Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?

scientific article published on July 2007

Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1111/J.1582-4934.2007.00060.X
P932PMC publication ID3823251
P698PubMed publication ID17760834
P5875ResearchGate publication ID6079129

P50authorRalf WeiskirchenQ51753160
P2093author name stringAxel M Gressner
Jens Herrmann
P2860cites workEffect of six flavonoids on proliferation of hepatic stellate cells in vitroQ73810103
Proteome analysis of rat hepatic stellate cellsQ74071343
Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepaticQ74292004
CD133+ hepatic stellate cells are progenitor cellsQ79373868
[Inhibitory effect of interferon-beta on the activation of LX-2 and rHSC-99 hepatic stellate cells in culture]Q79985217
Leptin enhances alpha1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathwaysQ81237663
Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary cultureQ67743331
Liver fat storing cell proliferation is stimulated by epidermal growth factor/transforming growth factor alpha and inhibited by transforming growth factor betaQ69742276
Purified Rat Liver Fat-Storing Cells in Culture Divide and Contain CollagenQ70354518
Three-dimensional structure of extracellular matrix reversibly regulates morphology, proliferation and collagen metabolism of perisinusoidal stellate cells (vitamin A-storing cells)Q71807359
Human myofibroblastlike cells obtained by outgrowth are representative of the fibrogenic cells in the liverQ72016105
Heterogeneity of liver cells expressing procollagen types I and IV in vivoQ73478657
Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblastsQ73746119
Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblastsQ24795349
History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cellsQ28190388
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targetsQ28303698
PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell lineQ28577034
Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cellsQ28582231
Pro-fibrogenic potential of PDGF-D in liver fibrosisQ28583234
Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob miceQ31045022
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injuryQ33822590
Cooperation of liver cells in health and diseaseQ34103771
Roles of TGF-beta in hepatic fibrosisQ34565570
Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cellsQ34580695
Immortal activated human hepatic stellate cells generated by ectopic telomerase expressionQ38291132
Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via the transcription factor Ets-1 in human hepatic stellate cell lineQ38292286
An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro.Q38311930
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.Q38333252
Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotypeQ38357362
Leptin enhances the effect of transforming growth factor beta in increasing type I collagen formationQ38362368
Expression and upregulation of cathepsin S and other early molecules required for antigen presentation in activated hepatic stellate cells upon IFN-gamma treatmentQ40193409
Inhibitory effect of emodin on tissue inhibitor of metalloproteinases-1 (TIMP-1) expression in rat hepatic stellate cellsQ40198021
Effects of rhDecorin on TGF-beta1 induced human hepatic stellate cells LX-2 activationQ40215136
Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cellsQ40222219
PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cellsQ40225700
The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-beta in smooth muscle and hepatic stellate cellsQ40273781
Interleukin-1 beta up-regulates tissue inhibitor of matrix metalloproteinase-1 mRNA and phosphorylation of c-jun N-terminal kinase and p38 in hepatic stellate cellsQ40301210
A new immortalized rat cell line, hepatic stellate cell-PQ, exhibiting characteristics of hepatic stellate cell.Q40419126
Angiotensin II participates in hepatic inflammation and fibrosis through MCP-1 expressionQ40419536
The plasticity of p19 ARF null hepatic stellate cells and the dynamics of activation.Q40425998
Effect of IL-4 and IL-13 on collagen production in cultured LI90 human hepatic stellate cellsQ40444779
Effect of prostaglandin E2 and prostaglandin I2 on PDGF-induced proliferation of LI90, a human hepatic stellate cell lineQ40513357
Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cellsQ40610380
Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: respective roles of the JAK/STAT and JAK-mediated H2O2-dependant MAPK pathwaysQ40615430
Reverse transformation of hepatic myofibroblast-like cells by TGFbeta1/LAP.Q40615930
Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell lineQ40637668
Establishment of an immortalized human hepatic stellate cell line to develop antifibrotic therapiesQ40638123
Treatment of the rat hepatic stellate cell line, PAV-1, by retinol and palmitic acid leads to a convenient model to study retinoids metabolism.Q40681219
PAV-1, a new rat hepatic stellate cell line converts retinol into retinoic acid, a process altered by ethanol.Q40732567
Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injuryQ40757687
Induction of the lipocyte phenotype in murine hepatic stellate cells: reorganisation of the actin cytoskeleton.Q40772003
Intermediate filaments modulation in an in vitro model of the hepatic stellate cell activation or conversion into the lipocyte phenotypeQ40783124
Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrateQ60537805
Inhibitory effects of antisense oligonucleotides on the expression of procollagen type III gene in mouse hepatic stellate cells transformed by simian virus 40.Q40836363
Tumor necrosis factor alpha down-regulates expression of the alpha1(I) collagen gene in rat hepatic stellate cells through a p20C/EBPbeta- and C/EBPdelta-dependent mechanism.Q40882326
Inhibition of hyaluronan synthesis by vesnarinone in cultured human myofibroblastsQ40902542
Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potentialQ40921225
Induction of calponin-h1 by transforming growth factor-beta1 in cultured human ito cells, LI90.Q41035301
Cell growth and differentiation of a novel mouse Ito (fat-storing) cell line transformed by a temperature-sensitive mutant of simian virus 40.Q41097749
Characterization of a new human liver myofibroblast cell line: transcriptional regulation of plasminogen activator inhibitor type I by transforming growth factor beta 1.Q41101457
Effects of retinol on proliferation, cell adherence and extracellular matrix synthesis in a liver myofibroblast or lipocyte cell line (GRX).Q41155909
Establishment of a new human cell line, LI90, exhibiting characteristics of hepatic Ito (fat-storing) cells.Q41342641
Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6Q41654901
Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in miceQ42450667
Regulation of the α2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liverQ42804307
Urokinase plasminogen activator stimulates function of active forms of stromelysin and gelatinases (MMP-2 and MMP-9) in cirrhotic tissueQ42805229
Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43.Q42809891
Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells.Q44445221
Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers.Q44481012
Aldosterone stimulating PDGF-B expression in HSC via activation of EGR-1Q46644086
Isolation and culture of hepatic stellate cellsQ46666110
Angiotensin II and aldosterone stimulate alpha1-(I) procollagen mRNA expression in hepatic stellate cells via activation of ERK1/2 and AP-1Q46777233
Immunosuppressant FK506 inhibits matrix metalloproteinase-9 induction in TNF-alpha-stimulated human hepatic stellate cellsQ46816197
Smad3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-beta1 in cultured rat hepatic stellate cellsQ46845532
Zonal and regional differences identified from precision mapping of vitamin A-storing lipid droplets of the hepatic stellate cells in pig liver: a novel concept of addressing the intralobular area of heterogeneityQ48599442
Purification of rat hepatic stellate cells by side scatter-activated cell sorting.Q50525615
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations.Q50785680
Establishment of a continuous cell line from fibrotic schistosomal granulomas in mice livers.Q52830872
Effect of ribozyme against transforming growth factorbeta1 on biological character of activated HSCs.Q53665264
[Effects of gamma-interferon on gene expression of collagen I, III and on the tissue inhibitor of metalloprotenase 1 in HSC-T6 cells].Q53959492
P4510describes a project that usesHSC 180Q54896369
HSC-PQQ54896417
HSC-T6Q54896418
hTERT-HSCQ54896630
LX-1Q54903296
LX-2Q54903298
M1-4HSCQ54903439
MFBY2Q54905374
NFSCQ54930451
PAV-1Q54938333
SV68c-ISQ54970980
T-HSC/Cl-6Q54971363
A640-ISQ54607176
A7Q54607181
BSCQ54798389
BSC-C10Q54798390
CFSCQ54811453
GREF-XQ54871686
GRXQ54871708
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcell lineQ21014462
hepatocyteQ827450
cell biologyQ7141
cellQ7868
biomedical investigative techniqueQ66648976
P304page(s)704-722
P577publication date2007-07-01
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titleImmortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
P478volume11

