Proteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells.

scientific article published on 11 June 2013

Proteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BSR20130042
P932PMC publication ID3679596
P698PubMed publication ID23634903

P50authorStephen AssinderQ117631692
Des R. RichardsonQ37369291
P2093author name stringQihan Dong
Mohammad K Ghalayini
P2860cites workPhosphorylation of NDRG1 is temporally and spatially controlled during the cell cycle.Q39517194
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A novel splice variant of the beta-tropomyosin (TPM2) gene in prostate cancerQ39722976
Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta.Q39812521
Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinomaQ40168010
Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesisQ40266980
PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer.Q40497377
N-myc downregulated gene 1 is a phosphorylated protein in mast cellsQ40557937
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The differentiation-related gene 1, Drg1, is markedly upregulated by androgens in LNCaP prostatic adenocarcinoma cellsQ42475604
Protein glycosylation analysis by HILIC-LC-MS of Proteinase K-generated N- and O-glycopeptidesQ43133934
High expression of the Cap43 gene in infiltrating macrophages of human renal cell carcinomasQ43670925
Expression of tumor-associated trypsinogens (TAT-1 and TAT-2) in prostate cancerQ45224424
Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotypingQ46179386
Identification of a novel class in the alpha/beta hydrolase fold superfamily: the N-myc differentiation-related proteins.Q52043309
Differential expression of trypsinogen and tumor-associated trypsin inhibitor (TATI) in bladder cancer.Q52567580
Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture.Q53228752
The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms.Q53261745
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Hallmarks of Cancer: The Next GenerationQ22252312
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cellsQ24293029
Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene familyQ24293325
Expression of NDRG1, a differentiation-related gene, in human tissuesQ24318422
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3Q24528133
Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancersQ24794324
Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cellsQ28139030
Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cellsQ28139633
Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancerQ28144817
Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinasesQ28189259
Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genesQ28297991
A perspective on cancer cell metastasisQ28307891
Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2Q28348328
The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activationQ28365272
Activation of type IV procollagenases by human tumor-associated trypsin-2Q28619137
Phosphate-binding tag, a new tool to visualize phosphorylated proteinsQ29617792
The Drg-1 gene suppresses tumor metastasis in prostate cancer.Q31139046
Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression.Q34325547
The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer.Q34592812
The metastatic cascade in prostate cancerQ36675694
Frequent loss of cystatin E/M expression implicated in the progression of prostate cancerQ37294189
The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathwaysQ39371861
The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).Q39372971
Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancerQ39515084
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P577publication date2013-06-11
P1433published inBioscience ReportsQ2790714
P1476titleProteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells
P478volume33

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cites work (P2860)
Q64083660Cell and context-dependent sorting of neuropathy-associated protein NDRG1 - insights from canine tissues and primary Schwann cell cultures
Q36557412Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types
Q38165627Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.
Q41911962NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy
Q57467614Pseudotrypsin: A Little-Known Trypsin Proteoform
Q36326247Targeting cancer by binding iron: Dissecting cellular signaling pathways
Q36852491Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.
Q37683384The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.
Q35832242The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.
Q38436428Transcriptomic comparison of primary bovine horn core carcinoma culture and parental tissue at early stage

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