Uncoupling of myocardial beta-adrenergic receptor signaling during coronary artery bypass grafting: the role of GRK2.

scientific article published on October 2008

Uncoupling of myocardial beta-adrenergic receptor signaling during coronary artery bypass grafting: the role of GRK2. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.ATHORACSUR.2008.05.042
P932PMC publication ID2613564
P698PubMed publication ID18805158
P5875ResearchGate publication ID23270924

P2093author name stringShahab A Akhter
Karen M D'Souza
Christian F Bulcao
Prakash K Pandalai
Walter H Merrill
P2860cites workPreservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarctionQ24656335
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Functional consequences of altering myocardial adrenergic receptor signalingQ33938713
Seven-transmembrane-spanning receptors and heart functionQ34503394
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transferQ36637020
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinaseQ38293222
Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.Q38322188
Structure and mechanism of the G protein-coupled receptor kinases.Q40774628
Desensitization of myocardial beta-adrenergic receptors during cardiopulmonary bypass. Evidence for early uncoupling and late downregulationQ41131503
Pharmacological criteria for ventricular assist device insertion following postcardiotomy shock: experience with the Abiomed BVS systemQ42629041
Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac functionQ45861641
A highly sensitive adenylate cyclase assayQ47871494
Effects of pulsatile perfusion on plasma catecholamine levels and hemodynamics during and after cardiac operations with cardiopulmonary bypass.Q51742353
Hemodynamic and adrenergic responses to anesthesia and operation for myocardial revascularization.Q51875126
The deleterious effects of myocardial catecholamines on cellular electrophysiology and arrhythmias during ischaemia and reperfusion.Q53906666
Anoxia-induced Release of Noradrenaline from the Isolated Perfused HeartQ59076827
Effect of locally released catecholamines on lipolysis and injury of the hypoxic isolated rabbit heartQ71199544
Neuronal and adrenomedullary catecholamine release in response to cardiopulmonary bypass in manQ72108887
Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heartQ72737102
Uncoupling of human cardiac beta-adrenoceptors during cardiopulmonary bypass with cardioplegic cardiac arrestQ72946078
Urine and plasma catecholamine and cortisol concentrations after myocardial revascularization. Modulation by continuous sedation. Multicenter Study of Perioperative Ischemia (McSPI) Research Group, and the Ischemia Research and Education FoundationQ73228487
Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization GroupQ77319395
In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and functionQ78108722
Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failureQ80962713
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcoronary artery bypass surgeryQ186020
P1104number of pages6
P304page(s)1189-1194
P577publication date2008-10-01
P1433published inThe Annals of Thoracic SurgeryQ1939819
P1476titleUncoupling of myocardial beta-adrenergic receptor signaling during coronary artery bypass grafting: the role of GRK2.
P478volume86

Reverse relations

cites work (P2860)
Q37907329A role for GRK2 in myocardial ischemic injury: indicators of a potential future therapy and diagnostic
Q36882325AAV6-βARKct gene delivery mediated by molecular cardiac surgery with recirculating delivery (MCARD) in sheep results in robust gene expression and increased adrenergic reserve
Q36963181MCARD-mediated gene transfer of GRK2 inhibitor in ovine model of acute myocardial infarction
Q40350188Myocardial function after polarizing versus depolarizing cardiac arrest with blood cardioplegia in a porcine model of cardiopulmonary bypass
Q50698605Off-pump surgery: is it beneficial in patients with left ventricular dysfunction?