Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia

scientific article published on June 2016

Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1038119069
P356DOI10.1186/S13014-016-0647-1
P2888exact matchhttps://scigraph.springernature.com/pub.10.1186/s13014-016-0647-1
P932PMC publication ID4888512
P698PubMed publication ID27251632

P50authorJohann MatschkeQ89057705
P2093author name stringVerena Jendrossek
Sebastian Hurst
Justine Rudner
Elisa Wiebeck
P2860cites workSignificance of SGK1 in the regulation of neuronal functionQ24317440
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Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
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Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivoQ35024044
NDRG2 phosphorylation provides negative feedback for SGK1-dependent regulation of a kainate receptor in astrocytesQ36123449
Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapyQ36545796
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Free fatty acid palmitate activates unfolded protein response pathway and promotes apoptosis in meniscus cellsQ36818380
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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipidsQ36895786
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Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1.Q38177872
Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.Q38545109
The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cellsQ38624425
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Lipid desaturation - the next step in targeting lipogenesis in cancer?Q38735369
Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia.Q38782792
Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cellsQ39544108
Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells.Q39561471
Characterization of the serum metabolome following radiation treatment in patients with high-grade gliomasQ39817583
Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis.Q39936514
Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.Q39939547
SGK1 kinase upregulates GLUT1 activity and plasma membrane expressionQ40323679
Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer: the HIL trialQ41686423
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Livin contributes to tumor hypoxia-induced resistance to cytotoxic therapies in glioblastoma multiformeQ48181079
Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1.Q48653353
Biology of hypoxia.Q51656540
Impaired fatty acid oxidation as a cause for lipotoxicity in cardiomyocytes.Q53657553
Crystal Violet Assay for Determining Viability of Cultured Cells.Q54340969
Ypk1, the yeast orthologue of the human serum- and glucocorticoid-induced kinase, is required for efficient uptake of fatty acids.Q54671084
Expression of cell volume-regulated kinase h-sgk in pancreatic tissueQ73127395
Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683Q86068038
P4510describes a project that usesImageJQ1659584
P921main subjectfatty acidQ61476
P304page(s)75
P577publication date2016-06-01
P1433published inRadiation OncologyQ2313370
P1476titleRole of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia
P478volume11

Reverse relations

cites work (P2860)
Q47891451Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells
Q61804436Oxidative stress: the lowest common denominator of multiple diseases
Q64102265Rationale for Combining Radiotherapy and Immune Checkpoint Inhibition for Patients With Hypoxic Tumors
Q91814537Targeting mTOR and Metabolism in Cancer: Lessons and Innovations
Q54978893The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia.
Q98164823The prospect of serum and glucocorticoid-inducible kinase 1 (SGK1) in cancer therapy: a rising star

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