Defective MHC class II presentation by dendritic cells limits CD4 T cell help for antitumor CD8 T cell responses

scientific article published on July 2008

Defective MHC class II presentation by dendritic cells limits CD4 T cell help for antitumor CD8 T cell responses is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.181.1.155
P932PMC publication ID2587216
P698PubMed publication ID18566380
P5875ResearchGate publication ID5288969

P2093author name stringMichael Y Gerner
Matthew F Mescher
Kerry A Casey
P2860cites workCD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.Q24540429
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activationQ24677534
Tumor-specific CD4+ T cells have a major "post-licensing" role in CTL mediated anti-tumor immunityQ28138211
Cancer despite immunosurveillance: immunoselection and immunosubversionQ28263865
Differential antigen processing by dendritic cell subsets in vivoQ29615177
Immunosuppressive networks in the tumour environment and their therapeutic relevanceQ29619244
Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis.Q33756652
Initial T cell frequency dictates memory CD8+ T cell lineage commitmentQ33768584
Autophagy promotes MHC class II presentation of peptides from intracellular source proteinsQ33841180
Cell biology of antigen processing in vitro and in vivoQ33985828
Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell MemoryQ34190038
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection.Q34339494
Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunityQ34357808
Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection.Q36008100
In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumorQ36229738
CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivoQ36367705
Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector functionQ36370978
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.Q36371632
Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturationQ36376648
Reciprocal changes in tumor antigenicity and antigen-specific T cell function during tumor progressionQ36399807
Dendritic cells in a mature age.Q36475977
Signals required for programming effector and memory development by CD8+ T cellsQ36528952
Inflaming the CD8+ T cell response.Q36543883
Cellular protein is the source of cross-priming antigen in vivoQ36853548
Signal 3 availability limits the CD8 T cell response to a solid tumorQ40130393
Reversing tumor immune suppression with intratumoral IL-12: activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8+ T effectors.Q40212541
A spontaneously arising pancreatic tumor does not promote the differentiation of naive CD8+ T lymphocytes into effector CTL.Q40553918
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytesQ40669542
Administration of interleukin-12 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines in mouse hepatocellular carcinomaQ40774007
Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumorsQ42029476
CD4+ T cells can protect APC from CTL-mediated eliminationQ44678363
Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against LeishmaniaQ44920559
The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the folliclesQ48914128
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction.Q51983318
Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo.Q52003804
Augmented induction of CD8+ cytotoxic T-cell response and antitumour resistance by T helper type 1-inducing peptide.Q53640046
CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanismQ56906680
Cutting Edge: Precursor Frequency Affects the Helper Dependence of Cytotoxic T CellsQ57227884
Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In VivoQ57227930
Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8- Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic CellsQ57227937
Activation of Dendritic Cells That Cross-Present Tumor-Derived Antigen Licenses CD8+ CTL to Cause Tumor EradicationQ58234979
Cytokine depot formulations as adjuvants for tumor vaccines. I. Liposome-encapsulated IL-2 as a depot formulationQ73202999
Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactionsQ73592527
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunityQ73691187
Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsetsQ73785333
Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progressionQ74330354
Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stageQ77787494
Dendritic cells cross-dressed with peptide MHC class I complexes prime CD8+ T cellsQ79287424
Tolerization of tumor-specific T cells despite efficient initial priming in a primary murine model of prostate cancerQ79609573
IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotypeQ80427899
Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptorsQ80444910
Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiationQ81621807
CD4 T cell-dependent conditioning of dendritic cells to produce IL-12 results in CD8-mediated graft rejection and avoidance of toleranceQ81767220
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)155-164
P577publication date2008-07-01
P1433published inJournal of ImmunologyQ3521441
P1476titleDefective MHC class II presentation by dendritic cells limits CD4 T cell help for antitumor CD8 T cell responses
P478volume181

Reverse relations

cites work (P2860)
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