C-Reactive Protein: An In-Depth Look into Structure, Function, and Regulation

scientific article published on 15 December 2014

C-Reactive Protein: An In-Depth Look into Structure, Function, and Regulation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2014/653045
P932PMC publication ID4897210
P698PubMed publication ID27433484
P5875ResearchGate publication ID269635485

P50authorValmore P BermúdezQ79303809
Joselyn RojasQ86538033
María Sofía MartínezQ86538037
Enrique PachecoQ96200100
Roberto AñezQ51904646
P2093author name stringCarlos Silva
Juan Salazar
Maricarmen Chacín
Mervin Chávez-Castillo
Alexandra Toledo
Yaquelin Torres
Victoria Núñez
P2860cites workSelective activation of lectin-like oxidized low-density lipoprotein receptor-1 mediates C-reactive protein-evoked endothelial vasodilator dysfunction in coronary arteriolesQ24338726
C-reactive protein increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells.Q54634787
Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells.Q54750642
Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic PlaquesQ57132361
The kidney as a second site of human C-reactive protein formation in vivoQ73022229
Complement and atherogenesis: binding of CRP to degraded, nonoxidized LDL enhances complement activationQ73083027
Immunohistochemical localization of modified C-reactive protein antigen in normal vascular tissueQ73500521
C-reactive protein induces signaling through Fc gamma RIIa on HL-60 granulocytesQ77522454
The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesisQ77531127
[C-reactive protein: cardiovascular issues of an acute-phase protein]Q80328869
Leptin induces C-reactive protein expression in vascular endothelial cellsQ80576671
Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammationQ81227859
Evidence that complement protein C1q interacts with C-reactive protein through its globular head regionQ82625735
Modified C-reactive protein interacts with platelet glycoprotein IbαQ84165501
Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts prognosis after acute coronary syndrome--a pilot studyQ84218408
Platelets affect the structure and function of C-reactive proteinQ84242242
Early verification of myocardial ischemia with a novel biomarker of acute tissue damage: C-reactive protein fractional formsQ84463393
An about-face for C-reactive protein?Q84707321
Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL--monocyte interactionsQ84819044
Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspectiveQ24594814
Statin Therapy in Metabolic Syndrome and Hypertension Post-JUPITER: What is the Value of CRP?Q24602803
C-reactive protein: a critical updateQ24672855
I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activationQ24673242
Inflammation and metabolic dysfunction: links to cardiovascular diseasesQ26851186
Role of adipokines in atherosclerosis: interferences with cardiovascular complications in rheumatic diseasesQ27008359
The physiological structure of human C-reactive protein and its complex with phosphocholineQ27618638
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final reportQ27861020
Nitric oxide synthases: structure, function and inhibitionQ28207668
Triglycerides and cardiovascular disease: a scientific statement from the American Heart AssociationQ28235865
Fcgamma receptors: old friends and new family membersQ28291895
Adipokines in inflammation and metabolic diseaseQ29620456
Topology and structure of the C1q-binding site on C-reactive proteinQ32133439
Fcgamma receptors: structure, function and role as genetic risk factors in SLEQ33697484
Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndromeQ33788524
The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout miceQ33821359
Human C-reactive protein does not promote atherosclerosis in transgenic rabbits.Q34021492
Chronic inflammation in obesity and the metabolic syndromeQ34035348
C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipidsQ34191416
Monomeric C-reactive protein alters fibrin clot properties on endothelial cellsQ34220088
Identification of acidic pH-dependent ligands of pentameric C-reactive proteinQ34285524
C-reactive ProteinQ34344434
No reduction of atherosclerosis in C-reactive protein (CRP)-deficient miceQ34675880
Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3.Q34683473
CRP enhances soluble LOX-1 release from macrophages by activating TNF-α converting enzymeQ34769808
C-reactive protein: eighty years from discovery to emergence as a major risk marker for cardiovascular diseaseQ34907912
Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptorQ34947183
Atherosclerosis-Related Functions of C-Reactive ProteinQ35073552
The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory actionQ35138588
Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cellsQ35145964
Exposing a hidden functional site of C-reactive protein by site-directed mutagenesisQ35728529
Generation of C-reactive protein and complement components in atherosclerotic plaquesQ35746446
Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRP(m).Q51717888
Studies on the interactions between C-reactive protein and complement proteins.Q52576446
C5a receptor targeting in neointima formation after arterial injury in atherosclerosis-prone mice.Q54414303
Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow.Q54566349
The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation.Q54589744
Monomeric C-reactive protein and inflammatory injury in myocardial infarctionQ42325772
C-Reactive Protein Decreases Prostacyclin Release From Human Aortic Endothelial CellsQ42450459
