mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM.

scientific article published on 13 April 2016

mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-15-2959
P932PMC publication ID4911293
P698PubMed publication ID27197168

P2093author name stringDevanand Sarkar
Luni Emdad
Paul B Fisher
Praveen Bhoopathi
Swadesh K Das
Xue-Ning Shen
Anjan K Pradhan
Nathaniel Lee
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A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levelsQ34701049
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Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell deathQ36325171
Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancerQ36387940
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Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatinQ37261069
Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24.Q37411957
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Cambogin Induces Caspase-Independent Apoptosis through the ROS/JNK Pathway and Epigenetic Regulation in Breast Cancer Cells.Q38874622
Adenovirus arming human IL-24 inhibits neuroblastoma cell proliferation in vitro and xenograft tumor growth in vivoQ39162230
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.Q39280123
Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cellsQ39740442
Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cellsQ40393341
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.Q40578148
Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.Q40606858
Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidantsQ40972934
Resistance to chemotherapy mediated by TrkB in neuroblastomas.Q44220743
Apoptosis-inducing factor (AIF): caspase-independent after all.Q47961272
Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activityQ48090258
Improved survival in neuroblastoma using multimodality therapyQ70516406
Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regressionQ77733241
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectcell deathQ2383867
neuroblastomaQ938205
P304page(s)3572-3582
P577publication date2016-04-13
P1433published inCancer ResearchQ326097
P1476titlemda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM.
P478volume76

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cites work (P2860)
Q47560447Cancer Terminator Viruses (CTV): A Better Solution for Viral-Based Therapy of Cancer.
Q91755726Effects of melanoma differentiation associated gene-7 (MDA-7/IL-24) on apoptosis of liver cancer cells via regulating the expression of B-cell lymphoma-2
Q64374902MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF
Q93135528Mechanism of internalization of MDA-7/IL-24 protein and its cognate receptors following ligand-receptor docking
Q89519701Mesenchymal stem cells derived from iPSCs expressing interleukin-24 inhibit the growth of melanoma in the tumor-bearing mouse model
Q64072222Murine astrocytes produce IL-24 and are susceptible to the immunosuppressive effects of this cytokine
Q50186335New Insights Into Beclin-1: Evolution and Pan-Malignancy Inhibitor Activity
Q89206404Recombinant MDA-7/IL24 Suppresses Prostate Cancer Bone Metastasis through Downregulation of the Akt/Mcl-1 Pathway
Q92578211Regulation of neuroblastoma migration, invasion, and in vivo metastasis by genetic and pharmacological manipulation of MDA-9/Syntenin
Q54254089Role of MDA-7/IL-24 a Multifunction Protein in Human Diseases.
Q59806800The Interleukin-10 Family of Cytokines and Their Role in the CNS
Q41190055miR-203a-3p.1 targets IL-24 to modulate hepatocellular carcinoma cell growth and metastasis

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