Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections

scientific article published on 09 May 2016

Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1097/QAD.0000000000001147
P932PMC publication ID4925311
P698PubMed publication ID27163705

P50authorMarcus BuggertQ47258443
David F G MaloneQ57430278
Marianne JanssonQ61755906
Annika C KarlssonQ88351834
Susanna M BächleQ117485268
Johan K SandbergQ40143017
P2093author name stringPatrik Medstrand
Markus Moll
Antonio J Biague
Hans Norrgren
Per-Erik Isberg
SWEGUB CORE group
P2860cites workEmerging concepts in the immunopathogenesis of AIDSQ22241984
Microbial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
The transcription factor PLZF directs the effector program of the NKT cell lineageQ24654999
Transcriptional regulation of the NKT cell lineageQ27012749
Inhibition of HIV-1 disease progression by contemporaneous HIV-2 infectionQ28271332
Impaired natural killer cell responses are associated with loss of the highly activated NKG2A(+)CD57(+)CD56(dim) subset in HIV-1 subtype D infection in UgandaQ33654658
Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infectionQ41842825
The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturationQ42212740
Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individualsQ42219856
Activation of NK cells is associated with HIV-1 disease progressionQ42244605
Prevalence and incidence of HIV-1 and HIV-2 before, during and after a civil war in an occupational cohort in Guinea-Bissau, West Africa.Q42624320
T-cell subset alterations in HIV-infected homosexual men: NIAID Multicenter AIDS cohort studyQ43786352
Optimal cellular preservation for high dimensional flow cytometric analysis of multicentre trialsQ43914078
Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-BissauQ44430005
HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127.Q44519131
Direct relationship between virus load and systemic immune activation in HIV-2 infectionQ45247367
Plasma viral load in HIV-1 and HIV-2 singly and dually infected individuals in Guinea-Bissau, West Africa: significantly lower plasma virus set point in HIV-2 infection than in HIV-1 infectionQ45739618
Dominant effector memory characteristics, capacity for dynamic adaptive expansion, and sex bias in the innate Valpha24 NKT cell compartment.Q45980825
Distinct profile of T cell activation in HIV type 2 compared to HIV type 1 infection: differential mechanism for immunoprotection.Q46002704
HIV-1, HIV-2, HTLV-I/II and Treponema pallidum infections: incidence, prevalence, and HIV-2-associated mortality in an occupational cohort in Guinea-BissauQ46934795
Baseline plasma viral load and CD4 cell percentage predict survival in HIV-1- and HIV-2-infected women in a community-based cohort in The GambiaQ46973654
Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activation.Q47439250
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cellsQ47765721
Studies on toll-like receptor stimuli responsiveness in HIV-1 and HIV-2 infectionsQ47988143
Plasma RNA viral load predicts the rate of CD4 T cell decline and death in HIV-2-infected patients in West AfricaQ50659100
CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load.Q52010705
CD56 negative NK cells: origin, function, and role in chronic viral diseaseQ56953283
Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral loadQ58034113
Microbial Translocation Correlates with the Severity of Both HIV‐1 and HIV‐2 InfectionsQ58320032
Successfully treated HIV-infected patients have differential expression of NK cell receptors (NKp46 and NKp30) according to AIDS status at presentationQ61718753
Serum neopterin and beta 2-microglobulin in anti-HIV positive blood donorsQ69889335
Natural killer cell immunodeficiency in HIV disease is manifest by profoundly decreased numbers of CD16+CD56+ cells and expansion of a population of CD16dimCD56- cells with low lytic activityQ71726450
A subset of CD4+ thymocytes selected by MHC class I moleculesQ72671900
Low peripheral blood viral HIV-2 RNA in individuals with high CD4 percentage differentiates HIV-2 from HIV-1 infectionQ77296161
Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infectionQ77522486
Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individualsQ95801301
T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infectionQ33916550
Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African villageQ33919925
Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patientQ34019039
Protection versus pathology in aviremic and high viral load HIV-2 infection-the pivotal role of immune activation and T-cell kineticsQ34034072
Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesisQ34035802
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functionsQ34323476
Selective loss of innate CD4(+) V alpha 24 natural killer T cells in human immunodeficiency virus infectionQ34342894
Immune activation and HIV persistence: implications for curative approaches to HIV infectionQ34351320
Invariant NKT cells: regulation and function during viral infectionQ34390484
Natural killer cell function is well preserved in asymptomatic human immunodeficiency virus type 2 (HIV-2) infection but similar to that of HIV-1 infection when CD4 T-cell counts fall.Q34434825
Changes in Natural Killer cell activation and function during primary HIV-1 InfectionQ34551274
Severe functional impairment and elevated PD-1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infectionQ34604276
HIV-associated chronic immune activationQ34653277
Potent autologous and heterologous neutralizing antibody responses occur in HIV-2 infection across a broad range of infection outcomesQ35665765
Potent intratype neutralizing activity distinguishes human immunodeficiency virus type 2 (HIV-2) from HIV-1Q35665921
T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cellsQ35848548
Robust Gag-specific T cell responses characterize viremia control in HIV-2 infectionQ35970916
Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapyQ36304297
Defective natural immunity: an early manifestation of human immunodeficiency virus infectionQ36365332
CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infectionQ36370230
PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell FunctionQ36482182
Effect of complement on HIV-2 plasma antiviral activity is intratype specific and potentQ36506821
Polyfunctional T cell responses are a hallmark of HIV-2 infectionQ36618086
Frequent intratype neutralization by plasma immunoglobulin a identified in HIV type 2 infection.Q36634790
T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrowQ37630226
Development of PLZF-expressing innate T cellsQ37831694
Control of human viral infections by natural killer cellsQ38072477
T-bet: a bridge between innate and adaptive immunity.Q38151473
Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infectionQ38812394
CD4+ T-lymphocyte counts in HIV infection: are European standards applicable to African patients?Q38875947
CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infectionQ39006369
HIV-2-induced immunosuppression among asymptomatic West African prostitutes: evidence that HIV-2 is pathogenic, but less so than HIV-1Q39348736
Broad and potent neutralizing antibody responses elicited in natural HIV-2 infectionQ39451862
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
P304page(s)1713-1722
P577publication date2016-05-09
P1433published inAIDSQ4651863
P1476titleElevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections
P478volume30

Reverse relations

cites work (P2860)
Q52332737CD1-Restricted T Cells During Persistent Virus Infections: "Sympathy for the Devil".
Q37312729CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection
Q55000980Functional Invariant Natural Killer T Cells Secreting Cytokines Are Associated With Non-Progressive Human Immunodeficiency Virus-1 Infection but Not With Suppressive Anti-Retroviral Treatment.
Q89530689HIV treatment in Guinea-Bissau: room for improvement and time for new treatment options
Q93104023HIV-2 as a model to identify a functional HIV cure
Q90050669High Activation of γδ T Cells and the γδ2pos T-Cell Subset Is Associated With the Onset of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, ANRS 12153 CAPRI NK
Q90822890Immune response to a Tdap booster in vertically HIV-infected adolescents
Q92130709Immunological profiles of HIV-positive recipients of liver transplant
Q36246252Increased Natural Killer Cell Activation in HIV-Infected Immunologic Non-Responders Correlates with CD4+ T Cell Recovery after Antiretroviral Therapy and Viral Suppression.
Q33390790Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion
Q37721215Negative Checkpoint Regulatory Molecule 2B4 (CD244) Upregulation Is Associated with Invariant Natural Killer T Cell Alterations and Human Immunodeficiency Virus Disease Progression

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