review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Mikko I Mäyränpää | Q55762320 |
P2093 | author name string | Petri T Kovanen | |
Ken A Lindstedt | |||
P2860 | cites work | Human beta-tryptase is a ring-like tetramer with active sites facing a central pore | Q27748987 |
A novel model of occlusive thrombus formation in mice | Q28211808 | ||
Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin | Q28217128 | ||
Mast cells | Q28253429 | ||
Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology | Q28300693 | ||
Increase in atherosclerosis and adventitial mast cells in cocaine abusers: an alternative mechanism of cocaine-associated coronary vasospasm and thrombosis | Q28327883 | ||
Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase | Q28362035 | ||
Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin | Q41591021 | ||
Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion | Q42066527 | ||
Human endothelial cells regulate survival and proliferation of human mast cells | Q42126156 | ||
Demonstration of the origin of human mast cells from CD34+ bone marrow progenitor cells | Q42829029 | ||
The heterogeneity of mast cell tryptase from human lung and skin | Q38357286 | ||
Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration | Q39735956 | ||
Clinical use of TNF revisited: improving penetration of anti-cancer agents by increasing vascular permeability | Q39735980 | ||
Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice | Q39802780 | ||
Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: role in cell migration | Q40247795 | ||
A simple method of plaque rupture induction in apolipoprotein E-deficient mice | Q40337915 | ||
Mast cell activation by lipoproteins. | Q40383558 | ||
Exposure to tobacco-derived materials induces overproduction of secreted proteinases in mast cells | Q40439328 | ||
Coronary artery spasm. Multiple causes and multiple roles in heart disease | Q40520058 | ||
Histamine selectively interrupts VE-cadherin adhesion independently of capacitive calcium entry | Q40541215 | ||
IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells | Q40624585 | ||
Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases. | Q40669694 | ||
Heparin antagonists are potent inhibitors of mast cell tryptase | Q40799836 | ||
Heparin inhibits thrombin-induced mitogen-activated protein kinase signaling in arterial smooth muscle cells | Q40863061 | ||
Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation | Q40908061 | ||
Leukocyte-endothelial cell interactions evoked by mast cells | Q40925059 | ||
Role of leukotrienes in coronary artery surgery. | Q40953009 | ||
Expression of stem cell factor in human aortic endothelial and smooth muscle cells | Q41120244 | ||
Mast cells in human fatty streaks and atheromas: implications for intimal lipid accumulation. | Q41235021 | ||
Macrophages and atherosclerotic plaque stability. | Q41235093 | ||
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibition in a rat mast cell line. Impairment of tyrosine kinase-dependent signal transduction and the subsequent degranulation response. | Q41541987 | ||
Evidence for a role of mast cells in the evolution to congestive heart failure | Q42944600 | ||
Mast cell chymase induces apoptosis of vascular smooth muscle cells. | Q43576445 | ||
Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase | Q43626582 | ||
Human mast cells release metalloproteinase-9 on contact with activated T cells: juxtacrine regulation by TNF-alpha | Q43743353 | ||
Granule changes of human skin mast cells characteristic of piecemeal degranulation and associated with recovery during wound healing in situ. | Q43810457 | ||
Mast cell chymase inhibits smooth muscle cell growth and collagen expression in vitro: transforming growth factor-beta1-dependent and -independent effects | Q43822391 | ||
Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study | Q43904259 | ||
Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice | Q43909351 | ||
Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice | Q43989979 | ||
Chymase inhibition suppresses high-cholesterol diet-induced lipid accumulation in the hamster aorta | Q44100854 | ||
Lymphatic vessels in colorectal cancer and their relation with inflammatory infiltrate | Q44289183 | ||
Mast cell-mediated apoptosis of endothelial cells in vitro: a paracrine mechanism involving TNF-alpha-mediated down-regulation of bcl-2 expression | Q44323772 | ||
Blood histamine is associated with coronary artery disease, cardiac events and severity of inflammation and atherosclerosis. | Q44336171 | ||
IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor | Q44368615 | ||
Intraplaque hemorrhage and progression of coronary atheroma | Q44688413 | ||
Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components | Q45067683 | ||
Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique | Q45171075 | ||
The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease | Q45286964 | ||
Carotid plaque mast cells associate with atherogenic serum lipids, high grade carotid stenosis and symptomatic carotid artery disease. Results from the helsinki carotid endarterectomy study | Q46388176 | ||
