Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics

scientific article published on 10 May 2007

Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1039/B514050C
P698PubMed publication ID17898898
P5875ResearchGate publication ID5945604

P2093author name stringStefano Donadio
Margherita Sosio
Paolo Monciardini
P2860cites workSymbiobacterium thermophilum gen. nov., sp. nov., a symbiotic thermophile that depends on co-culture with a Bacillus strain for growthQ30617277
Identification and partial characterization of the nonribosomal peptide synthetase gene responsible for cereulide production in emetic Bacillus cereusQ33721101
Photobactin: a catechol siderophore produced by Photorhabdus luminescens, an entomopathogen mutually associated with Heterorhabditis bacteriophora NC1 nematodes.Q39804891
Brucella abortus strain 2308 produces brucebactin, a highly efficient catecholic siderophore.Q40752306
Genomics of pyoverdine-mediated iron uptake in pseudomonadsQ44462050
Comparison of the genomes of two Xanthomonas pathogens with differing host specificitiesQ22122346
Genome sequence of the plant pathogen Ralstonia solanacearumQ22122347
The complete genome sequence of the gastric pathogen Helicobacter pyloriQ22122352
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferiQ22122357
The complete genome sequence of the gram-positive bacterium Bacillus subtilisQ22122360
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2Q22122369
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18Q22122370
Genome sequence of Yersinia pestis, the causative agent of plagueQ22122371
Massive gene decay in the leprosy bacillusQ22122381
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7Q22122385
The complete sequence of the mucosal pathogen Ureaplasma urealyticumQ22122390
Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APSQ22122392
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogenQ22122393
DNA sequence of both chromosomes of the cholera pathogen Vibrio choleraeQ22122394
The genome sequence of the plant pathogen Xylella fastidiosa. The Xylella fastidiosa Consortium of the Organization for Nucleotide Sequencing and AnalysisQ22122395
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491Q22122399
The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequencesQ22122402
The complete genome of the hyperthermophilic bacterium Aquifex aeolicusQ22122406
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceQ22122411
The genome sequence of Rickettsia prowazekii and the origin of mitochondriaQ22122428
Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritimaQ22122435
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pyloriQ22122443
P433issue5
P921main subjectgenomicsQ222046
P304page(s)1073-1109
P577publication date2007-05-10
P1433published inNatural Product ReportsQ2376904
P1476titlePolyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics
P478volume24

