Autophagy regulates selective HMGB1 release in tumor cells that are destined to die.

scientific article published on 10 October 2008

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/CDD.2008.143
P932PMC publication ID2605182
P698PubMed publication ID18846108
P5875ResearchGate publication ID23310394

P50authorArthur E. FrankelQ62695282
P2093author name stringK Hansen
A Thorburn
J Thorburn
H Horita
J Redzic
P2860cites workp62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagyQ24312147
Inhibition of macroautophagy triggers apoptosisQ24338482
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Release of chromatin protein HMGB1 by necrotic cells triggers inflammationQ28131815
Growth factor regulation of autophagy and cell survival in the absence of apoptosisQ28588809
Autophagy: process and functionQ29547296
How to interpret LC3 immunoblottingQ29614175
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3Q29614176
Autophagy in cell death: an innocent convict?Q29617604
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesisQ29617725
Self-eating and self-killing: crosstalk between autophagy and apoptosisQ29617748
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapyQ29619961
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8Q29620200
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genesQ29620366
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphomaQ29622918
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretionQ33193752
Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD.Q34324018
Another way to die: autophagic programmed cell deathQ34462605
Induction of apoptosis by tumor cell-targeted toxinsQ35636355
The role of autophagy in cancer development and response to therapy.Q36251939
Autophagy in cancer: good, bad, or both?Q36612549
The CASBAH: a searchable database of caspase substratesQ36726238
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapyQ36990578
Apoptosis and autophagy: regulatory connections between two supposedly different processesQ36996255
The roles of therapy-induced autophagy and necrosis in cancer treatmentQ37038235
Immunological aspects of cancer chemotherapyQ37039588
Role and regulation of prolyl hydroxylase domain proteinsQ37079729
Does autophagy have a license to kill mammalian cells?Q37206999
Autophagy plays a protective role during zVAD-induced necrotic cell death.Q40016128
HMGB1 is an endogenous immune adjuvant released by necrotic cellsQ40104101
The extracellular release of HMGB1 during apoptotic cell deathQ40253423
Elongation factor-2 kinase regulates autophagy in human glioblastoma cellsQ40304166
Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice.Q40465347
A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cellsQ40654233
Growth arrest and autophagy are required for salivary gland cell degradation in DrosophilaQ41913649
Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerizationQ42819738
The immune response against dying tumor cells: avoid disaster, achieve cureQ43681135
Rapamycin pre-treatment protects against apoptosisQ45300160
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.Q45303665
GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.Q50681145
Immunotoxin therapy of cancerQ56454451
P433issue1
P921main subjectautophagyQ288322
P304page(s)175-183
P577publication date2008-10-10
P1433published inCell Death & DifferentiationQ2943974
P1476titleAutophagy regulates selective HMGB1 release in tumor cells that are destined to die.
P478volume16

