Fluoroacetate and fluorocitrate: mechanism of action

scientific article published on September 1991

Fluoroacetate and fluorocitrate: mechanism of action is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/BF00965850
P698PubMed publication ID1784332

P2093author name stringD D Clarke
P2860cites workEnzymatic defluorination and metabolism of fluoroacetate, fluoroacetamide, fluoroethanol, and (-)-erythro-fluorocitrate in rats and mice examined by 19F and 13C NMRQ28341753
Enzymatic formation of glutathione-citryl thioester by a mitochondrial system and its inhibition by (-)erythrofluorocitrateQ35061025
Fluorinated substrate analogs: routes of metabolism and selective toxicity.Q40159305
FLUOROACETATE AND THE METABOLISM OF AMMONIA IN BRAINQ41904518
Isolation of 2-fluorocitrate produced by in vivo dealkylation of 29-fluorostigmasterol in an insectQ42076142
Tricarboxylic acid-cycle metabolism in brain. Effect of fluoroacetate and fluorocitrate on the labelling of glutamate aspartate, glutamine and γ-amino butyrateQ42126596
Some Metabolic Aspects of Fluoroacetate Especially Related to FluorocitrateQ46256402
Acetate and fluoroacetate as possible markers for glial metabolism in vivoQ48310034
The effect of injections of fluorocitrate into the brains of rats.Q51191209
Note upon the behaviour of rat brain tissue treated with fluoroacetate in vitroQ51225360
Fluorocitrate inhibition of aconitase. Reversibility of the inactivationQ53771855
Studies with specific enzyme inhibitors. XII. Resolution of DL-erythro-fluorocitric acid into optically active isomers.Q54716064
Triethyl α-FluoroaconitateQ58954350
Absolute configuration of the isomer of fluorocitrate that inhibits aconitase.Q64937342
Regional distribution of astrocytes with intense immunoreactivity for glutamate dehydrogenase in rat brain: implications for neuron-glia interactions in glutamate transmissionQ68172753
Fluorofumarate--a substrate for fumarate hydrataseQ68574032
Seizures induced by fluoroacetic acid and fluorocitric acid may involve chelation of divalent cations in the spinal cordQ68841778
An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: the use of fluorocitrateQ68965665
Stereochemical studies on the hydration of monofluorofumarate and 2,3-difluorofumarate by fumaraseQ70394016
P433issue9
P304page(s)1055-1058
P577publication date1991-09-01
P1433published inNeurochemical ResearchQ15716728
P1476titleFluoroacetate and fluorocitrate: mechanism of action
P478volume16

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cites work (P2860)
Q35003093Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain
Q71513399Amino acid-induced [Ca2+]i oscillations in single mouse pancreatic islets of Langerhans
Q51155857Assessment of [(18)F]-fluoroacetate PET/CT as a tumor-imaging modality: preclinical study in healthy volunteers and clinical evaluation in patients with liver tumor.
Q42025298Astrocyte-mediated distributed plasticity at hypothalamic glutamate synapses
Q41829135Astrocytes Modulate Distribution and Neuronal Signaling of Leptin in the Hypothalamus of Obese A vy Mice
Q30921812Brain glycogen re-awakened
Q98578557Ca2+ -dependent release of ATP from astrocytes affects herpes simplex virus Type 1 infection of neurons
Q36438603Catalytic control of enzymatic fluorine specificity
Q42442938Changes in extracellular nitrite and nitrate levels after inhibition of glial metabolism with fluorocitrate
Q39069512Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS.
Q43942162Citrate, beneficial or deleterious in the CNS?
Q64355537Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential
Q37459046Direct measurement of oxidative metabolism in the living brain by microdialysis: a review
Q90170076Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation
Q49914157Entropy drives selective fluorine recognition in the fluoroacetyl-CoA thioesterase from Streptomyces cattleya.
Q51706586Estimation of reliability of predictions and model applicability domain evaluation in the analysis of acute toxicity (LD50).
Q48516422Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain
Q46113351Fluorothreonyl-tRNA deacylase prevents mistranslation in the organofluorine producer Streptomyces cattleya
Q35194230Functional P2X7 receptors at cultured hippocampal astrocytes but not neurons
Q48576613Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus.
Q41926844Glial-derived adenosine modulates spinal motor networks in mice.
Q48343398Gliotoxin-induced suppression of ocular dominance plasticity in kitten visual cortex
Q48094337Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks.
Q37071822Hindbrain cytoglucopenia-induced increases in systemic blood glucose levels by 2-deoxyglucose depend on intact astrocytes and adenosine release
Q36520153Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with ¹⁸F-FAHA.
Q38512396Inhibition of mitochondrial function in astrocytes: implications for neuroprotection.
Q41351296K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study
Q44071540Kinetics and organotropy of some polyfluorinated dibenzo-p-dioxins and dibenzofurans (PFDD/PFDF) in rats
Q46494475Metabolic challenge to glia activates an adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves
Q72000469Metabolic differences between primary cultures of astrocytes and neurons from cerebellum and cerebral cortex. Effects of fluorocitrate
Q51433514Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity.
Q37701418Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase FlK.
Q53080145Multiscale analysis of enantioselectivity in enzyme-catalysed 'lethal synthesis' using projector-based embedding.
Q34417583Natural and engineered biosynthesis of fluorinated natural products.
Q38659420Neuronal P2X7 Receptors Revisited: Do They Really Exist?
Q41664928Nongenomic Glucocorticoid Suppression of a Postsynaptic Potassium Current via Emergent Autocrine Endocannabinoid Signaling in Hypothalamic Neuroendocrine Cells following Chronic Dehydration
Q46581514Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy.
Q34946408PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.
Q37518179Pharmacokinetics, metabolism, biodistribution, radiation dosimetry, and toxicology of (18)F-fluoroacetate ((18)F-FACE) in non-human primates
Q38974724Pharmacological Tools to Study the Role of Astrocytes in Neural Network Functions.
Q42148492Potentiation of the glutamatergic synaptic input to rat locus coeruleus neurons by P2X7 receptors
Q53423736Response of catecholaminergic neurons in the mouse hindbrain to glucoprivic stimuli is astrocyte dependent.
Q28363331Selectivity of protein oxidative damage during aging in Drosophila melanogaster
Q41551587Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection
Q35739759Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.
Q27664447Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity
Q46145661Synaptic transmission in the hippocampus: critical role for glial cells
Q44395113Temporal and fluoride control of secondary metabolism regulates cellular organofluorine biosynthesis.
Q39246189The acute inhibition of enteric glial metabolism with fluoroacetate alters calcium signaling, hemichannel function, and the expression of key proteins.
Q43281633The effects of centrally administered fluorocitrate via inhibiting glial cells on working memory in rats
Q30868444The glutamine-glutamate/GABA cycle: function, regional differences in glutamate and GABA production and effects of interference with GABA metabolism.
Q27734038The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex

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