Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: What is the appropriate serum level?

scientific article published on July 2010

Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: What is the appropriate serum level? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1600-6143.2010.03152.X
P932PMC publication ID3697013
P698PubMed publication ID20642692
P5875ResearchGate publication ID239977486

P2093author name stringF Martinez
C Legendre
G Canaud
P C Harris
J-M Correas
N Pallet
E Thervet
F Terzi
E Letavernier
C M Heyer
B Knebelmann
F Vrtovsnik
F Bienaimé
P2860cites workAutosomal dominant polycystic kidney disease: the last 3 yearsQ24656249
TOR signaling in growth and metabolismQ27860757
A mitotic transcriptional switch in polycystic kidney diseaseQ30498985
Polycystic kidney diseaseQ33709685
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney diseaseQ34600282
Measured GFR as a confirmatory test for estimated GFR.Q34659317
Transplantation of a cadaveric polycystic kidney in a patient with autosomal dominant polycystic kidney disease: long-term outcomeQ35835110
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1Q36549183
Sirolimus reduces polycystic liver volume in ADPKD patientsQ36667245
Mammalian target of rapamycin and caspase inhibitors in polycystic kidney diseaseQ37202501
Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney diseaseQ42927109
Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohortQ44545045
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.Q44732861
Rapamycin markedly slows disease progression in a rat model of polycystic kidney diseaseQ45162599
Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).Q46749984
Superior outcomes in renal transplantation after early cyclosporine withdrawal and sirolimus maintenance therapy, regardless of baseline renal functionQ46825310
Biochemical monitoring of mTOR inhibitor-based immunosuppression following kidney transplantation: a novel approach for tailored immunosuppressive therapyQ46826521
Reduced exposure to calcineurin inhibitors in renal transplantationQ46840533
The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.Q52549447
The polycystic kidney donorQ67966367
Transplant of a polycystic kidney because of organ shortageQ68756014
Successful use of cadaver kidneys from diabetic donors for transplantationQ68756022
Development of polycystic disease in a kidney 10 years after transplantationQ73253952
Polycystic kidney patient as a cadaveric donor: is it appropriate?Q73398135
Volumetric measurement of renal cysts and parenchyma using MRI: phantoms and patients with polycystic kidney diseaseQ74245216
Polycystic kidney diseaseQ75230730
Comprehensive molecular diagnostics in autosomal dominant polycystic kidney diseaseQ80507407
High sirolimus levels may induce focal segmental glomerulosclerosis de novoQ80797353
Volume progression in polycystic kidney diseaseQ94478608
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectautosomal dominant polycystic kidney diseaseQ15443105
autosomal dominant polycystic kidneyQ2732398
P304page(s)1701-1706
P577publication date2010-07-01
P1433published inAmerican Journal of TransplantationQ4744273
P1476titleTherapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: What is the appropriate serum level?
P478volume10

Reverse relations

cites work (P2860)
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Q47742358Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade
Q92019794Autosomal dominant polycystic kidney disease
Q38812543Clinical Trials and a View Toward the Future of ADPKD.
Q35917458Dose-dependent effects of sirolimus on mTOR signaling and polycystic kidney disease
Q54117927Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease.
Q89029564Effect of Sirolimus on Native Total Kidney Volume After Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Pilot Study
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Q27320627Effects of TORC1 Inhibition during the Early and Established Phases of Polycystic Kidney Disease
Q27001230Experimental therapies and ongoing clinical trials to slow down progression of ADPKD
Q36280381Folate-conjugated rapamycin slows progression of polycystic kidney disease
Q28299654Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling
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Q27303409Improved Structure and Function in Autosomal Recessive Polycystic Rat Kidneys with Renal Tubular Cell Therapy
Q41463847Inadvertent transmission of polycystic kidney disease in kidney transplantation
Q38067358Looking at the (w)hole: magnet resonance imaging in polycystic kidney disease
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Q44767368mTOR inhibition in autosomal-dominant polycystic kidney disease (ADPKD): the question remains open

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