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cites work (P2860)
Q35897260A Novel Depsipeptide Produced by Paenibacillus alvei 32 Isolated from a Cystic fibrosis Patient
Q37132922A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis
Q38069492A genomic approach to the cryptic secondary metabolome of the anaerobic world
Q35672338A mass spectrometry-guided genome mining approach for natural product peptidogenomics
Q82605455A novel docking domain interface model predicting recombination between homoeologous modular biosynthetic gene clusters
Q36517087Acetylome analysis reveals the involvement of lysine acetylation in biosynthesis of antibiotics in Bacillus amyloliquefaciens
Q28658500Actinomycetes from Red Sea sponges: sources for chemical and phylogenetic diversity
Q57049404Advancing Weed Management Strategies Using Metagenomic Techniques
Q42544847An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics
Q40494065An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products
Q38031395Anaerobic bacteria as producers of antibiotics
Q33805179Analysis of the Pantoea ananatis pan-genome reveals factors underlying its ability to colonize and interact with plant, insect and vertebrate hosts.
Q47810361Antibacterial aryl-crowned polyketide from Bacillus subtilis associated with seaweed Anthophycus longifolius
Q35043670Antimicrobial activity of heterotrophic bacterial communities from the marine sponge Erylus discophorus (Astrophorida, Geodiidae)
Q39158546Antiviral activity of Bacillus sp. isolated from the marine sponge Petromica citrina against bovine viral diarrhea virus, a surrogate model of the hepatitis C virus
Q46256225Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor
Q33834986Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes.
Q91362713Bacterial siderophores in community and host interactions
Q38000475Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics
Q64063195Bioactivities and Extract Dereplication of Isolated From Marine Sponges
Q36426194Bioactivities by a crude extract from the Greenlandic Pseudomonas sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin.
Q39390812Bioinformatic evaluation of the secondary metabolism of antistaphylococcal environmental bacterial isolates
Q38156708Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides
Q35095005Bioprospecting from marine sediments of New Brunswick, Canada: exploring the relationship between total bacterial diversity and actinobacteria diversity
Q28816952Burkholderia paludis sp. nov., an Antibiotic-Siderophore Producing Novel Burkholderia cepacia Complex Species, Isolated from Malaysian Tropical Peat Swamp Soil
Q83677579Chapter 1. Approaches to discovering novel antibacterial and antifungal agents
Q42249418Chemical and biosynthetic evolution of the antimycin-type depsipeptides
Q35097066Chemical-biogeographic survey of secondary metabolism in soil
Q34700983Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models
Q35371319ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides
Q37699551Cloning and Heterologous Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in Streptomyces Species
Q42316131Comparative Genomics of Four Isosphaeraceae Planctomycetes: A Common Pool of Plasmids and Glycoside Hydrolase Genes Shared by Paludisphaera borealis PX4T, Isosphaera pallida IS1BT, Singulisphaera acidiphila DSM 18658T, and Strain SH-PL62.
Q35984452Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain
Q46848737Comparative genomics revealed key molecular targets to rapidly convert a reference rifamycin-producing bacterial strain into an overproducer by genetic engineering.
Q36391733Complete gene expression profiling of Saccharopolyspora erythraea using GeneChip DNA microarrays
Q33529869Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion
Q27644463Conformational changes associated with the binding of zinc acetate at the putative active site of Xc TcmJ, a cupin from Xanthomonas campestris pv. campestris
Q44176209Culturable endophytes of medicinal plants and the genetic basis for their bioactivity
Q33712859Current approaches to exploit actinomycetes as a source of novel natural products.
Q46714174Databases of the thiotemplate modular systems (CSDB) and their in silico recombinants (r-CSDB).
Q28548367Designing and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban Soils
Q38824318Developing Techniques for the Utilization of Planctomycetes As Producers of Bioactive Molecules
Q38198771Discovering new bioactive molecules from microbial sources.
Q26752366Discovery Strategies of Bioactive Compounds Synthesized by Nonribosomal Peptide Synthetases and Type-I Polyketide Synthases Derived from Marine Microbiomes
Q61774159Discovery of Clostrubin, an Exceptional Polyphenolic Polyketide Antibiotic from a Strictly Anaerobic Bacterium
Q38539563Discovery of microbial natural products by activation of silent biosynthetic gene clusters
Q61801050Diversified secondary metabolite biosynthesis gene repertoire revealed in symbiotic dinoflagellates
Q43027122Diversity of Culturable Thermophilic Actinobacteria in Hot Springs in Tengchong, China and Studies of their Biosynthetic Gene Profiles
Q33330103Diversity of microbes associated with the marine sponge, Haliclona simulans, isolated from Irish waters and identification of polyketide synthase genes from the sponge metagenome.
Q55515931Draft Genome Sequence of the Antimicrobial-Producing Strain Paenibacillus elgii AC13.
Q34731071Enhancing microbial metabolite and enzyme production: current strategies and challenges
Q43202040Erythrochelin--a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea
Q91987138Evolution and Diversity of Assembly-Line Polyketide Synthases
Q37174144Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases
Q37694423Exploring the Antimicrobial and Antitumor Potentials of Streptomyces sp. AGM12-1 Isolated from Egyptian Soil
Q28829854Exploring the Diversity and Antimicrobial Potential of Marine Actinobacteria from the Comau Fjord in Northern Patagonia, Chile
Q44674313From genome mining to phenotypic microarrays: Planctomycetes as source for novel bioactive molecules
Q45381468Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting.
Q37914045Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery
Q57295951Functional and evolutionary characterization of a secondary metabolite gene cluster in budding yeasts
Q35952276Genetic and Functional Analysis of the Biosynthesis of a Non-Ribosomal Peptide Siderophore in Burkholderia xenovorans LB400
Q38283421Genetic and biochemical map for the biosynthesis of occidiofungin, an antifungal produced by Burkholderia contaminans strain MS14.
