Molecular mechanisms of schizophrenia

scientific article published on January 2007

Molecular mechanisms of schizophrenia is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1159/000110430
P698PubMed publication ID17982252
P5875ResearchGate publication ID5864921

P50authorUndine LangQ5394305
P2093author name stringDaniel J Muller
Nathalie Strutz-Seebohm
Jurgen Gallinat
Imke Puls
P2860cites workGlutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sampleQ46982053
Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrainQ47378030
Association study of -1727 A/T, -50 C/T and (CAA)n repeat GSK-3beta gene polymorphisms with schizophreniaQ47390678
Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophreniaQ48411170
Low GSK-3 activity in frontal cortex of schizophrenic patientsQ48752142
Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology.Q51953367
Schizotypal dimensions: An intermediate phenotype associated with the COMT high activity alleleQ57698054
Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophreniaQ24293245
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophreniaQ24308818
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: SchizophreniaQ24532517
Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sampleQ24540539
Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophreniaQ24612644
Prenatal infection as a risk factor for schizophreniaQ24644310
The regulator of G protein signaling familyQ28145604
Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophreniaQ28239401
Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophreniaQ28283245
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophreniaQ28568230
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex developmentQ28582746
A polygenic theory of schizophreniaQ28972276
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophreniaQ29614929
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergenceQ29618819
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responsesQ29618915
The neuropathology of schizophrenia. A critical review of the data and their interpretationQ30573678
Association of the DTNBP1 locus with schizophrenia in a U.S. populationQ33910454
Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from BulgariaQ33977974
Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosologyQ33991750
Novel neurotransmitters and their neuropsychiatric relevanceQ34073604
Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p.Q34137538
The molecular genetics of schizophrenia: new findings promise new insightsQ35569496
Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disordersQ36499391
The C/C genotype of the C957T polymorphism of the dopamine D2 receptor is associated with schizophreniaQ38333775
Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietinQ38403090
Lifetime prevalence, demographic risk factors, and diagnostic validity of nonaffective psychosis as assessed in a US community sample. The National Comorbidity SurveyQ39435279
Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processingQ42167781
A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorderQ42675472
Polymorphisms of dopamine receptors and tardive dyskinesia among Chinese patients with schizophreniaQ44259395
The influence of typical and atypical neuroleptic drugs in the production of interleukin-2 and interferon-gamma in vitroQ44302488
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.Q46022290
Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memoryQ46113483
Failure to confirm association between RGS4 haplotypes and schizophrenia in CaucasiansQ46355088
Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophreniaQ46418599
Dopamine D3 receptors as a novel target for improving the treatment of schizophreniaQ46422863
Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophreniaQ46775363
Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brainQ46780422
P433issue6
P921main subjectschizophreniaQ41112
P304page(s)687-702
P577publication date2007-01-01
P1433published inCellular Physiology and BiochemistryQ2229420
P1476titleMolecular mechanisms of schizophrenia
P478volume20

