Genetics of pancreatic neuroendocrine tumors: implications for the clinic

scientific article published on 28 September 2015

Genetics of pancreatic neuroendocrine tumors: implications for the clinic is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1586/17474124.2015.1092383
P932PMC publication ID4890468
P698PubMed publication ID26413978

P50authorRalph H. HrubanQ21063634
Antonio PeaQ56816595
P2093author name stringLaura D Wood
P2860cites workMenin interacts with the AP1 transcription factor JunD and represses JunD-activated transcriptionQ22001458
Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signalingQ24290996
Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23Q24291124
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivationQ24291618
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeresQ24292850
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Menin associates with FANCD2, a protein involved in repair of DNA damageQ24310300
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitorsQ24337658
A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severityQ24514960
Molecular genetics of neurofibromatosis type 1 (NF1)Q24518449
mTOR signaling in growth control and diseaseQ24634174
Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversiesQ24647838
Zollinger-Ellison syndrome associated with neurofibromatosis type 1: a case reportQ24815486
A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressorQ27003534
Lanreotide in metastatic enteropancreatic neuroendocrine tumorsQ28243728
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR functionQ28254826
Distinct factors control histone variant H3.3 localization at specific genomic regionsQ28275277
Clinical pathology of endocrine tumors of the pancreas. Analysis of autopsy casesQ28290384
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumorsQ28303693
Positional cloning of the gene for multiple endocrine neoplasia-type 1Q28307577
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4cQ28506197
Menin induces apoptosis in murine embryonic fibroblastsQ28589504
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancerQ29618030
Identification of the von Hippel-Lindau disease tumor suppressor geneQ29618644
Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndromeQ30815312
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinomaQ48100816
Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors.Q50761477
Natural course of small, asymptomatic neuroendocrine pancreatic tumours in multiple endocrine neoplasia type 1: an endoscopic ultrasound imaging study.Q50794017
Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients.Q53272124
Type 1 neurofibromatosis: a descriptive analysis of the disorder in 1,728 patients.Q53359692
Endocrine pancreatic tumors in von Hippel-Lindau disease: clinical, histological, and genetic features.Q53407685
[Neurofibromatosis von Recklinghausen type 1 (NF1) - clinical picture and molecular-genetics diagnostic].Q54291303
High resolution allelotype of nonfunctional pancreatic endocrine tumors: identification of two molecular subgroups with clinical implications.Q54469598
Pancreatic endocrine tumors are a rare manifestation of the neurofibromatosis type 1 phenotype: molecular analysis of a malignant insulinoma in a NF-1 patient.Q54590983
Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme.Q55472960
Somatostatin receptorsQ58448612
Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survivalQ59647330
Pancreatic involvement in von Hippel–Lindau diseaseQ62929393
Streptozocin–Doxorubicin, Streptozocin–Fluorouracil, or Chlorozotocin in the Treatment of Advanced Islet-Cell CarcinomaQ67485775
Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndromeQ68084123
Long-term treatment of a VIPoma with somatostatin analogue resulting in remission of symptoms and possible shrinkage of metastasesQ69855897
[Recklinghausen's disease with digestive localizations associated with gastric acid hypersecretion suggesting Zollinger-Ellison syndrome]Q69940608
Streptozocin Alone Compared with Streptozocin plus Fluorouracil in the Treatment of Advanced Islet-Cell CarcinomaQ72866285
Loss of heterozygosity of chromosome 1q in gastrinomas: occurrence and prognostic significanceQ73013904
Clinical and genetic analysis of patients with pancreatic neuroendocrine tumors associated with von Hippel-Lindau diseaseQ73292303
Clinical impact of somatostatin receptor scintigraphy in the management of patients with neuroendocrine gastroenteropancreatic tumorsQ73428887
Genetic evidence for early divergence of small functioning and nonfunctioning endocrine pancreatic tumors: gain of 9Q34 is an early event in insulinomasQ74114518
Expression of vascular endothelial growth factor in digestive neuroendocrine tumoursQ74447035
INSULINOMA AND MULTIPLE NEUROFIBROMATOSIS: REPORT OF A CASEQ76801912
Multiple endocrine neoplasia type 1: clinical and genetic topicsQ77292736
Genomic imbalances in the progression of endocrine pancreatic tumorsQ77361239
Chromosome 22q in pancreatic endocrine tumors: identification of a homozygous deletion and potential prognostic associations of allelic deletionsQ78346047
An aggressive surgical approach leads to long-term survival in patients with pancreatic endocrine tumorsQ79378332
Molecular parameters associated with insulinoma progression: chromosomal instability versus p53 and CK19 statusQ79379768
Chromosomal instability predicts metastatic disease in patients with insulinomasQ81832529
HIRA and Daxx Constitute Two Independent Histone H3.3-Containing Predeposition ComplexesQ82295373
[Type I neurofibromatosis, pheochromocytoma and somatostatinoma of the ampulla. Literature review]Q82323609
Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1Q83300174
Clinical effect of temozolomide-based chemotherapy in poorly differentiated endocrine carcinoma after progression on first-line chemotherapyQ83761732
Perfusion computed tomography as functional biomarker in randomized run-in study of bevacizumab and everolimus in well-differentiated neuroendocrine tumorsQ86061058
The genetics of neuroendocrine tumorsQ86078968
Epidemiology data on 108 MEN 1 patients from the GTE with isolated nonfunctioning tumors of the pancreasQ31030383
Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological featuresQ33258694
Endocrine neoplasms of the pancreas: pathologic and genetic featuresQ33414797
PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumorsQ33767655
The NF1 tumor suppressor critically regulates TSC2 and mTOR.Q33841600
Multiple endocrine neoplasia type 1.Q33871564
Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumorsQ34010378
Sunitinib malate for the treatment of pancreatic neuroendocrine tumorsQ34163515
Altered telomeres in tumors with ATRX and DAXX mutationsQ34196696
ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms of the digestive system: well-differentiated pancreatic non-functioning tumorsQ34248466
Everolimus for advanced pancreatic neuroendocrine tumors.Q34399809
The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms.Q34464857
Malignant endocrine tumor of the pancreas associated with von Recklinghausen's diseaseQ34514963
Hereditary pancreatic endocrine tumours.Q34549251
Tumour hypoxia, hypoxia signaling pathways and hypoxia inducible factor expression in human cancer.Q34573905
Population-based study of islet cell carcinomaQ34693373
Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patientsQ34729926
Neurofibromatosis, phaeochromocytoma, and somatostatinomaQ34766709
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathwayQ34887795
Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trialQ34965132
Multicenter Phase II Trial of Temsirolimus and Bevacizumab in Pancreatic Neuroendocrine TumorsQ35563828
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTORQ35613890
Mutation-targeted therapy with sunitinib or everolimus in patients with advanced low-grade or intermediate-grade neuroendocrine tumours of the gastrointestinal tract and pancreas with or without cytoreductive surgery: protocol for a phase II clinicaQ35640506
Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumorsQ35681234
Multiple neuroendocrine tumors of the pancreas in von Hippel-Lindau disease patients: histopathological and molecular genetic analysisQ35753186
Chromosomal alterations detected by comparative genomic hybridization in nonfunctioning endocrine pancreatic tumorsQ35978878
Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?Q36300517
First‐line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomasQ36335402
Von Hippel-Lindau disease and endocrine tumour susceptibilityQ36489892
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumorsQ36541359
Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progressionQ36615803
Treatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatinQ36620016
Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005.Q36793415
Targeting ALT: the role of alternative lengthening of telomeres in pathogenesis and prevention of cancerQ36969406
Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: results of a phase II studyQ37121673
Pancreatic neuroendocrine tumors: approach to treatment with focus on sunitinibQ37130616
Tuberous sclerosis: unusual associations in four casesQ37180044
One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United StatesQ37195528
Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potentialQ37241681
Everolimus in postmenopausal, hormone receptor-positive advanced breast cancer: summary and results of an austrian expert panel discussionQ37255122
Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survivalQ37326199
An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomesQ37459597
Periampullary and duodenal neoplasms in neurofibromatosis type 1: two cases and an updated 20-year review of the literature yielding 76 casesQ37714407
Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapyQ37773478
The epidemiology of gastroenteropancreatic neuroendocrine tumors.Q37846915
Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 studyQ37961390
Neuroendocrine tumors of the pancreas: current concepts and controversies.Q38178882
Loss of heterozygosity in 11q13-14 regions in gastric neuroendocrine tumors not associated with multiple endocrine neoplasia type 1 syndrome.Q38468233
Suppression of mTOR pathway in solid tumors: lessons learned from clinical experience in renal cell carcinoma and neuroendocrine tumors and new perspectives.Q38527936
Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.Q38862463
Cytological differentiation of asymptomatic pancreatic islet cell tumours in autopsy materialQ39316548
Menin represses JunD transcriptional activity in protein kinase C theta-mediated Nur77 expressionQ40355558
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesisQ40359760
Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcomaQ40593218
bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.Q42505657
Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study GroupQ43286770
VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumorsQ43290089
Treatment with cisplatin and etoposide in patients with neuroendocrine tumorsQ43747293
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell linesQ43864431
Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC studyQ43905778
In- and Y-DOTA-lanreotide: results and implications of the MAURITIUS trialQ43966911
Risk factors and causes of death in MEN1 disease. A GTE (Groupe d'Etude des Tumeurs Endocrines) cohort study among 758 patientsQ44301609
MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of casesQ44303888
Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomasQ44582807
Metastatic and locally advanced pancreatic endocrine carcinomas: analysis of factors associated with disease progression.Q44646733
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.Q44732861
The pharmacology of mTOR inhibitionQ46041824
Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13.Q46229550
Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumorQ46562102
Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survivalQ46619794
Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumorsQ46900223
Bevacizumab combined with 5-FU/streptozocin in patients with progressive metastatic well-differentiated pancreatic endocrine tumours (BETTER trial)--a phase II non-randomised trial.Q48057935
P433issue11
P304page(s)1407-1419
P577publication date2015-09-28
P1433published inExpert Review of Gastroenterology & HepatologyQ15733730
P1476titleGenetics of pancreatic neuroendocrine tumors: implications for the clinic
P478volume9

Reverse relations

cites work (P2860)
Q47170689Assessment of pancreatic neuroendocrine tumor cytologic genotype diversity to guide personalized medicine using a custom gastroenteropancreatic next-generation sequencing panel
Q49957735Current and emerging therapies for PNETs in patients with or without MEN1.
Q98612725Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations
Q26748615Surgical and molecular pathology of pancreatic neoplasms
Q91595896Zebrafish patient avatars in cancer biology and precision cancer therapy

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