Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells

scientific article published on December 2008

Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1593/TLO.08151
P932PMC publication ID2582168
P698PubMed publication ID19043530
P5875ResearchGate publication ID23556491

P50authorEdgar Ben-JosefQ37125389
P2093author name stringMary E Davis
Aaron C Spalding
Benjamin D Zeitlin
Theodore S Lawrence
Jacques E Nor
Kari Wilder-Romans
P2860cites workVascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell linesQ24305184
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathwayQ24537174
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growthQ24561921
Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiationQ33868831
Protein kinase C inhibitors as novel anticancer drugsQ34481881
Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cellsQ35060343
Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expressionQ35745301
Prognostic significance of angiogenesis in human pancreatic cancerQ36619020
Distinct angiogenic mediators are required for basic fibroblast growth factor- and vascular endothelial growth factor-induced angiogenesis: the role of cytoplasmic tyrosine kinase c-Abl in tumor angiogenesisQ36631240
Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cellsQ40200763
Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cellsQ40333187
LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing miceQ40620827
VEGF-RII influences the prognosis of pancreatic cancerQ40687210
The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.Q40766940
Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypesQ41607785
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cellsQ42815794
Angiogenesis in pancreatic carcinoma: thymidine phosphorylase expression in stromal cells and intratumoral microvessel density as independent predictors of overall and relapse-free survivalQ43824334
The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiationQ43831996
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenograftsQ46652649
Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancerQ46897583
SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiationQ46966099
Combined effects of angiostatin and ionizing radiation in antitumour therapyQ47762838
Synergistic antiglioma activity of radiotherapy and enzastaurinQ48315412
De novo expression of vascular endothelial growth factor in human pancreatic cancer: evidence for an autocrine mitogenic loop.Q52968592
High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas.Q53312459
Both in vitro and in vivo irradiation are associated with induction of macrophage-derived fibroblast growth factorsQ70909157
Mean inactivation dose: a useful concept for intercomparison of human cell survival curvesQ71405944
Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancerQ73146362
Pancreatic tumors show high levels of hypoxiaQ73173983
Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiationQ73789765
Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapyQ74256317
Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progressionQ77554681
Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesisQ77668037
Basic fibroblast growth factor induces expression of VEGF receptor KDR through a protein kinase C and p44/p42 mitogen-activated protein kinase-dependent pathwayQ77759145
FGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injuryQ77788952
Enhancement of tumor radioresponse in vivo by gemcitabineQ77804784
Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesisQ78257398
Protein kinase B/Akt-dependent phosphorylation of glycogen synthase kinase-3beta in irradiated vascular endotheliumQ82606462
P433issue4
P921main subjectendotheliumQ111140
angiogenesis inhibitorQ574834
P304page(s)195-201
P577publication date2008-12-01
P1433published inTranslational OncologyQ26839583
P1476titleEnzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells
P478volume1

Reverse relations

cites work (P2860)
Q35546945Aberrant methylation of ERBB pathway genes in sporadic colorectal cancer.
Q33688600Combinatorial inhibition of Plk1 and PKCβ in cancer cells with different p53 status
Q37099594Combining molecular targeted agents with radiation therapy for malignant gliomas
Q39525805HDAC inhibitors potentiate the apoptotic effect of enzastaurin in lymphoma cells.
Q37258582Hyperglycemia regulates RUNX2 activation and cellular wound healing through the aldose reductase polyol pathway
Q33915046Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth
Q34158974Metronomic small molecule inhibitor of Bcl-2 (TW-37) is antiangiogenic and potentiates the antitumor effect of ionizing radiation
Q59072618Protein Kinase C (PKC) Isozymes and Cancer
Q37376611Two distinct types of the inhibition of vasculogenesis by different species of charged particles

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