Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders

scientific article published on 04 May 2016

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1194/JLR.M064709
P932PMC publication ID4918844
P698PubMed publication ID27146480

P50authorJohn ChiangQ68164337
Feng LiQ85652273
P2093author name stringShannon Boehme
Jessica M Ferrell
P2860cites workFXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascadeQ45183082
The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.Q50999029
Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin.Q51482499
Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.Q52519814
Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbitsQ73462744
27-hydroxycholesterol: production rates in normal human subjectsQ77959231
A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitisQ82824308
Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesisQ93919581
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptorsQ24290397
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expressionQ24336351
Integrated physiology and systems biology of PPARαQ24564130
The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic controlQ24629879
Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formationQ24652848
Bile acids: regulation of synthesisQ24658139
Bile acid signaling in metabolic disease and drug therapyQ28244875
Detection of the steroidogenic acute regulatory protein, StAR, in human liver cellsQ28247809
Farnesoid X receptor is essential for normal glucose homeostasisQ28591952
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic miceQ34304725
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistQ34326973
Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.Q34451281
Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient miceQ34980363
Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasisQ35181443
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesityQ35693984
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery.Q35703158
Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids.Q36060415
Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acidQ36114905
beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytesQ36977082
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in miceQ36979341
PCSK9: a convertase that coordinates LDL catabolismQ37173223
Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acidsQ37333477
A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitusQ37507016
Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilizationQ38204530
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinaseQ39981968
Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasisQ42103139
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in miceQ42110387
Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient miceQ44317085
Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouseQ44441744
Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutionsQ45041992
Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat.Q45108263
P433issue7
P304page(s)1144-1154
P577publication date2016-05-04
P1433published inJournal of Lipid ResearchQ6295449
P1476titleCholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders
P478volume57

Reverse relations

cites work (P2860)
Q92435693Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters
Q57119190Animal models to study bile acid metabolism
Q57128767Bile acid metabolism and signaling in liver disease and therapy
Q47645986Bile acid metabolism in liver pathobiology
Q94475532Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease
Q90731281Bile acids in glucose metabolism and insulin signalling - mechanisms and research needs
Q41649308Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis
Q92255685Comparative Effects and Mechanisms of Chitosan and Its Derivatives on Hypercholesterolemia in High-Fat Diet-Fed Rats
Q92666284Correlation between 12α-hydroxylated bile acids and insulin secretion during glucose tolerance tests in rats fed a high-fat and high-sucrose diet
Q91143156Deficiency of Both Farnesoid X Receptor and Takeda G Protein-Coupled Receptor 5 Exacerbated Liver Fibrosis in Mice
Q55080645Deficiency of cholesterol 7α-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice.
Q90310328Gut microbiota and cardiovascular disease: opportunities and challenges
Q57818789Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression
Q92106425Intestinal Absorption of Bile Acids in Health and Disease
Q57116884Low-density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression
Q58602512Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
Q53705753Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Q47162245Recent advances in understanding bile acid homeostasis.
Q89612196Role of Mineralocorticoid Receptor in Adipogenesis and Obesity in Male Mice
Q33658912SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model
Q38740970Shp deletion prevents hepatic steatosis and when combined with Fxr loss protects against type 2 diabetes
Q89520624The acidic pathway of bile acid synthesis: Not just an alternative pathway☆
Q53690107Unexplained reciprocal regulation of diabetes and lipoproteins.

Search more.