HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells

scientific article

HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20120724
P932PMC publication ID3722874
P698PubMed publication ID22853430

P2093author name stringAndrei Goga
Lionel Lim
Mark M Moasser
Dhara N Amin
Natalia Sergina
P2860cites workActive-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Q21145847
Regulation of endothelium-derived nitric oxide production by the protein kinase AktQ22010149
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylationQ22010150
EGFR/Met association regulates EGFR TKI resistance in breast cancerQ24338635
Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimeraQ24595150
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3Q24633878
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationQ24678674
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3Q27646596
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinasesQ27652488
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.Q27851483
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomasQ28287906
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteinsQ28507365
The Akt kinase signals directly to endothelial nitric oxide synthaseQ28609847
Epidermal growth factor receptor mutations in lung cancerQ29615474
Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membraneQ30445667
Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblastsQ33651661
ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell linesQ33928631
The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapyQ34325749
The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeuticsQ34349389
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesisQ34493341
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activityQ34511038
Resiliency and vulnerability in the HER2-HER3 tumorigenic driverQ34551761
ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cellsQ34637108
Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinaseQ34720797
microRNA-205 regulates HER3 in human breast cancerQ34960615
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activityQ35684026
Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitorsQ35779022
Membrane traffic: controlling membrane fusion by modifying NSF.Q35959045
The epidermal growth factor receptor familyQ36236606
Signaling through ERBB receptors: multiple layers of diversity and controlQ36388160
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factorQ36653753
Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.Q38340048
HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapyQ39368710
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor.Q39821682
A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapyQ39960692
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.Q39979475
Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125bQ40207487
The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3.Q40281070
Dominant negative interference of transcription factor AP-2 causes inhibition of ErbB-3 expression and suppresses malignant cell growthQ40748909
Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor proteinQ41120641
SNAREs and NSF in targeted membrane fusionQ41566661
S-nitrosylation of NSF controls membrane trafficking.Q44624356
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficienciesQ45067792
Synergistic effects of foretinib with HER-targeted agents in MET and HER1- or HER2-coactivated tumor cellsQ54391771
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)417-425
P577publication date2012-11-01
P1433published inBiochemical JournalQ864221
P1476titleHER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells
P478volume447

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cites work (P2860)
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Q33772914ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)
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Q35201923HER-3 peptide vaccines/mimics: Combined therapy with IGF-1R, HER-2, and HER-1 peptides induces synergistic antitumor effects against breast and pancreatic cancer cells
Q28551145HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B
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Q38725101HER3 as a Therapeutic Target in Cancer
Q27853067HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models
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Q41036589SNP rs3202538 in 3'UTR region of ErbB3 regulated by miR-204 and miR-211 promote gastric cancer development in Chinese population
Q35890128Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum
Q34036131Targeting HER3 with miR-450b-3p suppresses breast cancer cells proliferation
Q41667670The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation
Q38766447The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
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Q38876630hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.

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