Reverse relations

cites work (P2860)
Q3439303722q11 deletion syndrome: a review of the neuropsychiatric features and their neurobiological basis
Q47763251A Protocol for Producing the Maternal Low-Protein Rat Model: A Tool for Preclinical Proteomic Studies
Q34345562A common neuronal response to alphaherpesvirus infection
Q33531348A novel microRNA and transcription factor mediated regulatory network in schizophrenia
Q42437288A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels
Q35760215Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia
Q39928385Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
Q30409979Altered serine/threonine kinase activity in schizophrenia
Q28591808Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system
Q50309747An in Silico, Biomarker-Based Method for the Evaluation of Virtual Neuropsychiatric Drug Effects
Q30386608Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
Q42231418Association between Interleukin 31 Receptor A Gene Polymorphism and Schizophrenia in Korean Population
Q88022657Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population
Q50655624Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and first-episode patients with schizophrenia in a Chinese Han population.
Q48126921Association between two single nucleotide polymorphisms at corresponding microRNA and schizophrenia in a Chinese population.
Q50853508Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population.
Q45363282Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk
Q34078251Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder
Q49126111Association study of GRIK1 gene polymorphisms in schizophrenia: case-control and family-based studies
Q46118805Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population
Q48313856Associations between use of cocaine, amphetamines, or psychedelics and psychotic symptoms in a community sample
Q37069020Biomarkers in Psychiatry - A Critique
Q92580016Brain-Derived Neurotropic Factor Serum Level and Severity Symptom of Bataknese Male Patients with Schizophrenia in North Sumatera, Indonesia
Q35847085Brain-derived neurotrophic factor and neuropsychiatric disorders
Q43928105Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population.
Q30090165Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4.
Q44960454Clozapine and N-Methyl-d-Aspartate have positive modulatory actions on their respective discriminative stimulus properties in C57BL/6 mice
Q90415757Cognitive Enhancing Effect of High-Frequency Neuronavigated rTMS in Chronic Schizophrenia Patients With Predominant Negative Symptoms: A Double-Blind Controlled 32-Week Follow-up Study
Q38124448Comorbid substance use disorder in schizophrenia: a selective overview of neurobiological and cognitive underpinnings
Q33420372Comparison of gene expression profile in embryonic mesencephalon and neuronal primary cultures
Q47679011Corticostriatal circuit defects in Hoxb8 mutant mice
Q21129280Cotinine: Beyond that Expected, More than a Biomarker of Tobacco Consumption
Q47788549Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells
Q33374181Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia
Q48572492Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1.
Q92732345Downregulated AKT-mTOR signaling pathway proteins in dorsolateral prefrontal cortex in Schizophrenia
Q24316880Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment
Q27333743Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.
Q38672722Employing proteomics to unravel the molecular effects of antipsychotics and their role in schizophrenia
Q39315740Expression and methylation of BDNF in the human brain in schizophrenia
Q38508234Gene- and evidence-based candidate gene selection for schizophrenia and gene feature analysis
Q47684050Genetic and Functional Analysis of GRIN2A in Tumor Samples.
Q33560765Genetic and brain structure anomalies in autism spectrum disorders. Towards an understanding of the aetiopathogenesis?
Q46397571Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population
Q33729022Genetics of schizophrenia from a clinicial perspective.
Q33928389Genome-wide association identifies candidate genes that influence the human electroencephalogram
Q24655879Genome-wide association study of anthropometric traits in Korcula Island, Croatia
Q37473779Group II metabotropic glutamate receptors and schizophrenia
Q35149520Heat shock alters the expression of schizophrenia and autism candidate genes in an induced pluripotent stem cell model of the human telencephalon
Q24624921Hematopoietic origin of pathological grooming in Hoxb8 mutant mice
Q37138150Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder
Q51351780Homodimerization enhances both sensitivity and dynamic range of the ligand-binding domain of type 1 metabotropic glutamate receptor.
Q47555364Identifying and exploiting trait-relevant tissues with multiple functional annotations in genome-wide association studies
Q39144681Immersion in altered experience: An investigation of the relationship between absorption and psychopathology
Q33678807Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study
Q30457731Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing
Q34907600Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4.
Q43063737Lack of association between MAGEL2 and schizophrenia and mood disorders in the Japanese population
Q38989183MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets
Q35598966MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia
Q37810163Metabonomic studies of schizophrenia and psychotropic medications: focus on alterations in CNS energy homeostasis
Q37368965MicroRNAs in mental health: from biological underpinnings to potential therapies
Q59697660Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia
Q34137363Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
Q36170150Molecular pathways: dysregulated glutamatergic signaling pathways in cancer
Q26853035Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders
Q33749231NMDA Receptor Hypofunction Induces Dysfunctions of Energy Metabolism And Semaphorin Signaling in Rats: A Synaptic Proteome Study
Q37309811Neuregulin 1-erbB4 pathway in schizophrenia: From genes to an interactome
Q28285114Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway
Q35262436Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway
Q42114745Noise as a mechanism of anomalous face processing among persons with Schizophrenia
Q39818618PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3.
Q35150392Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repression
Q36595706Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability
Q43962534Partial support for ZNF804A genotype-dependent alterations in prefrontal connectivity
Q55000492Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia.
Q48334300Proteomic analysis of the maternal protein restriction rat model for schizophrenia: identification of translational changes in hormonal signaling pathways and glutamate neurotransmission
Q28284253Psychiatric genetics: progress amid controversy
Q24608775Rare structural variation of synapse and neurotransmission genes in autism
Q37800115Role of immune molecules in the establishment and plasticity of glutamatergic synapses
Q37633791Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action
Q37251394SNAP-25 in neuropsychiatric disorders
Q37862242Schizophrenia as a disorder of too little dopamine: implications for symptoms and treatment
Q24317440Significance of SGK1 in the regulation of neuronal function
Q37272524Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.
Q34051230Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation
Q42156149Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia
Q50217150Sub-chronic Antipsychotic Drug Administration Reverses the Expression of Neuregulin 1 and ErbB4 in a Cultured MK801-Induced Mouse Primary Hippocampal Neuron or a Neurodevelopmental Schizophrenia Model
Q50440080Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61.
Q36492240Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation
Q38770356Targeting Retinoid Receptors to Treat Schizophrenia: Rationale and Progress to Date.
Q42749859The dopamine and cAMP regulated phosphoprotein, 32 kDa (DARPP-32) signaling pathway: a novel therapeutic target in traumatic brain injury
Q37800023The dual role of the extracellular matrix in synaptic plasticity and homeostasis
Q89727376The ubiquitin proteasome system and schizophrenia
Q56768394Toxoplasmosis
Q38168821Transcription factor and microRNA co-regulatory loops: important regulatory motifs in biological processes and diseases
Q89421779Two distinct ontogenies confer heterogeneity to mouse brain microglia
Q33933939Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study
Q33707718Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder
Q47073898Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling
Q39038756mRNA Expression and DNA Methylation Analysis of Serotonin Receptor 2A (HTR2A) in the Human Schizophrenic Brain

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