A new role for HIV nucleocapsid protein in modulating the specificity of plus strand priming

scientific article published on 15 July 2008

A new role for HIV nucleocapsid protein in modulating the specificity of plus strand priming is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VIROL.2008.06.002
P932PMC publication ID2607142
P698PubMed publication ID18632127
P5875ResearchGate publication ID51406719

P2093author name stringJeffrey J DeStefano
Deena T Jacob
P2860cites workCrystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNAQ24545723
Selection of primer-template sequences that bind human immunodeficiency virus reverse transcriptase with high affinityQ25257467
NMR structure of stem-loop SL2 of the HIV-1 psi RNA packaging signal reveals a novel A-U-A base-triple platformQ27624968
A mechanism for plus-strand transfer enhancement by the HIV-1 nucleocapsid protein during reverse transcriptionQ27625600
NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognitionQ27625936
Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition elementQ27748786
Control of initiation of viral plus strand DNA synthesis by HIV reverse transcriptaseQ38339110
Effect of human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein on HIV-1 reverse transcriptase activity in vitroQ38362867
Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replicationQ39578721
Roles of the human immunodeficiency virus type 1 nucleocapsid protein in annealing and initiation versus elongation in reverse transcription of viral negative-strand strong-stop DNAQ39582290
Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptaseQ40060658
The orientation of binding of human immunodeficiency virus reverse transcriptase on nucleic acid hybridsQ40396110
Quantitative analysis of RNA cleavage during RNAdirected DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptasesQ40401252
Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycleQ40405392
Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptaseQ40410001
Transactivation of the minus-strand DNA transfer by nucleocapsid protein during reverse transcription of the retroviral genome.Q40790993
Target specificity of human immunodeficiency virus type 1 NCp7 requires an intact conformation of its CCHC N-terminal zinc finger.Q40886902
Point mutations in conserved amino acid residues within the C-terminal domain of HIV-1 reverse transcriptase specifically repress RNase H functionQ42078934
Role of distal zinc finger of nucleocapsid protein in genomic RNA dimerization of human immunodeficiency virus type 1; no role for the palindrome crowning the R-U5 hairpinQ42643768
Substrate requirements for secondary cleavage by HIV-1 reverse transcriptase RNase H.Q43414224
Interaction of human immunodeficiency virus nucleocapsid protein with a structure mimicking a replication intermediate. Effects on stability, reverse transcriptase binding, and strand transferQ43638285
Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptaseQ43903247
Conformational changes between human immunodeficiency virus type 1 nucleocapsid protein NCp7 and its precursor NCp15 as detected by anti-NCp7 monoclonal antibodiesQ44187086
Ordered aggregation of ribonucleic acids by the human immunodeficiency virus type 1 nucleocapsid protein.Q44821597
Role of the zinc fingers of HIV-1 nucleocapsid protein in maturation of genomic RNA.Q44853687
Properties and growth mechanism of the ordered aggregation of a model RNA by the HIV-1 nucleocapsid protein: an electron microscopy investigationQ44987232
The single-finger nucleocapsid protein of moloney murine leukemia virus binds and destabilizes the TAR sequences of HIV-1 but does not promote efficiently their annealingQ45399144
Differing roles of the N- and C-terminal zinc fingers in human immunodeficiency virus nucleocapsid protein-enhanced nucleic acid annealingQ45723126
RNA degradation and primer selection by Moloney murine leukemia virus reverse transcriptase contribute to the accuracy of plus strand initiationQ45742892
Human immunodeficiency virus nucleocapsid protein accelerates strand transfer of the terminally redundant sequences involved in reverse transcriptionQ45781894
Influence of human immunodeficiency virus nucleocapsid protein on synthesis and strand transfer by the reverse transcriptase in vitroQ45789166
Human immunodeficiency virus nucleocapsid protein stimulates strand transfer from internal regions of heteropolymeric RNA templatesQ45790185
Recombinant human immunodeficiency virus type 1 nucleocapsid (NCp7) protein unwinds tRNAQ45867512
MELTING, computing the melting temperature of nucleic acid duplex.Q52049899
Mechanistic analysis of pause site-dependent and -independent recombinogenic strand transfer from structurally diverse regions of the HIV genome.Q53635184
HIV nucleocapsid protein. Expression in Escherichia coli, purification, and characterizationQ72865453
Wild-type and mutant HIV type 1 nucleocapsid proteins increase the proportion of long cDNA transcripts by viral reverse transcriptaseQ73307812
Steps of the acceptor invasion mechanism for HIV-1 minus strand strong stop transferQ73703008
Physical mapping of HIV reverse transcriptase to the 5' end of RNA primersQ74147662
Kinetic analysis of the effect of HIV nucleocapsid protein (NCp) on internal strand transfer reactionsQ77357856