Reverse relations

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Q54798389BSC
Q54798390BSC-C10
Q54811453CFSC
Q54811454CFSC-2G
Q54811455CFSC-3H
Q54811456CFSC-5H
Q54811457CFSC-8B
Q54871686GREF-X
Q54871708GRX
Q54896369HSC 180
Q54896417HSC-PQ
Q54896418HSC-T6
Q54903296LX-1
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Q54903439M1-4HSC
Q54905374MFBY2
Q54930451NFSC
Q54938333PAV-1
Q54970980SV68c-IS
Q54971363T-HSC/Cl-6
Q54896630hTERT-HSC

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Q39676905Co-culture based blood-brain barrier in vitro model, a tissue engineering approach using immortalized cell lines for drug transport study
Q38718726Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma
Q82234749Elevated free fatty acids and impaired adiponectin bioactivity contribute to reduced SOD2 protein in monocytes of type 2 diabetes patients
Q82299271Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis
Q37363773Experimental liver fibrosis research: update on animal models, legal issues and translational aspects
Q36442525Experimental models of liver fibrosis
Q38699438Fructose-1,6-bisphosphate reverts iron-induced phenotype of hepatic stellate cells by chelating ferrous ions.
Q33608724F‑actin cytoskeleton reorganization is associated with hepatic stellate cell activation
Q35014533Genetic characteristics of the human hepatic stellate cell line LX-2.
Q36065064HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells
Q54968056Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis.
Q45366886Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2.
Q34372661Hepatocyte apoptotic bodies encasing nonstructural HCV proteins amplify hepatic stellate cell activation: implications for chronic hepatitis C.
Q42322952Human antigen R contributes to hepatic stellate cell activation and liver fibrosis
Q45931088Human hepatic stellate cell isolation and characterization.
Q39471795Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells.
Q38816350Inhibition of IRF3 expression reduces TGF-β1-induced proliferation of hepatic stellate cells
Q45871148Isolation and Culture of Primary Murine Hepatic Stellate Cells
Q36202215Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cells
Q39837032Lycopene isomerisation and storage in an in vitro model of murine hepatic stellate cells
Q37134618Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation
Q34598380Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line
Q50876050Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration.
Q28728604Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver
Q91689967SCARNA10, a nuclear-retained long non-coding RNA, promotes liver fibrosis and serves as a potential biomarker
Q34979996SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-β1 and PDGF
Q37705049Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling
Q64298451Therapeutic effect of DC. extracts on activated hepatic stellate cells
Q37234131Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation
Q33443530Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different species
Q64230111and its monomers alleviate liver fibrosis both in mice and LX2 cells by blocking TβR1-Smad2/3 and TNF-α-NF-κB pathways
Q37111117ω-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation.

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