Role of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse

scientific article published on 13 May 2016

Role of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/MMR.2016.5264
P932PMC publication ID4918563
P698PubMed publication ID27176043

P2093author name stringCheng Liu
Li Hong
Wen-Jun Guo
Jie Min
Bing-Shu Li
Sha-Sha Hong
De-Bin Wu
Yao-Dan Liu
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Ras GTPase-activating protein binds to Akt and is required for its activationQ28580317
FOXOs, cancer and regulation of apoptosisQ33642512
Akt, FoxO and regulation of apoptosisQ34173519
Dysregulation of protease and protease inhibitors in a mouse model of human pelvic organ prolapseQ34598627
SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem CellsQ35064623
Mechanical regulation of signaling pathways in boneQ36019769
Expression and significance of lysyl oxidase-like 1 and fibulin-5 in the cardinal ligament tissue of patients with pelvic floor dysfunctionQ36682148
Increased mechanical strain imposed on murine lungs during ventilation in vivo depresses airway responsiveness and activation of protein kinase AktQ36924174
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Redox Regulation of the Intrinsic Pathway in Neuronal ApoptosisQ37784826
Epidemiology and prevalence of pelvic organ prolapseQ38101837
Akt-mediated mechanotransduction in murine fibroblasts during hypertrophic scar formationQ39809173
Effects of mechanical stress on cell adhesion: a possible mechanism for morphological changesQ39974391
Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathwayQ40420070
Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring.Q42044464
The role of cellular senescence on the cyclic stretching-mediated activation of MAPK and ALP expression and activity in human periodontal ligament fibroblasts.Q42459455
Involvement of oxidative stress and mitochondrial apoptosis in the pathogenesis of pelvic organ prolapse.Q44745805
The expression of glutathione peroxidase-1 and the anabolism of collagen regulation pathway transforming growth factor-beta1-connective tissue growth factor in women with uterine prolapse and the clinic significanceQ44880653
Expression of matrix metalloproteinase-1 in round ligament and uterosacral ligament tissue from women with pelvic organ prolapseQ45768242
Oxidative damage to human parametrial ligament fibroblasts induced by mechanical stressQ46690609
Nonobstetric risk factors for symptomatic pelvic organ prolapse.Q51643112
PI3K-AKT-FoxO axis in cancer and aging.Q54559626
Pelvic organ prolapseQ55934704
Retrospective analysis of 711 patients operated on for pelvic relaxation in 1983-1989Q72655906
Mechanical strain delivers anti-apoptotic and proliferative signals to gingival fibroblastsQ80375464
Mechanical loading activates β-catenin signaling in periodontal ligament cellsQ83383392
A new FOXO pathway required for leukemogenesisQ84872803
Prevalence and risk factors for pelvic organ prolapse 20 years after childbirth: a national cohort study in singleton primiparae after vaginal or caesarean deliveryQ85344556
P433issue1
P304page(s)243-253
P577publication date2016-05-13
P1433published inMolecular Medicine ReportsQ26842180
P1476titleRole of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse
P478volume14

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cites work (P2860)
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Q93090350Genome‑wide DNA methylation analysis of uterosacral ligaments in women with pelvic organ prolapse
Q47102873Mechanism of Mechanical Trauma-Induced Extracellular Matrix Remodeling of Fibroblasts in Association with Nrf2/ARE Signaling Suppression Mediating TGF-β1/Smad3 Signaling Inhibition.
Q38705923Role of transforming growth factor β‑1 in the pathogenesis of pelvic organ prolapse: A potential therapeutic target
Q98158668β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells