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.Q36501983
Advances in the treatment of Parkinson's diseaseQ36720216
Monamine oxidase inhibitors: current and emerging agents for Parkinson diseaseQ36838868
Alterations in the distribution of glutathione in the substantia nigra in Parkinson's diseaseQ36895132
Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species.Q36899240
In vitro and in vivo neuroprotection by gamma-glutamylcysteine ethyl ester against MPTP: relevance to the role of glutathione in Parkinson's disease.Q40286709
Glutathione depletion in a midbrain-derived immortalized dopaminergic cell line results in limited tyrosine nitration of mitochondrial complex I subunits: implications for Parkinson's diseaseQ40401735
G209A mutant alpha synuclein expression specifically enhances dopamine induced oxidative damageQ40539190
Recent advances in pharmacological therapy of Parkinson's diseaseQ40707933
Induction of alpha-synuclein aggregation by intracellular nitrative insult.Q40776570
Presymptomatic detection of Parkinson's diseaseQ40808143
Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicityQ40844291
Oxidative stress and the pathogenesis of Parkinson's diseaseQ41262986
Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in miceQ41593145
Parkinson's disease: a disorder due to nigral glutathione deficiency?Q41628096
Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitroQ41646793
Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.Q41740537
Striatal dopamine deficiency in Parkinson's disease: role of agingQ41993839
Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophyQ42493792
Oxygen toxicity protecting enzymes in Parkinson's disease. Increase of superoxide dismutase-like activity in the substantia nigra and basal nucleusQ42515011
Reduced intravenous glutathione in the treatment of early Parkinson's diseaseQ42644977
Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposureQ43735123
Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegenerationQ43908040
Thioltransferase (glutaredoxin) mediates recovery of motor neurons from excitotoxic mitochondrial injury.Q44156159
Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapyQ44214157
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's diseaseQ44386905
Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modificationsQ44511146
Inhibition of brain mitochondrial respiration by dopamine and its metabolites: implications for Parkinson's disease and catecholamine-associated diseasesQ45138293
Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallateQ45227789
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlationsQ45302799
Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration.Q46377129
Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's diseaseQ48127846
Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's diseaseQ48140041
Apomorphine protects against MPTP-induced neurotoxicity in miceQ48144127
Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by alpha-lipoic acidQ48236376
Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthaseQ48253577
Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease.Q48302165
Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patientsQ48331251
Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age.Q48502457
Neural heme oxygenase-1 expression in idiopathic Parkinson's diseaseQ48503937
Understanding Parkinson's diseaseQ48825172
Depletion of brain glutathione results in a decrease of glutathione reductase activity; an enzyme susceptible to oxidative damage.Q48986485
Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.Q54071317
Oxidative Stress: Damage to Intact Cells and Organs [and Discussion]Q59151804
A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specific bindingQ64380309
Sequestration of iron by Lewy bodies in Parkinson's diseaseQ64771847
Localization of distinct monoamine oxidase a and monoamine oxidase b cell populations in human brainstemQ68456656
Deficiencies in complex I subunits of the respiratory chain in Parkinson's diseaseQ69356679
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
P304page(s)1362-1367
P577publication date2008-03-04
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleRedox imbalance in Parkinson's disease
P478volume1780