Plaque rupture after short periods of fat feeding in the apolipoprotein E-knockout mouse: model characterization and effects of pravastatin treatment | Q46395823 | ||
Histamine induces tissue factor expression: implications for acute coronary syndromes | Q46595090 | ||
Endothelial cell activation by mast cell mediators | Q46658624 | ||
Degradation of Airway Neuropeptides by Human Lung Tryptase | Q46727039 | ||
Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves. | Q46886153 | ||
Effects of various statins on cytokine-dependent growth and IgE-dependent release of histamine in human mast cells | Q46911182 | ||
Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts | Q47903090 | ||
Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles | Q48251836 | ||
New aspects in thrombosis research: possible role of mast cells as profibrinolytic and antithrombotic cells. | Q50233501 | ||
Inhibition of human mast cell growth and differentiation by interferon gamma-1b. | Q50525161 | ||
Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/Fc epsilon RI- cell population | Q50768583 | ||
Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas. | Q50772419 | ||
Mast cell distribution, activation, and phenotype in atherosclerotic lesions of human carotid arteries. | Q52194636 | ||
Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion. | Q52574343 | ||
Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation. | Q53958148 | ||
Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. | Q54319446 | ||
Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration | Q57951001 | ||
Critical protective role of mast cells in a model of acute septic peritonitis | Q59072203 | ||
Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α | Q59092114 | ||
Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries | Q62056233 | ||
Perivascular Mast Cells Promote Atherogenesis and Induce Plaque Destabilization in Apolipoprotein E–Deficient Mice | Q63258329 | ||
Effect of broad-spectrum matrix metalloproteinase inhibition on atherosclerotic plaque stability | Q63915768 | ||
Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell. | Q64947865 | ||
Regulation of smooth muscle cell function by heparin | Q68113176 | ||
Increased adventitial mast cells in a patient with coronary spasm | Q68943619 | ||
Intermittent coronary occlusion in acute myocardial infarction. Value of combined thrombolytic and vasodilator therapy | Q69406329 | ||
The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover | Q28592458 | ||
Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions | Q28645945 | ||
Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis | Q30445142 | ||
Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data | Q31096289 | ||
TNF regulates leukocyte-endothelial cell interactions and microvascular dysfunction during immune complex-mediated inflammation. | Q31141979 | ||
Mast cell tissue inhibitor of metalloproteinase-1 is cleaved and inactivated extracellularly by alpha-chymase | Q31839582 | ||
Chymase bound to heparin is resistant to its natural inhibitors and capable of proteolyzing high density lipoproteins in aortic intimal fluid | Q32063001 | ||
A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. | Q33210291 | ||
TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility | Q33239894 | ||
The presence of membrane-bound stem cell factor on highly immature nonmetachromatic mast cells in the peripheral blood of a patient with aggressive systemic mastocytosis | Q33497337 | ||
Mast cells as sentinels of innate immunity | Q33536530 | ||
Mast cells enhance T cell activation: Importance of mast cell-derived TNF. | Q33772139 | ||
Mast cell-committed progenitors | Q33914165 | ||
Mast cell modulation of immune responses to bacteria | Q33941678 | ||
Vascular inflammation and the renin-angiotensin system | Q33960784 | ||
Therapeutic potential of matrix metalloproteinase inhibitors in atherosclerosis | Q34074837 | ||
Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries | Q34098485 | ||
Mast cells: a cellular link between autoantibodies and inflammatory arthritis | Q34148153 | ||
Local angiotensin II-generating system in vascular tissues: the roles of chymase | Q34284663 | ||
Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase. | Q34329991 | ||
Human beta-tryptase: detection and characterization of the active monomer and prevention of tetramer reconstitution by protease inhibitors | Q34341240 | ||
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. | Q34367607 | ||
Chymase-dependent angiotensin II forming systems in humans | Q34387779 | ||
The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus | Q34407347 | ||
Interactions of mast cell tryptase with thrombin receptors and PAR-2. | Q34415372 | ||
Effect of recombinant human IL-4 on tryptase, chymase, and Fc epsilon receptor type I expression in recombinant human stem cell factor-dependent fetal liver-derived human mast cells. | Q34439580 | ||
Eicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathobiologic implications | Q34443919 | ||
Cytokines in atherosclerosis: pathogenic and regulatory pathways | Q34511711 | ||
Mast cells can enhance resistance to snake and honeybee venoms | Q34551900 | ||
Mast cells are essential intermediaries in regulatory T-cell tolerance | Q34559099 | ||
Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation | Q34579741 | ||
Animal models of spontaneous plaque rupture: the holy grail of experimental atherosclerosis research. | Q34586858 | ||
Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell | Q34603405 | ||
Mast cells and angiogenesis | Q34698798 | ||
Clinical pharmacology of H1-antihistamines | Q34734428 | ||
Heterotypic adhesion-induced mast cell activation: biologic relevance in the inflammatory context | Q34825548 | ||
Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion | Q35017864 | ||
The mast cell: an antenna of the microenvironment that directs the immune response | Q35630524 | ||
Vascular chymase: pathophysiological role and therapeutic potential of inhibition | Q35676125 | ||
Fcgamma receptors on mast cells: activatory and inhibitory regulation of mediator release | Q35689326 | ||
Effector cells of anaphylaxis: mast cells and basophils | Q35693182 | ||
The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice | Q35792034 | ||
Lysosomal cysteine proteases in atherosclerosis | Q35792643 | ||
Proteolysis of the pericellular matrix: a novel element determining cell survival and death in the pathogenesis of plaque erosion and rupture. | Q35801993 | ||
Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice | Q35804444 | ||
Mast cells in vulnerable coronary plaques: potential mechanisms linking mast cell activation to plaque erosion and rupture | Q35884657 | ||
Mast-cell responses to pathogens. | Q35906088 | ||
Physiology and pathophysiology of proteinase-activated receptors (PARs): role of tryptase/PAR-2 in vascular endothelial barrier function | Q36012128 | ||
New aspects in thrombotic research: complement induced switch in mast cells from a profibrinolytic to a prothrombotic phenotype | Q36030536 | ||
Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue. | Q36229692 | ||
Role of angiogenesis in cardiovascular disease: a critical appraisal. | Q36261464 | ||
Phosphodiesterase inhibitors. | Q36364429 | ||
Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo | Q36366794 | ||
Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. | Q36368565 | ||
T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro | Q36375111 | ||
Efficiency of recombinant human TNF in human cancer therapy | Q36427212 | ||
Biology of mast cell tryptase. An inflammatory mediator | Q36460904 | ||
The immune response in atherosclerosis: a double-edged sword | Q36508676 | ||
In vitro and in vivo expression of interstitial collagenase/MMP-1 by human mast cells | Q36511375 | ||
The role of leukotrienes in the pathophysiology of inflammatory disorders: is there a case for revisiting leukotrienes as therapeutic targets? | Q36533935 | ||
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models | Q36534366 | ||
T cells in atherogenesis: for better or for worse? | Q36594608 | ||
The effect of certain sporulation conditions on the thermal death rate of Bacillus coagulans var. thermoacidurans | Q36623716 | ||
Targeting kit activation: a potential therapeutic approach in the treatment of allergic inflammation | Q36757680 | ||
Selective growth of human mast cells induced by Steel factor, IL-6, and prostaglandin E2 from cord blood mononuclear cells | Q36805113 | ||
Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice | Q37379247 | ||
Mast cells: a unique source of renin | Q37535136 | ||
Inhibition of exercise-induced asthma by an orally absorbed mast cell stabilizer (M & B 22,948) | Q70261775 | ||
Susceptibility of soluble and matrix fibronectins to degradation by tissue proteinases, mast cell chymase and cathepsin G | Q70537730 | ||
Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: a mechanism for coronary spasm | Q71282987 | ||
Mast cells accompany microvessels in human coronary atheromas: implications for intimal neovascularization and hemorrhage | Q71473176 | ||
Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells | Q71622380 | ||
Mast cells in rupture-prone areas of human coronary atheromas produce and store TNF-alpha | Q71828313 | ||
The endothelium during cuff-induced neointima formation in the rabbit carotid artery | Q72609516 | ||
Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture | Q72711418 | ||
Heparin protects cathepsin G against inhibition by protein proteinase inhibitors | Q72809150 | ||
Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13) | Q73023303 | ||
Histamine induces tyrosine phosphorylation of endothelial cell-to-cell adherens junctions | Q73083008 | ||
Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation | Q73134578 | ||
Association of coronary plaque rupture and atherosclerotic inflammation | Q73158920 | ||
Mast cells and susceptibility to experimental atherosclerosis | Q73167379 | ||
Human mast cells modulate proliferation and cytokine production by CD8+ T lymphocytes | Q73295740 | ||
Mast cells in human atherosclerosis | Q73513175 | ||
Adventitial mast cells connect with sensory nerve fibers in atherosclerotic coronary arteries | Q73660477 | ||
Endotoxin and mast cell granule proteases synergistically activate human coronary artery endothelial cells to generate interleukin-6 and interleukin-8 | Q73775218 | ||
Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow | Q73832982 | ||
Mast cell activation in arthritis: detection of alpha- and beta-tryptase, histamine and eosinophil cationic protein in synovial fluid | Q73953214 | ||
Interleukin-4 promotes the development of tryptase and chymase double-positive human mast cells accompanied by cell maturation | Q73981951 | ||
Chymase-dependent angiotensin II formation in human vascular tissue | Q74045429 | ||
Native macromolecular heparin proteoglycans exocytosed from stimulated rat serosal mast cells strongly inhibit platelet-collagen interactions | Q74070996 | ||
Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis | Q74082195 | ||
Nerve growth factor prevents apoptosis of cord blood-derived human cultured mast cells synergistically with stem cell factor | Q74129524 | ||
Evidence for complement activation in ruptured coronary plaques in acute myocardial infarction | Q74571114 | ||
Induction of atherosclerosis in Brown Norway rats by immunization with ovalbumin | Q77229886 | ||
HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages | Q77544869 | ||
Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques | Q77544889 | ||
Clinical correlates of the presence of the Asp816Val c-kit mutation in the peripheral blood mononuclear cells of patients with mastocytosis | Q77596992 | ||
Regulation of the activity of secreted human lung mast cell tryptase by mast cell proteoglycans | Q77631624 | ||
Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions | Q77869935 | ||
Heparin proteoglycans released from rat serosal mast cells inhibit proliferation of rat aortic smooth muscle cells in culture | Q77896725 | ||
Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery | Q77905030 | ||
Interleukin-6 directly modulates stem cell factor-dependent development of human mast cells derived from CD34(+) cord blood cells | Q77974774 | ||
Peri-arterial mast cells in coronary atheroma and thrombosis | Q78335263 | ||
Neutrophil infiltration of culprit lesions in acute coronary syndromes | Q78598074 | ||
Mast cells modulate the inflammatory but not the proliferative response in healing wounds | Q78968028 | ||
Recent insights into the role of prostanoids in atherosclerotic vascular disease | Q79315968 | ||
Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease | Q79374759 | ||
Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene | Q79397762 | ||
Mast cells in neovascularized human coronary plaques store and secrete basic fibroblast growth factor, a potent angiogenic mediator | Q80396372 | ||
Genentech discloses safety concerns over Avastin | Q80833883 | ||
Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF | Q82459138 | ||
Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction | Q93864816 | ||
Mast cells and their relationship to endothelial surfaces | Q95790926 | ||
P433 | issue | 4 | |
P921 | main subject | cell | Q7868 |
atherosclerosis | Q12252367 | ||
mast cell | Q191989 | ||
hemic and immune systems | Q70202933 | ||
P304 | page(s) | 739-758 | |
P577 | publication date | 2007-07-01 | |
P1433 | published in | Journal of Cellular and Molecular Medicine | Q1524063 |
P1476 | title | Mast cells in vulnerable atherosclerotic plaques--a view to a kill | |
P478 | volume | 11 |
Q35866675 | "Gum bug, leave my heart alone!"--epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis. |
Q64276506 | Acute and Chronic Effects of Cocaine on Cardiovascular Health |
Q28245234 | Cathepsin G activity lowers plasma LDL and reduces atherosclerosis |
Q58843476 | Comparison between the collagen intensity and mast cell density in the lingual muscles and myocardium of autopsied chronic chagasic and nonchagasic patients |
Q36223006 | Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation |
Q37277837 | Elevated Adiponectin Levels Suppress Perivascular and Aortic Inflammation and Prevent AngII-induced Advanced Abdominal Aortic Aneurysms |
Q37159140 | Endogenous suppression of mast cell development and survival by IL-4 and IL-10. |
Q35889058 | Functional alterations of myeloid cell subsets in hyperlipidaemia: relevance for atherosclerosis |
Q33667252 | Glucagon effects on 3H-histamine uptake by the isolated guinea-pig heart during anaphylaxis. |
Q35043956 | Histamine blood concentration in ischemic heart disease patients |
Q37325024 | Immune and inflammatory mechanisms of atherosclerosis (*) |
Q37821238 | Ischemia/reperfusion injury: The role of immune cells |
Q37578873 | Mast cell chymase and tryptase as targets for cardiovascular and metabolic diseases |
Q37133226 | Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure |
Q37441281 | Mast cells in atherogenesis: actions and reactions |
Q35376176 | Mountain cedar pollen induces IgE-independent mast cell degranulation, IL-4 production, and intracellular reactive oxygen species generation |
Q47148282 | New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis. |
Q34591182 | Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells. |
Q41541775 | Serum tryptase detected during acute coronary syndrome is significantly related to the development of major adverse cardiovascular events after 2 years. |
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