Inhibition of endothelial nitric oxide synthase by C-reactive protein: clinical relevanceQ43060919
C-reactive protein adversely alters the protein-protein interaction of the endothelial isoform of nitric oxide synthaseQ43062276
The homocysteine paradox.Q43236874
Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H.Q43292217
C-reactive protein induces expression of matrix metalloproteinase-9: a possible link between inflammation and plaque rupture.Q43739933
C-reactive protein isoforms differ in their effects on thrombus growthQ43887011
Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokersQ43975643
Vascular smooth muscle cell activation by C-reactive proteinQ44385110
Interaction of oxidative stress and inflammatory response in coronary plaque instability: important role of C-reactive proteinQ44477046
C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction.Q45096516
Monomeric C-reactive protein decreases acetylated LDL uptake in human endothelial cellsQ46243550
C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cellsQ46588117
Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 correlates with oxidative stress markers in stable coronary artery diseaseQ46681831
Production of modified C-reactive protein in U937-derived macrophagesQ46772279
FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthaseQ46790570
Mechanical strain induces expression of C-reactive protein in human blood vesselsQ47929761
Low density lipoprotein and very low density lipoprotein are selectively bound by aggregated C-reactive proteinQ36346658
Complement activity and pharmacological inhibition in cardiovascular diseaseQ36405114
C-reactive protein, inflammatory conditions, and cardiovascular disease riskQ36408376
C-reactive protein in atherosclerosis: A causal factor?Q36453512
Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar ratsQ36558323
Adipose tissue-derived factors: impact on health and diseaseQ36631232
Should C-reactive protein be a target of therapy?Q36783729
Impact of C-reactive protein on disease risk and its relation to dietary factors.Q36909201
Adipokines mediate inflammation and insulin resistanceQ36920864
Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk predictionQ37045449
The evolving role of C-reactive protein in atherothrombosisQ37144130
Controlling the cardiovascular disease epidemicQ37163443
C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1.Q37323477
Modulation of C-reactive protein, tumor necrosis factor-alpha, and adiponectin by diet, exercise, and weight lossQ37331151
Regulation of cell function by isoforms of C-reactive protein: a comparative analysis.Q37393773
C-reactive protein decreases endothelial nitric oxide synthase activity via uncouplingQ37408109
The binding of C-reactive protein, in the presence of phosphoethanolamine, to low-density lipoproteins is due to phosphoethanolamine-generated acidic pH.Q37416223
C-reactive protein: clinical and epidemiological perspectives.Q37599325
A significant correlation between C - reactive protein levels in blood monocytes derived macrophages versus content in carotid atherosclerotic lesionsQ37621931
C-reactive protein: how conformational changes influence inflammatory propertiesQ37627097
Monomeric C-reactive protein generation on activated platelets: the missing link between inflammation and atherothrombotic riskQ37728665
Relation of C-reactive protein to abdominal adiposityQ37770665
Dendritic cells and regulatory T cells in atherosclerosisQ38023274
C-reactive protein and atherothrombosis: Cause or effect?Q38069724
C-reactive protein and lung diseasesQ38213960
Recognition functions of pentameric C-reactive protein in cardiovascular diseaseQ38221846
C-reactive protein (CRP) aptamer binds to monomeric but not pentameric form of CRP.Q38333783
Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activationQ39494024
Expression of C-reactive protein in the human respiratory tractQ39518908
C-reactive protein: binding to lipids and lipoproteinsQ39843358
CRP is a novel ligand for the oxidized LDL receptor LOX-1.Q39878373
Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cellsQ39904920
Phylogenetic aspects of C-reactive protein and related proteinsQ40333638
Linking inflammation and thrombosis: Role of C-reactive proteinQ41332165
Interaction of C-reactive protein with artificial phosphatidylcholine bilayersQ41752082
Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loopQ41975793
Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrationsQ42021566
C-reactive protein polarizes human macrophages to an M1 phenotype and inhibits transformation to the M2 phenotypeQ42042963
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)653045
P577publication date2014-12-15
P1433published inInternational scholarly research noticesQ27726015
P1476titleC-Reactive Protein: An In-Depth Look into Structure, Function, and Regulation
P478volume2014

Reverse relations

cites work (P2860)
Q89898692Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort
Q64110033Characterization of a subgroup of non-type 2 asthma with cow's milk hypersensitivity in young subjects
Q52677743Evaluation of Potential Disease-Mediated Drug-Drug Interaction in Patients With Moderate-to-Severe Atopic Dermatitis Receiving Dupilumab.
Q92405017Functionality of C-Reactive Protein for Atheroprotection
Q64100462Structure-Function Relationships of C-Reactive Protein in Bacterial Infection
Q54946388The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis.

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