HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma

scientific article published on 24 June 2013

HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI65566
P932PMC publication ID3696564
P698PubMed publication ID23934123

P50authorPaul A TrainorQ48687276
P2093author name stringPaul A Trainor
Han Liu
Emily H Cheng
James J Hsieh
Shugaku Takeda
Yiyu Dong
Satoru Sasagawa
P2860cites workTaspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expressionQ24300473
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Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cellsQ40782785
Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genesQ40876225
Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cellsQ40993570
The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteinsQ41080680
Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusionsQ41436188
Human corneal epithelial cells require MMP-1 for HGF-mediated migration on collagen I.Q42437431
Mechanisms of hepatocyte growth factor stimulation of keratinocyte metalloproteinase productionQ42522963
Scatter factor is a fibroblast-derived modulator of epithelial cell mobilityQ42807925
The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factorQ47929963
Ets-1 transcription factor-mediated urokinase-type plasminogen activator expression and invasion in glioma cells stimulated by serum and basic fibroblast growth factorsQ48231412
Hoxa3 Regulates Integration of Glossopharyngeal Nerve Precursor CellsQ52125398
The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axonsQ52169915
Regulation of Pax-3 expression in the dermomyotome and its role in muscle developmentQ52217598
E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.Q52681173
Inhibition of vascular endothelial growth factor-induced endothelial cell migration by ETS1 antisense oligonucleotidesQ73352924
Invasiveness of hepatocellular carcinoma cell lines: contribution of hepatocyte growth factor, c-met, and transcription factor Ets-1Q74438273
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Uncleaved TFIIA is a substrate for taspase 1 and active in transcriptionQ24548040
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Met, metastasis, motility and moreQ28235183
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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb budQ28506228
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axisQ28588504
Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) geneQ28590721
Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4Q28592544
Hox Group 3 Paralogous Genes Act Synergistically in the Formation of Somitic and Neural Crest-Derived StructuresQ28593097
MLL targets SET domain methyltransferase activity to Hox gene promotersQ28609771
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Hox genes in vertebrate developmentQ29618109
Matrix metalloproteinases: regulators of the tumor microenvironmentQ29619858
Altered Hox expression and segmental identity in Mll-mutant miceQ29620391
Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.Q30355361
Semi-automated quantification of axonal densities in labeled CNS tissueQ33233560
Hepatocyte growth factor, a versatile signal for developing neuronsQ33589398
Regulation of matrix metalloproteinase expression in tumor invasion.Q33605726
Mouse models in the study of the Ets family of transcription factorsQ34139383
Molecular genetics of cranial nerve development in mouseQ34354367
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.Q34563234
Mutant alleles of the Drosophila trithorax gene produce common and unusual homeotic and other developmental phenotypes.Q34606947
Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathwaysQ35041289
How to make tubes: signaling by the Met receptor tyrosine kinaseQ35147372
Homeotic transformation of cervical vertebrae in Hoxa-4 mutant miceQ35996071
Targeting the HGF/Met signalling pathway in cancer.Q36142604
Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathwaysQ36315316
Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic developmentQ36745250
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Therapeutic targeting of MLL.Q37234595
Pten in stromal fibroblasts suppresses mammary epithelial tumoursQ37399478
Two independent activation domains in c-Ets-1 and c-Ets-2 located in non-conserved sequences of the ets gene familyQ38330702
The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sitesQ38340236
Induction of multiple matrix metalloproteinase genes in human hepatocellular carcinoma by hepatocyte growth factor via a transcription factor Ets-1.Q38347090
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)3154-3165
P577publication date2013-06-24
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleHGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma
P478volume123

Reverse relations

cites work (P2860)
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