Dorsal root compression produces myelinated axonal degeneration near the biomechanical thresholds for mechanical behavioral hypersensitivity

scientific article published on 17 May 2008

Dorsal root compression produces myelinated axonal degeneration near the biomechanical thresholds for mechanical behavioral hypersensitivity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.EXPNEUROL.2008.04.042
P932PMC publication ID2574512
P698PubMed publication ID18572166
P5875ResearchGate publication ID5282589

P2093author name stringBeth A Winkelstein
Raymond D Hubbard
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Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglionQ28567269
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Transient cervical nerve root compression modulates pain: load thresholds for allodynia and sustained changes in spinal neuropeptide expressionQ30481523
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ISSLS prize winner: Erythropoietin inhibits spinal neuronal apoptosis and pain following nerve root crushQ39387184
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Myelinated afferents sprout into lamina II of L3-5 dorsal horn following chronic constriction nerve injury in ratsQ41614566
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Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediatorsQ44555320
Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injuryQ44624462
Role of TNF-alpha in sensitization of nociceptive dorsal horn neurons induced by application of nucleus pulposus to L5 dorsal root ganglion in rats.Q45978852
Reduced hyperalgesia in nerve-injured WLD mice: relationship to nerve fiber phagocytosis, axonal degeneration, and regeneration in normal miceQ46495239
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Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: considerations for persistent painQ48440854
A novel rodent neck pain model of facet-mediated behavioral hypersensitivity: implications for persistent pain and whiplash injuryQ48564861
Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomyQ48722332
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Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the ratQ51533391
Mechanical thresholds for initiation and persistence of pain following nerve root injury: mechanical and chemical contributions at injuryQ51665894
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Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent NeuronsQ60705950
Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neuronsQ73067505
Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathyQ73163629
Limited role of macrophages in generation of nerve injury-induced mechanical allodyniaQ73378234
Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRGQ73629697
Injury to dorsal root ganglia alters innervation of spinal cord dorsal horn lamina involved in nociceptionQ73630454
Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibersQ73713509
Neural space integrity of the lower cervical spine: effect of normal range of motionQ77744707
The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behaviorQ77865436
Electrophysiologic changes in dorsal root ganglion neurons and behavioral changes in a lumbar radiculopathy modelQ79563109
Increase of 200-kDa neurofilament-immunoreactive afferents in the substantia gelatinosa in allodynic rats induced by compression of the dorsal root ganglionQ80362286
Spinal neuropeptide responses in persistent and transient pain following cervical nerve root injuryQ81473314
The histologic effects of pulsed and continuous radiofrequency lesions at 42 degrees C to rat dorsal root ganglion and sciatic nerveQ81703328
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectbiomechanicsQ193378
myelinationQ14876135
P304page(s)482-489
P577publication date2008-05-17
P1433published inExperimental NeurologyQ5421127
P1476titleDorsal root compression produces myelinated axonal degeneration near the biomechanical thresholds for mechanical behavioral hypersensitivity
P478volume212

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cites work (P2860)
Q35209440Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction
Q27314656Bilateral Neuropathy of Primary Sensory Neurons by the Chronic Compression of Multiple Unilateral DRGs
Q34281968Bilateral sensory abnormalities in patients with unilateral neuropathic pain; a quantitative sensory testing (QST) study
Q47851679Brain-derived neurotrophic factor is upregulated in the cervical dorsal root ganglia and spinal cord and contributes to the maintenance of pain from facet joint injury in the rat
Q89573301Changes in Neuronal Activity in the Anterior Cingulate Cortex and Primary Somatosensory Cortex With Nonlinear Burst and Tonic Spinal Cord Stimulation
Q83372138Changes in synaptic transmission of substantia gelatinosa neurons in a rat model of lumbar radicular pain revealed by in vivo patch-clamp recording
Q35601040How Can Animal Models Inform on the Transition to Chronic Symptoms in Whiplash?
Q35053403Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1
Q84591543Schwann Cell Proliferation and Macrophage Infiltration Are Evident at Day 14 after Painful Cervical Nerve Root Compression in the Rat
Q36995630Spinal Facet Joint Biomechanics and Mechanotransduction in Normal, Injury and Degenerative Conditions
Q35376544The potential for salmon fibrin and thrombin to mitigate pain subsequent to cervical nerve root injury
Q36833054Tissue Strain Reorganizes Collagen With a Switchlike Response That Regulates Neuronal Extracellular Signal-Regulated Kinase Phosphorylation In Vitro: Implications for Ligamentous Injury and Mechanotransduction
Q42833526Transient receptor potential ankyrin 1 in spinal cord dorsal horn is involved in neuropathic pain in nerve root constriction rats
Q45029579Upregulation of GLT-1 by treatment with ceftriaxone alleviates radicular pain by reducing spinal astrocyte activation and neuronal hyperexcitability
Q36010787Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity

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