Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

scientific article published on 11 June 2013

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.444364
P932PMC publication ID3724646
P698PubMed publication ID23760271

P50authorMichael FrotscherQ1927477
P2093author name stringMichael Schäfer
Joachim Herz
Akos Kulik
Petra May
Hans H Bock
Chikako Nakajima
P2860cites workReeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2Q22010158
Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transductionQ22254170
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptorQ24297663
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutationsQ28185270
The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor proteinQ28198177
Reelin activates SRC family tyrosine kinases in neuronsQ28513455
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expressionQ28566984
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxietyQ29615160
Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brainQ30438850
Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.Q33924453
Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptorQ33982023
Synaptic autoregulation by metalloproteases and γ-secretaseQ35203314
Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neuronsQ35306317
The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptorsQ35318104
Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densitiesQ36201722
The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brainQ37071903
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studiesQ37216064
Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.Q37527495
Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons.Q38306299
The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processingQ39665687
The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptorsQ40005626
Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domainQ40743382
Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.Q41470171
Gamma-secretase limits the inflammatory response through the processing of LRP1Q41557178
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegenerationQ42032902
alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neuronsQ43882501
Distinct localization of GABA(B) receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamusQ43889429
Sustained somatic gene inactivation by viral transfer of Cre recombinase.Q47948186
Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain.Q53926723
Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissuesQ58379792
Regulation of motor neuron dendrite growth by NMDA receptor activationQ72164534
Calpain-mediated degradation of PSD-95 in developing and adult rat brainQ73822644
P4510describes a project that usesImageJQ1659584
P433issue30
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
P304page(s)21909-21923
P577publication date2013-06-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleLow density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes
P478volume288

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cites work (P2860)
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