Involvement of HIV-I nucleocapsid protein in the recruitment of reverse transcriptase into nucleoprotein complexes formed in vitroQ77631083
A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replicationQ28646734
Human immunodeficiency virus type 1 preintegration complexes containing discontinuous plus strands are competent to integrate in vitroQ28646839
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNAQ29620616
Coupled integration of human immunodeficiency virus type 1 cDNA ends by purified integrase in vitro: stimulation by the viral nucleocapsid proteinQ30453495
The role of Pr55(gag) in the annealing of tRNA3Lys to human immunodeficiency virus type 1 genomic RNAQ30453508
High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase.Q33197517
Zinc finger structures in the human immunodeficiency virus type 1 nucleocapsid protein facilitate efficient minus- and plus-strand transferQ33604321
Protein-RNA recognitionQ33638761
The human immunodeficiency virus type 1 Gag polyprotein has nucleic acid chaperone activity: possible role in dimerization of genomic RNA and placement of tRNA on the primer binding siteQ33647840
Effect of polypurine tract (PPT) mutations on human immunodeficiency virus type 1 replication: a virus with a completely randomized PPT retains low infectivityQ33788773
Proteolytic processing of the p2/nucleocapsid cleavage site is critical for human immunodeficiency virus type 1 RNA dimer maturation.Q33845445
Specific zinc-finger architecture required for HIV-1 nucleocapsid protein's nucleic acid chaperone functionQ34065314
Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H.Q34333528
Structural and functional properties of the HIV-1 RNA-tRNA(Lys)3 primer complex annealed by the nucleocapsid protein: comparison with the heat-annealed complexQ34364188
Human immunodeficiency virus type 1 nucleocapsid zn(2+) fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA.Q34464770
Subtle alterations of the native zinc finger structures have dramatic effects on the nucleic acid chaperone activity of human immunodeficiency virus type 1 nucleocapsid proteinQ34999333
Synthesis of plus strands of retroviral DNA in cells infected with avian sarcoma virus and mouse mammary tumor virusQ35235206
Unique progressive cleavage mechanism of HIV reverse transcriptase RNase HQ35360809
'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virusQ35796073
Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract.Q35866117
Evidence from CD spectra that d(purine).r(pyrimidine) and r(purine).d(pyrimidine) hybrids are in different structural classesQ35870906
Human immunodeficiency virus type 1 nucleocapsid protein promotes efficient strand transfer and specific viral DNA synthesis by inhibiting TAR-dependent self-priming from minus-strand strong-stop DNA.Q35888060
Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitroQ35890609
Effects of nucleic acid local structure and magnesium ions on minus-strand transfer mediated by the nucleic acid chaperone activity of HIV-1 nucleocapsid proteinQ35891627
Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanismQ36258296
Discontinuous plus-strand DNA synthesis in human immunodeficiency virus type 1-infected cells and in a partially reconstituted cell-free systemQ36548782
Evidence that a central domain of nucleocapsid protein is required for RNA packaging in murine leukemia virusQ36635629
The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalentQ36650013
A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract.Q36688827
Structure/function mapping of amino acids in the N-terminal zinc finger of the human immunodeficiency virus type 1 nucleocapsid protein: residues responsible for nucleic acid helix destabilizing activityQ36791048
In vitro synthesis of long DNA products in reactions with HIV-RT and nucleocapsid proteinQ36804480
HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitroQ37427179
Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptaseQ38288991
Formation of stable and functional HIV-1 nucleoprotein complexes in vitroQ38290544
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectviral nucleocapsidQ4384107
HIVQ15787
P1104number of pages12
P304page(s)385-396
P577publication date2008-07-15
P1433published inVirologyQ7934867
P1476titleA new role for HIV nucleocapsid protein in modulating the specificity of plus strand priming
P478volume378

Reverse relations

cites work (P2860)
Q36553297A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.
Q47552849An Evolutionary/Biochemical Connection Between Promoter- and Primer-Dependent Polymerases Revealed by Selective Evolution of Ligands by Exponential Enrichment (SELEX).
Q38022377Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1.
Q37149739Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein
Q37945202Implications of the nucleocapsid and the microenvironment in retroviral reverse transcription.
Q35705540Nucleocapsid protein annealing of a primer-template enhances (+)-strand DNA synthesis and fidelity by HIV-1 reverse transcriptase
Q34775658Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription
Q38335419Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer.
Q34358865Viral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract.
Q36625767Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5'-terminal genomic RNA fragments: a paradigm for RNA removal reactions in HIV-1 reverse transcription.