Q35034666Genetic approach for the fast discovery of phenazine producing bacteria
Q41597878Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri
Q64085042Genome Features and Secondary Metabolites Biosynthetic Potential of the Class
Q37185511Genome Sequence of Saccharopolyspora erythraea D, a Hyperproducer of Erythromycin
Q35763602Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria
Q31140206Genome mining reveals the genus Xanthomonas to be a promising reservoir for new bioactive non-ribosomally synthesized peptides
Q38429580Genome mining: Prediction of lipopeptides and polyketides from Bacillus and related Firmicutes
Q38258173Genome mining: concept and strategies for natural product discovery.
Q55501475Genomic Insight into Symbiosis-Induced Insect Color Change by a Facultative Bacterial Endosymbiont, "Candidatus Rickettsiella viridis".
Q39356909Genomic analysis by deep sequencing of the probiotic Lactobacillus brevis KB290 harboring nine plasmids reveals genomic stability
Q34711979Genomic basis for natural product biosynthetic diversity in the actinomycetes
Q34484330Genomic insights into strategies used by Xanthomonas albilineans with its reduced artillery to spread within sugarcane xylem vessels
Q42963295Genomics and the ancient origins of the daptomycin biosynthetic gene cluster
Q36966213Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43
Q39607777Genus-specific primers targeting the 16S rRNA gene for PCR detection of members of the genus Verrucosispora
Q50529262Gifted microbes for genome mining and natural product discovery.
Q35249557Global biogeographic sampling of bacterial secondary metabolism
Q34197910Granaticins and their biosynthetic gene cluster from Streptomyces vietnamensis: evidence of horizontal gene transfer
Q33750113Heterologous expression of pikromycin biosynthetic gene cluster using Streptomyces artificial chromosome system
Q37341890How nature morphs peptide scaffolds into antibiotics
Q41463199Identification of Secondary Metabolite Gene Clusters in the Pseudovibrio Genus Reveals Encouraging Biosynthetic Potential toward the Production of Novel Bioactive Compounds
Q37256182Identification of a polyketide synthase coding sequence specific for anatoxin-a-producing Oscillatoria cyanobacteria
Q91821677Individual- versus group-optimality in the production of secreted bacterial compounds
Q46600999Informatic analysis reveals Legionella as a source of novel natural products
Q46140378Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.
Q46763789Isolation and analysis of bacteria with antimicrobial activities from the marine sponge Haliclona simulans collected from Irish waters.
Q28545076Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis
Q37010777MS/MS networking guided analysis of molecule and gene cluster families.
Q38325047Magnetotactic bacteria as potential sources of bioproducts.
Q50529406MbtH homology codes to identify gifted microbes for genome mining.
Q34428178Metagenomic small molecule discovery methods
Q33804081Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?
Q51451071Mind the PVCs.
Q35829462Mining for Nonribosomal Peptide Synthetase and Polyketide Synthase Genes Revealed a High Level of Diversity in the Sphagnum Bog Metagenome.
Q34690302Molecular richness and biotechnological potential of bacteria cultured from Irciniidae sponges in the north-east Atlantic.
Q37735905Natural functions of lipopeptides from Bacillus and Pseudomonas: more than surfactants and antibiotics.
Q89147783Natural products from thioester reductase containing biosynthetic pathways
Q42924476Natural products genomics
Q34096062Natural products version 2.0: connecting genes to molecules.
Q51268481O-heterocyclic derivatives with antibacterial properties from marine bacterium Bacillus subtilis associated with seaweed, Sargassum myriocystum.
Q33813655Oligopeptides as biomarkers of cyanobacterial subpopulations. Toward an understanding of their biological role.
Q37273353Paenimacrolidin, a novel macrolide antibiotic from Paenibacillus sp. F6-B70 active against methicillin-resistant Staphylococcus aureus
Q37154618Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production
Q26999592Planctomycetes and macroalgae, a striking association
Q37169895Planctomycetes as Novel Source of Bioactive Molecules
Q37536389Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts.
Q35432515Polyketide synthases in the microbiome of the marine sponge Plakortis halichondrioides: a metagenomic update
Q36068835Precise cloning and tandem integration of large polyketide biosynthetic gene cluster using Streptomyces artificial chromosome system
Q34259264Prescreening bacterial colonies for bioactive molecules with Janus plates, a SBS standard double-faced microbial culturing system
Q35013299Proteomics-based discovery of koranimine, a cyclic imine natural product
Q61558049Pyranonigrin E: a PKS-NRPS hybrid metabolite from Aspergillus niger identified by genome mining
Q33957606SBSPKS: structure based sequence analysis of polyketide synthases
Q41859122Secondary metabolite genes encoded by potato rhizosphere microbiomes in the Andean highlands are diverse and vary with sampling site and vegetation stage
Q90570253Secondary metabolite production and the safety of industrially important members of the Bacillus subtilis group
Q33875171Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses.
Q36926801Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca
Q39472787Synthesis of natural variants and synthetic derivatives of the cyclic nonribosomal peptide luminmide in permeabilized E. coli Nissle and product formation kinetics.
Q91971521Taxonomy and Broad-Spectrum Antifungal Activity of Streptomyces sp. SCA3-4 Isolated From Rhizosphere Soil of Opuntia stricta
Q42127880The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated "magic" RNA polymerase
Q33782231The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence
Q21563336The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion
Q44521914The genus Actinoallomurus and some of its metabolites.
Q38023179The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways.
Q34590208Transcriptome and proteome exploration to provide a resource for the study of Agrocybe aegerita
Q34391877Transcriptomic analysis reveals new regulatory roles of Clp signaling in secondary metabolite biosynthesis and surface motility in Lysobacter enzymogenes OH11.
Q52628180Type II thioesterase gene (ECO-orf27) from Amycolatopsis orientalis influences production of the polyketide antibiotic, ECO-0501 (LW01).
Q35621353Use of Metagenomics and Isolation of Actinobacteria in Brazil's Atlantic Rainforest Soil for Antimicrobial Prospecting

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