Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans

scientific article published on 16 April 2013

Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.1074/JBC.M113.467159
P932PMC publication ID3675610
P698PubMed publication ID23592791

P50authorRajendra PrasadQ89926093
P2093author name stringNeeraj Chauhan
Virander Singh Chauhan
Andrew M Lynn
Jyotsna Sharma
Indresh Kumar Maurya
Manpreet Kaur Rawal
Balaguru Ravikumar
Sobhan Sen
Chaitanya Kumar Thota
Sachin Dev Verma
P2860cites workMolecular aspects of fluconazole resistance development in Candida albicansQ43899356
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Characterization of Cdr1p, a major multidrug efflux protein of Candida albicans: purified protein is amenable to intrinsic fluorescence analysis.Q46942247
Transmembrane segment IV contributes a functionally important interface for oligomerization of the Class II G protein-coupled secretin receptor.Q51795077
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptidesQ56390180
Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candidaalbicans strainsQ61658940
Synergy, antagonism, and what the chequerboard puts between themQ73521098
Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-melittin hybrid peptidesQ77296547
PRALINETM: a strategy for improved multiple alignment of transmembrane proteinsQ80442814
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
Measurement of protein using bicinchoninic acidQ26778491
Transmembrane helix dimerization: beyond the search for sequence motifsQ26865109
Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol methodQ29547550
The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transportQ33560121
Influence of test conditions on antifungal time-kill curve results: proposal for standardized methodsQ33695704
Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.Q33721804
Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicansQ33826488
Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprintsQ33894971
Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transportersQ33983544
Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitorQ34334444
Analysis of protein interactions using fluorescence technologiesQ35568893
Functional characterization of Candida albicans ABC transporter Cdr1p.Q35697281
Serum differentially alters the antifungal properties of echinocandin drugsQ35840860
Homodimerization of amyloid precursor protein at the plasma membrane: a homoFRET study by time-resolved fluorescence anisotropy imagingQ36207429
Changing patterns and trends in systemic fungal infectionsQ36239992
Efflux-mediated antifungal drug resistance.Q37156645
Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungalsQ37274696
Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1pQ37337658
Yeast ATP-binding cassette transporters conferring multidrug resistanceQ38019037
Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: uncommon cysteine 193 of Walker A is critical for ATP hydrolysisQ38350658
The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicansQ38626885
Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains.Q39559578
Functional Similarities and Differences between Candida albicans Cdr1p and Cdr2p TransportersQ39746465
Transmembrane inhibitors of P-glycoprotein, an ABC transporterQ40417473
Drug efflux by a small multidrug resistance protein is inhibited by a transmembrane peptideQ41994971
Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potencyQ42067261
A key structural domain of the Candida albicans Mdr1 protein.Q43551296
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectCandida albicansQ310443
protein designQ410814
transmembrane proteinQ424204
multiple drug resistanceQ643839
P1104number of pages13
P304page(s)16775-16787
P577publication date2013-04-16
P1433published inJournal of Biological ChemistryQ867727
P1476titleRationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans
P478volume288

Reverse relations

cites work (P2860)
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Q42729942Efflux by small multidrug resistance proteins is inhibited by membrane-interactive helix-stapled peptides
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Q38833324Natural and synthetic peptides with antifungal activity
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