Reverse relations

cites work (P2860)
Q23757242A comprehensive glossary of autophagy-related molecules and processes (2nd edition)
Q38795278Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy
Q33392660Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms
Q35927584Antigen Cross-Priming of Cell-Associated Proteins is Enhanced by Macroautophagy within the Antigen Donor Cell.
Q35128650Apoptosis, autophagy, necroptosis, and cancer metastasis
Q48387954Autophagy Biomarkers Beclin 1 and p62 are Increased in Cerebrospinal Fluid after Traumatic Brain Injury
Q38202871Autophagy Contributes to the Death/Survival Balance in Cancer PhotoDynamic Therapy.
Q41919600Autophagy Proteins in Phagocyte Endocytosis and Exocytosis
Q37784816Autophagy Shapes Inflammation
Q49388079Autophagy and Disease
Q60912923Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy
Q42571763Autophagy and apoptosis: what is the connection?
Q38588827Autophagy and autophagy-related proteins in the immune system
Q37967998Autophagy and cancer
Q82997243Autophagy and cancer therapy
Q33584607Autophagy and cancer therapy
Q35928336Autophagy and mechanisms of effective immunity
Q37640885Autophagy and metastasis: another double-edged sword
Q38164897Autophagy in inflammation, infection, neurodegeneration and cancer
Q38869705Autophagy proteins in antigen processing for presentation on MHC molecules
Q47301146Autophagy's secret life: secretion instead of degradation
Q28078649Autophagy-Dependent Secretion: Contribution to Tumor Progression
Q37701461Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
Q92508479Autophagy-dependent secretion: mechanism, factors secreted, and disease implications
Q35172545Autophagy-mediated HMGB1 release promotes gastric cancer cell survival via RAGE activation of extracellular signal-regulated kinases 1/2.
Q35146596Autophagy: cancer's friend or foe?
Q33703592Autophagy: cerebral home cooking
Q26994999Cell death and DAMPs in acute pancreatitis
Q47614555Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses.
Q36297374Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation
Q26768480Circulating HMGB1 and RAGE as Clinical Biomarkers in Malignant and Autoimmune Diseases
Q38267715Complexity of danger: the diverse nature of damage-associated molecular patterns.
Q34097823Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption
Q42553556Consensus guidelines for the detection of immunogenic cell death
Q38928826DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing.
Q34160434DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown
Q38079689DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death
Q30499197DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity
Q38784860Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy
Q28087485Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme
Q27014829Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials
Q36469716Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells
Q39556431Distinct cellular responses induced by saporin and a transferrin-saporin conjugate in two different human glioblastoma cell lines
Q34770544EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages
Q37262805EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins
Q38032609Eat-me: autophagy, phagocytosis, and reactive oxygen species signaling
Q58861244Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock
Q35527165Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design.
Q28077408Enhanced Therapeutic Efficacy in Cancer Patients by Short-term Fasting: The Autophagy Connection
Q33701939GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death
Q45072959HDAC inhibitors enhance the immunotherapy response of melanoma cells
Q34622835HMGB1 in health and disease
Q28243671HMGB1 loves company
Q34154797HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
Q55422081Hemidesmus indicus induces immunogenic death in human colorectal cancer cells.
Q35193976High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress
Q34129779High mobility group box 1 (HMGB1) phenotypic role revealed with stress
Q33638306High-mobility group box 1 and cancer
Q28079816Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet
Q33639097Immunogenic and tolerogenic cell death
Q34311701Immunogenic cell death and DAMPs in cancer therapy
Q39178654Immunogenic cell death: can it be exploited in PhotoDynamic Therapy for cancer?
Q38255959Immunogenicity of necrotic cell death.
Q39429511Impact of Autophagy in Oncolytic Adenoviral Therapy for Cancer
Q55073227Impact of Paneth Cell Autophagy on Inflammatory Bowel Disease.
Q35658529Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer
Q38622286Inflammatory Signaling Cascades and Autophagy in Cancer
Q37570542Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease
Q37437339Intralesional rose bengal in melanoma elicits tumor immunity via activation of dendritic cells by the release of high mobility group box 1
Q36562901Life after death: targeting high mobility group box 1 in emergent cancer therapies
Q57498214Linking Autophagy and the Dysregulated NFκB/ SNAIL/YY1/RKIP/PTEN Loop in Cancer: Therapeutic Implications
Q59133970Liposomal Formulations to Modulate the Tumour Microenvironment and Antitumour Immune Response
Q26822491Local tumour ablative therapies: opportunities for maximising immune engagement and activation
Q57269850Mechanism and medical implications of mammalian autophagy
Q92875471Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery
Q38786090Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1.
Q35919064MiR-218 inhibits HMGB1-mediated autophagy in endometrial carcinoma cells during chemotherapy.
Q39490156Modulation of pediatric brain tumor autophagy and chemosensitivity
Q36301061Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
Q84220622Molecular biology of chronic myeloid leukemia
Q33751106Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review
Q27023542Ménage à Trois in stress: DAMPs, redox and autophagy
Q35745292NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response
Q48591203Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance
Q41833885Non-apoptotic routes to defeat cancer
Q38726186Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells
Q37707676Oncolytic Immunotherapy: Dying the Right Way is a Key to Eliciting Potent Antitumor Immunity
Q21245758Oncolytic viruses as therapeutic cancer vaccines
Q27000955Oxidative stress-mediated HMGB1 biology
Q39223354Paradoxical Role of High Mobility Group Box 1 in Glioma: A Suppressor or a Promoter?
Q39381435Perpetual change: autophagy, the endothelium, and response to vascular injury
Q42370084Proinflammatory Effect of High Glucose Concentrations on HMrSV5 Cells via the Autocrine Effect of HMGB1
Q39135022ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death
Q38696036Radiation-induced autophagy: mechanisms and consequences.
Q92676366Radiotherapy activates autophagy to increase CD8+ T cell infiltration by modulating major histocompatibility complex class-I expression in non-small cell lung cancer
Q38560502Redox distress and genetic defects conspire in systemic autoinflammatory diseases
Q100332692Regulation and Function of Autophagy During Ferroptosis
Q39903161Regulation of HMGB1 release by autophagy
Q35669880Resimmune, an anti-CD3ε recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma
Q52629816Role of autophagy in IL-1β export and release from cells.
Q41922999Role of autophagy in oncolytic herpes simplex virus type 1-induced cell death in squamous cell carcinoma cells
Q28246367Rose Bengal acetate photodynamic therapy (RBAc-PDT) induces exposure and release of Damage-Associated Molecular Patterns (DAMPs) in human HeLa cells
Q98564735S100A8 transported by SEC23A inhibits metastatic colonization via autocrine activation of autophagy
Q28086767Secretory autophagy
Q38252589Secretory function of autophagy in innate immune cells
Q33809521Stepwise release of biologically active HMGB1 during HSV-2 infection
Q36747309Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response
Q37858077Targeting autophagy during cancer therapy to improve clinical outcomes
Q89587163The Multifaceted Effects of Autophagy on the Tumor Microenvironment
Q35393206The dynamic nature of autophagy in cancer
Q60924219The progression of HMGB1-induced autophagy in cancer biology
Q26829321The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases
Q38898214Transplantation and Damage-Associated Molecular Patterns (DAMPs).
Q37222171Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway
Q38622540[pemetrexed + sildenafil], via autophagy-dependent HDAC down-regulation, enhances the immunotherapy response of NSCLC cells
Q37475020miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma

Search more.