Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2

scientific article published on 02 June 2015

Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JACS.5B01607
P932PMC publication ID4878121
P698PubMed publication ID26035228
P5875ResearchGate publication ID277599501

P2093author name stringCatherine Leimkuhler Grimes
Ching-Wen Hou
Vishnu Mohanan
Amy K Schaefer
James E Melnyk
P2860cites workNod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detectionQ24292675
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn diseaseQ24296753
Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognitionQ24306842
Quantification of protein half-lives in the budding yeast proteomeQ24674092
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's diseaseQ28201834
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune systemQ33268810
Why are the hydroxy groups of partially protected N-acetylglucosamine derivatives such poor glycosyl acceptors, and what can be done about it? A comparative study of the reactivity of N-acetyl-, N-phthalimido-, and 2-azido-2-deoxy-glucosamine derivaQ33423429
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycinQ33699590
An efficient, inexpensive, and shelf-stable diazotransfer reagent: imidazole-1-sulfonyl azide hydrochlorideQ34005894
Deception point: peptidoglycan modification as a means of immune evasionQ35612173
Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycansQ35736952
Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.Q36080388
Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall componentsQ36407841
Debugging how bacteria manipulate the immune response.Q36739044
Structural variation in the glycan strands of bacterial peptidoglycanQ37028275
Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptideQ37292790
Nod2 is required for the regulation of commensal microbiota in the intestineQ37354181
NOD1 and NOD2 Signaling in Infection and Inflammation.Q38060719
The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragmentQ39303552
Synthesis of biologically active biotinylated muramyl dipeptidesQ39658629
Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cellsQ40170522
Dynamic stabilization of nuclear receptor ligand binding domains by hormone or corepressor bindingQ40855596
Synthesis and immunoadjuvant activities of muramoyl-L-alanyl-D-isoglutamine and some carbohydrate analogsQ42271581
Identification of a synthetic muramyl peptide derivative with enhanced Nod2 stimulatory capacityQ42277949
Design and synthesis of novel cell wall inhibitors of Mycobacterium tuberculosis GlmM and GlmU.Q42731628
Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycanQ45136861
Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureusQ45231397
Synthesis of a biologically active fluorescent muramyl dipeptide congenerQ46360933
A robust synthesis of N-glycolyl muramyl dipeptide via azidonitration/reduction.Q51027831
The importance of ligands for G protein-coupled receptor stability.Q53634312
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivativesQ53768109
Chemical modification of the C-6 substituent in the carbohydrate moiety of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP), and the immunoadjuvant activity.Q53919364
A safe and facile route to imidazole-1-sulfonyl azide as a diazotransfer reagentQ85653333
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)6987-6990
P577publication date2015-06-02
P1433published inJournal of the American Chemical SocietyQ898902
P1476titlePeptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2
P478volume137

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cites work (P2860)
Q58780924Bacterial Strategies to Preserve Cell Wall Integrity Against Environmental Threats
Q47973286Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70.
Q42047981From bacterial killing to immune modulation: Recent insights into the functions of lysozyme
Q48124216Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2.
Q33622000Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications
Q54236491Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2.
Q46269946NOD2 and bacterial recognition as therapeutic targets for Crohn's disease.
Q38741155Neisseria gonorrhoeae Lytic Transglycosylases LtgA and LtgD Reduce Host Innate Immune Signaling through TLR2 and NOD2.
Q52732929Peptidoglycan recognition by the innate immune system.
Q38795438The effect of NOD2 on the microbiota in Crohn's disease