Atrophin proteins: an overview of a new class of nuclear receptor corepressors

scientific article published on 31 October 2008

Atrophin proteins: an overview of a new class of nuclear receptor corepressors is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1621/NRS.06009
P932PMC publication ID2586093
P698PubMed publication ID19043594
P5875ResearchGate publication ID23556555

P2093author name stringLei Wang
Chih-Cheng Tsai
P2860cites workCoREST: a functional corepressor required for regulation of neural-specific gene expressionQ22003747
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicityQ22009069
Translating the Histone CodeQ22065840
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Q22253866
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafnessQ22254089
Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamineQ22254109
Regulation of chromatin structure by site-specific histone H3 methyltransferasesQ24290115
Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcriptionQ24290194
The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomesQ24290517
Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fatesQ24309059
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteinsQ24310521
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressorQ24311650
Functional architecture of atrophinsQ24323171
Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domainQ24336890
ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressorsQ24522848
Nuclear receptor corepressorsQ24540376
Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressorsQ24541357
The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcriptQ24564573
Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferationQ24564760
Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3Q24599788
Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repressionQ24610596
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathwayQ24610640
ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complexQ24653699
Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expressions of the expanded alleles in the CNSQ24671945
Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genesQ40911651
SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development.Q40928736
Genomic instability in 1p and human malignanciesQ41170258
The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB.Q41178324
Molecular and genetic studies on the region of translocation and duplication in the neuroblastoma cell line NGP at the 1p36.13-p36.32 chromosomal site.Q41198214
Transcriptional repression by COUP-TF II is dependent on the C-terminal domain and involves the N-CoR variant, RIP13delta1.Q42450537
The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamilyQ43983015
Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophyQ44854729
Krüppel requirement for knirps enhancement reflects overlapping gap gene activities in the Drosophila embryoQ45757474
Control of early neurogenesis of the Drosophila brain by the head gap genes tll, otd, ems, and btd.Q46124022
Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA.Q46890244
The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterningQ47069443
NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegansQ47069468
EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegansQ47069521
The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription.Q47070833
Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development.Q47071140
Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processesQ47071704
Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in DrosophilaQ47071965
The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.Q47072307
REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish developmentQ47073728
Molecular cloning of polybromo, a nuclear protein containing multiple domains including five bromodomains, a truncated HMG-box, and two repeats of a novel domainQ48059078
Dentatorubral-pallidoluysian atrophy or Naito-Oyanagi diseaseQ48209189
Expression and distribution of the dentatorubral-pallidoluysian atrophy gene product (atrophin-1/drplap) in neuronal and non-neuronal tissuesQ48795581
Competition for overlapping sites in the regulatory region of the Drosophila gene Krüppel.Q52231848
Spatial control of the gap gene knirps in the Drosophila embryo by posterior morphogen systemQ52443475
The zygotic segmentation mutant tailless alters the blastoderm fate map of the Drosophila embryo.Q52463412
A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wingQ58380305
Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptorQ73386741
Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assemblyQ80407843
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicityQ95721056
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesisQ24673923
Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWIQ27642328
The language of covalent histone modificationsQ27860931
Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymesQ27933003
Structure and function of the Saccharomyces cerevisiae Sir3 BAH domainQ27935710
Role of interactions between the origin recognition complex and SIR1 in transcriptional silencingQ27937028
Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrateQ28144273
Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cellsQ28201192
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tailsQ28216534
Mi-2/NuRD: multiple complexes for many purposesQ28250321
Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)Q28250990
The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in DrosophilaQ28252549
Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathwaysQ28253459
Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphismsQ28260268
Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reactionQ28261560
Regulation of LSD1 histone demethylase activity by its associated factorsQ28270391
Protein aggregation and neurodegenerative diseaseQ28273600
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activitiesQ28286772
A transcriptional co-repressor that interacts with nuclear hormone receptorsQ28289864
Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)Q28306588
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesisQ28505117
Dentatorubral-pallidoluysian atrophy protein is phosphorylated by c-Jun NH2-terminal kinaseQ28581934
Loss of the tailless gene affects forebrain development and emotional behaviorQ28585346
Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retinaQ28586084
Expression and function of orphan nuclear receptor TLX in adult neural stem cellsQ28586702
Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1Q28587617
Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicityQ28593520
The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrainQ28594806
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3Q28609763
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domainsQ28609779
Biological roles and mechanistic actions of co-repressor complexesQ28640957
NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activitiesQ29615750
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in DrosophilaQ29616737
Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear.Q30499440
Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP.Q30849521
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferaseQ33272939
Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryosQ33284704
Polyglutamine neurodegenerative diseases and regulation of transcription: assembling the puzzleQ33343058
Dentatorubral-pallidoluysian atrophy (DRPLA): clinical features and molecular genetics.Q33748372
The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulationQ33856691
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptorsQ33881484
Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.Q33890266
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcriptionQ33916580
Glutamine repeats and neurodegenerationQ33938576
Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosisQ33944948
Histone deacetylase inhibitors reduce polyglutamine toxicityQ33953013
Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localizationQ33961469
The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoterQ33977927
Regulation of SMRT and N-CoR corepressor functionQ34145996
The BAH domain, polybromo and the RSC chromatin remodelling complexQ34258291
Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actionsQ34267857
Emerging roles of MTA family members in human cancersQ34276177
The SANT domain: a unique histone-tail-binding module?Q34308307
Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx.Q34331321
Histone deacetylase inhibitors as new cancer drugsQ34416846
The tailless nuclear receptor acts as a dedicated repressor in the early Drosophila embryoQ34564826
EODJEMOREQ34567156
A role for adult TLX-positive neural stem cells in learning and behaviourQ34743630
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's diseaseQ34763178
Genetic interactions among scribbler, Atrophin and groucho in Drosophila uncover links in transcriptional repressionQ34895744
Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genesQ35209119
Nuclear receptor recruitment of histone-modifying enzymes to target gene promotersQ35802810
Do protein motifs read the histone code?Q36017986
Histone deacetylase inhibitors: gathering paceQ36509550
MTA family of coregulators in nuclear receptor biology and pathologyQ37050256
A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylationQ38353000
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.Q39576827
P921main subjectintracellular receptorQ117980
transcription factorQ407384
regulation of gene expressionQ411391
transport proteinQ2111029
DNA-binding proteinQ2252764
nerve tissue proteinQ6996861
arthropod proteinsQ75832127
P304page(s)e009
P577publication date2008-10-31
P1433published inNuclear Receptor SignalingQ15766610
P1476titleAtrophin proteins: an overview of a new class of nuclear receptor corepressors
P478volume6

Reverse relations

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