HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924.

scientific article published on 02 September 2008

HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1535-7163.MCT-08-0493
P932PMC publication ID2614316
P698PubMed publication ID18765823

P50authorCharles ErlichmanQ107069384
P2093author name stringPaul Haluska
Joan M Carboni
Marco M Gottardis
Xiaonan Hou
Chunrong Yu
Tai W Wong
Ricardo M Attar
Malvika Sagar
Cynthia TenEyck
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Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling.Q40216149
In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.Q40333087
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cellsQ40344963
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activityQ40379343
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The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathwayQ40521524
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Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cellsQ44262979
Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cellsQ44675816
Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumorsQ46972238
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P433issue9
P921main subjectpreproinsulinQ7240673
P304page(s)2589-2598
P577publication date2008-09-02
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleHER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924.
P478volume7

Reverse relations

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