The Emerging Role of Interleukin-21 in Transplantation

scientific article published on August 2012

The Emerging Role of Interleukin-21 in Transplantation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4172/2155-9899.S9-002
P932PMC publication ID3699202
P698PubMed publication ID23828737

P2093author name stringJiahong Xia
Wenhao Chen
Aini Xie
Eric Dale Buras
P2860cites workInterleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte functionQ24290522
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
The AP-1 transcription factor Batf controls T(H)17 differentiationQ24644525
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cellsQ24655751
Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chainQ24673607
A critical role for IL-21 in regulating immunoglobulin productionQ28215868
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiationQ28252247
IL-21: roles in immunopathology and cancer therapyQ28262034
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6Q28288702
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine productionQ28289204
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunityQ28507088
Interleukin-21: Basic Biology and Implications for Cancer and AutoimmunityQ29042353
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysQ29614839
Follicular helper CD4 T cells (TFH)Q29615063
Essential autocrine regulation by IL-21 in the generation of inflammatory T cellsQ29616147
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsQ29616148
T cell exhaustionQ29620463
B cells as antigen presenting cellsQ33238071
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanismQ33656121
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responsesQ33656146
IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?Q34062484
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in miceQ34090173
T cell-dependent B cell activationQ34363600
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.Q34420821
The biology of interleukin-2.Q34585827
Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.Q34615453
Multiple pathways to allograft rejectionQ34649451
A fundamental role for interleukin-21 in the generation of T follicular helper cellsQ34792475
Humoral rejection in kidney transplantation: new concepts in diagnosis and treatmentQ34977911
IL-21 is an antitolerogenic cytokine of the late-phase alloimmune responseQ35561097
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factorsQ35736556
The molecular basis of IL-21-mediated proliferationQ35828741
Organ transplantation--how much of the promise has been realized?Q36152685
IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses.Q36228226
Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejectionQ36350198
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.Q36402501
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cellsQ37061850
IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor.Q37078696
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotypeQ37081632
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa miceQ37083674
Interleukin-21 is required for the development of type 1 diabetes in NOD miceQ37163453
Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphomaQ37729149
Interleukin-2 receptor blockade with humanized monoclonal antibody for solid organ transplantationQ37736501
Interleukin-21 triggers effector cell responses in the gutQ37777114
Targeting interleukin-21 in rheumatoid arthritisQ37789657
Interleukin-21 as a potential therapeutic target for systemic lupus erythematosusQ37812288
Molecular mechanisms of T-cell tolerance.Q37864696
Targeting B cells and antibody in transplantationQ37888770
Development and characterization of IL-21-producing CD4+ T cellsQ38845667
IL-21 is required to control chronic viral infectionQ39328817
Calcium-dependent activation of interleukin-21 gene expression in T cellsQ40425368
Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic isletsQ41887106
Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells.Q41980961
A vital role for interleukin-21 in the control of a chronic viral infectionQ42541944
Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690,550: a pilot study in de novo kidney allograft recipientsQ43297611
Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 InhibitorQ44639305
The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine modelsQ44695040
IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.Q45951121
Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primatesQ46428222
IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivoQ46546464
Regulation of gut inflammation and th17 cell response by interleukin-21.Q46659438
IL-21R on T cells is critical for sustained functionality and control of chronic viral infectionQ46697142
Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primatesQ46868410
National conference to assess antibody-mediated rejection in solid organ transplantationQ47347260
A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice.Q51738269
IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.Q53576513
A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in AutoimmunityQ59490096
Cutting Edge: IL-21 Is Not Essential for Th17 Differentiation or Experimental Autoimmune EncephalomyelitisQ62230222
Activation of Transplant Immunity: Effect of Donor Leukocytes on Thyroid Allograft RejectionQ66881205
Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissueQ73844688
P433issue2
P304page(s)1-7
P577publication date2012-08-01
P1433published inJournal of Clinical & Cellular ImmunologyQ27723807
P1476titleThe Emerging Role of Interleukin-21 in Transplantation
P478volumeSuppl 9

Reverse relations

cites work (P2860)
Q33419621Changes in follicular helper T cells in idiopathic thrombocytopenic purpura patients
Q37196640Cytokine regulation of immune tolerance
Q34978798Inducible costimulatory molecule deficiency induced imbalance of Treg and Th17/Th2 delays rejection reaction in mice undergoing allogeneic tracheal transplantation
Q36698793Mechanistic basis of immunotherapies for type 1 diabetes mellitus
Q35862078The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells

Search more.